Familial mediterranean fever causes: Difference between revisions
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==Overview== | ==Overview== | ||
[[Familial Mediterranean fever]] is most often [[Causes|caused]] by a [[mutation]] in the [[MEFV]] [[gene]]. This [[gene]] creates [[proteins]] involved in [[inflammation]]. | [[Familial Mediterranean fever]] is most often [[Causes|caused]] by a [[mutation]] in the [[MEFV]] [[gene]]. This [[gene]] creates [[proteins]] involved in [[inflammation]]. There are also reports of FMF cases in the absence causative gene in the genetic screening. | ||
==Causes== | ==Causes== | ||
*[[Familial mediterranean fever|Familial Mediterranean fever]] is [[Causes|caused]] by a [[mutation]] in the [[MEFV]] [[gene]].<ref name="pmid9288094">{{cite journal |vauthors= |title=A candidate gene for familial Mediterranean fever |journal=Nat. Genet. |volume=17 |issue=1 |pages=25–31 |date=September 1997 |pmid=9288094 |doi=10.1038/ng0997-25 |url=}}</ref> | *[[Familial mediterranean fever|Familial Mediterranean fever]] is [[Causes|caused]] by a [[mutation]] in the [[MEFV]] [[gene]].<ref name="pmid9288094">{{cite journal |vauthors= |title=A candidate gene for familial Mediterranean fever |journal=Nat. Genet. |volume=17 |issue=1 |pages=25–31 |date=September 1997 |pmid=9288094 |doi=10.1038/ng0997-25 |url=}}</ref> | ||
*There are reported cases of FMF in the absence of known genetic mutation in their genetic analysis. These studies explain that, in these cases, either mutation occured in non-coding region or the disese were developped due to unknown causes.<ref name="CekinAkyurek2017">{{cite journal|last1=Cekin|first1=Nilgun|last2=Akyurek|first2=Murat Eser|last3=Pinarbasi|first3=Ergun|last4=Ozen|first4=Filiz|title=MEFV mutations and their relation to major clinical symptoms of Familial Mediterranean Fever|journal=Gene|volume=626|year=2017|pages=9–13|issn=03781119|doi=10.1016/j.gene.2017.05.013}}</ref> | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 19:20, 3 June 2019
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Differentiating Familial Mediterranean Fever from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]
Overview
Familial Mediterranean fever is most often caused by a mutation in the MEFV gene. This gene creates proteins involved in inflammation. There are also reports of FMF cases in the absence causative gene in the genetic screening.
Causes
- Familial Mediterranean fever is caused by a mutation in the MEFV gene.[1]
- There are reported cases of FMF in the absence of known genetic mutation in their genetic analysis. These studies explain that, in these cases, either mutation occured in non-coding region or the disese were developped due to unknown causes.[2]
References
- ↑ "A candidate gene for familial Mediterranean fever". Nat. Genet. 17 (1): 25–31. September 1997. doi:10.1038/ng0997-25. PMID 9288094.
- ↑ Cekin, Nilgun; Akyurek, Murat Eser; Pinarbasi, Ergun; Ozen, Filiz (2017). "MEFV mutations and their relation to major clinical symptoms of Familial Mediterranean Fever". Gene. 626: 9–13. doi:10.1016/j.gene.2017.05.013. ISSN 0378-1119.