Morton's neuroma pathophysiology: Difference between revisions
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*The pathogenesis of neuroma is characterized by neural degeneration with epineural and endoneural vascular hyalinization, and perineural fibrosis<ref name="morton">Neuroma. Radiopedia http://radiopaedia.org/cases/morton-neuroma-2 Accessed on April 21, 2016</ref> | *The pathogenesis of neuroma is characterized by neural degeneration with epineural and endoneural vascular hyalinization, and perineural fibrosis<ref name="morton">Neuroma. Radiopedia http://radiopaedia.org/cases/morton-neuroma-2 Accessed on April 21, 2016</ref> | ||
*Morton neuroma is characterized by being located in the 3rd web-space, between 3rd and 4th [[Metatarsals|metatarsal]] heads,<ref>{{cite book | last = Perry | first = Arie | title = Practical surgical neuropathology : a diagnostic approach | publisher = Churchill Livingstone/Elsevier | location = Philadelphia, PA | year = 2010 | isbn = 978-0443069826 }}</ref> or sometimes in the second or fourth interspaces | *Morton neuroma is characterized by being located in the 3rd web-space, between 3rd and 4th [[Metatarsals|metatarsal]] heads,<ref>{{cite book | last = Perry | first = Arie | title = Practical surgical neuropathology : a diagnostic approach | publisher = Churchill Livingstone/Elsevier | location = Philadelphia, PA | year = 2010 | isbn = 978-0443069826 }}</ref> or sometimes in the second or fourth interspaces | ||
*On gross pathology, characteristic findings of neuroma, include:<ref name="wiki">Neuroma. Wikipedia. https://en.wikipedia.org/wiki/Neuroma Accessed on April 21, 2016</ref><ref name="pmid10597831">{{cite journal |vauthors=Wu J, Chiu DT |title=Painful neuromas: a review of treatment modalities |journal=Ann Plast Surg |volume=43 |issue=6 |pages=661–7 |year=1999 |pmid=10597831 |doi= |url=}}</ref> | |||
**Adherent fibrofatty tissue | |||
**Small, firm, [[oval]], yellowish-white, [[Slow|slowly]] [[Growth|growing]], [[palpable]] [[nodule]] on [[skin]] (no discoloration of [[skin]] on the top of [[nodule]]) | |||
**</=2cm in [[Size consistency|size]] | |||
*On microscopic histopathological analysis, characteristic findings of neuroma, include:<ref name="wiki">Neuroma. Wikipedia. https://en.wikipedia.org/wiki/Neuroma Accessed on April 21, 2016</ref><ref name="pmid10597831">{{cite journal |vauthors=Wu J, Chiu DT |title=Painful neuromas: a review of treatment modalities |journal=Ann Plast Surg |volume=43 |issue=6 |pages=661–7 |year=1999 |pmid=10597831 |doi= |url=}}</ref> | |||
**Extensive fibrosis around and within the nerve | |||
**Digital artery | |||
**[[Thrombosis]] | |||
**Arterial thickening | |||
==References== | ==References== |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]
Overview
Neuroma
Pathogenesis
- The pathogenesis of neuroma is characterized by neural degeneration with epineural and endoneural vascular hyalinization, and perineural fibrosis[1]
- Morton neuroma is characterized by being located in the 3rd web-space, between 3rd and 4th metatarsal heads,[2] or sometimes in the second or fourth interspaces
- On gross pathology, characteristic findings of neuroma, include:[3][4]
- On microscopic histopathological analysis, characteristic findings of neuroma, include:[3][4]
- Extensive fibrosis around and within the nerve
- Digital artery
- Thrombosis
- Arterial thickening
References
- ↑ Neuroma. Radiopedia http://radiopaedia.org/cases/morton-neuroma-2 Accessed on April 21, 2016
- ↑ Perry, Arie (2010). Practical surgical neuropathology : a diagnostic approach. Philadelphia, PA: Churchill Livingstone/Elsevier. ISBN 978-0443069826.
- ↑ 3.0 3.1 Neuroma. Wikipedia. https://en.wikipedia.org/wiki/Neuroma Accessed on April 21, 2016
- ↑ 4.0 4.1 Wu J, Chiu DT (1999). "Painful neuromas: a review of treatment modalities". Ann Plast Surg. 43 (6): 661–7. PMID 10597831.