Morton's neuroma medical therapy: Difference between revisions

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==== Non-conservative medical therapy ====
==== Non-conservative medical therapy ====
* When conservative measures fail, following medical therapy is used for non-surgical treatment of neuroma:
* When conservative measures fail, following medical therapy is used for non-surgical treatment of neuroma:<ref name="morton">Neuroma. Radiopedia http://radiopaedia.org/cases/morton-neuroma-2 Accessed on April 21, 2016</ref>
** [[Tricyclic antidepressant|Tricyclic antidepressants]]
** [[Tricyclic antidepressant|Tricyclic antidepressants]]
** Anticonvulsants (more effective)
** Anticonvulsants (more effective)
** Serotonin-norepinephrine reuptake inhibitors
** Serotonin-norepinephrine reuptake inhibitors
** Ultrasound-guided interdigital injection of following nerve blocking agents via '''dorsal approach''' into the site of tenderness:
** Ultrasound-guided interdigital injection of following nerve blocking agents via '''dorsal approach''' into the site of tenderness:<ref name="pmid30208078">{{cite journal| author=Malessy MJA, de Boer R, Muñoz Romero I, Eekhof JLA, van Zwet EW, Kliot M et al.| title=Predictive value of a diagnostic block in focal nerve injury with neuropathic pain when surgery is considered. | journal=PLoS One | year= 2018 | volume= 13 | issue= 9 | pages= e0203345 | pmid=30208078 | doi=10.1371/journal.pone.0203345 | pmc=6135496 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30208078  }} </ref><ref name="pmid23740337">{{cite journal| author=Climent JM, Mondéjar-Gómez F, Rodríguez-Ruiz C, Díaz-Llopis I, Gómez-Gallego D, Martín-Medina P| title=Treatment of Morton neuroma with botulinum toxin A: a pilot study. | journal=Clin Drug Investig | year= 2013 | volume= 33 | issue= 7 | pages= 497-503 | pmid=23740337 | doi=10.1007/s40261-013-0090-0 | pmc=3691490 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23740337  }} </ref><ref name="pmid23636185">{{cite journal| author=Thomson CE, Beggs I, Martin DJ, McMillan D, Edwards RT, Russell D et al.| title=Methylprednisolone injections for the treatment of Morton neuroma: a patient-blinded randomized trial. | journal=J Bone Joint Surg Am | year= 2013 | volume= 95 | issue= 9 | pages= 790-8, S1 | pmid=23636185 | doi=10.2106/JBJS.I.01780 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23636185  }} </ref><ref name="pmid24553891">{{cite journal| author=Schon L| title=An injection of corticosteroid plus anesthetic was more effective than anesthetic alone for Morton neuroma. | journal=J Bone Joint Surg Am | year= 2014 | volume= 96 | issue= 4 | pages= 334 | pmid=24553891 | doi=10.2106/JBJS.9604.ebo028 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24553891  }} </ref><ref name="pmid23636203">{{cite journal| author=Smith RW| title=Steroid injection for Morton neuroma - data-based justification. | journal=J Bone Joint Surg Am | year= 2013 | volume= 95 | issue= 9 | pages= e64 | pmid=23636203 | doi=10.2106/JBJS.M.00172 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23636203  }} </ref><ref name="pmid16733414">{{cite journal| author=Haddad-Zebouni S, Elia D, Aoun N, Okais J, Ghossain M| title=[Regression of Morton neuroma after local injection of steroids]. | journal=J Radiol | year= 2006 | volume= 87 | issue= 5 | pages= 566-8 | pmid=16733414 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16733414  }} </ref><ref name="pmid10340428">{{cite journal| author=Basadonna PT, Rucco V, Gasparini D, Onorato A| title=Plantar fat pad atrophy after corticosteroid injection for an interdigital neuroma: a case report. | journal=Am J Phys Med Rehabil | year= 1999 | volume= 78 | issue= 3 | pages= 283-5 | pmid=10340428 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10340428  }} </ref><ref name="pmid7671475">{{cite journal| author=Reddy PD, Zelicof SB, Ruotolo C, Holder J| title=Interdigital neuroma. Local cutaneous changes after corticosteroid injection. | journal=Clin Orthop Relat Res | year= 1995 | volume=  | issue= 317 | pages= 185-7 | pmid=7671475 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7671475  }} </ref><ref name="pmid27301735">{{cite journal| author=van Vendeloo SN, Ettema HB| title=Skin depigmentation along lymph vessels of the lower leg following local corticosteroid injection for interdigital neuroma. | journal=Foot Ankle Surg | year= 2016 | volume= 22 | issue= 2 | pages= 139-41 | pmid=27301735 | doi=10.1016/j.fas.2016.01.002 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27301735  }} </ref><ref name="pmid29230531">{{cite journal| author=Park YH, Lee JW, Choi GW, Kim HJ| title=Risk factors and the associated cutoff values for failure of corticosteroid injection in treatment of Morton's neuroma. | journal=Int Orthop | year= 2018 | volume= 42 | issue= 2 | pages= 323-329 | pmid=29230531 | doi=10.1007/s00264-017-3707-8 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29230531  }} </ref><ref name="pmid26869493">{{cite journal| author=Mahadevan D, Salmasi M, Whybra N, Nanda A, Gaba S, Mangwani J| title=What factors predict the need for further intervention following corticosteroid injection of Morton's neuroma? | journal=Foot Ankle Surg | year= 2016 | volume= 22 | issue= 1 | pages= 9-11 | pmid=26869493 | doi=10.1016/j.fas.2015.03.007 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26869493  }} </ref><ref name="pmid27037432">{{cite journal| author=Mahadevan D, Attwal M, Bhatt R, Bhatia M| title=Corticosteroid injection for Morton's neuroma with or without ultrasound guidance: a randomised controlled trial. | journal=Bone Joint J | year= 2016 | volume= 98-B | issue= 4 | pages= 498-503 | pmid=27037432 | doi=10.1302/0301-620X.98B4.36880 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27037432  }} </ref><ref name="pmid22585530">{{cite journal| author=Yap LP, McNally E| title=Patient's assessment of discomfort during ultrasound-guided injection of Morton's neuroma: selecting the optimal approach. | journal=J Clin Ultrasound | year= 2012 | volume= 40 | issue= 6 | pages= 330-4 | pmid=22585530 | doi=10.1002/jcu.21926 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22585530  }} </ref><ref name="pmid17515373">{{cite journal| author=Hughes RJ, Ali K, Jones H, Kendall S, Connell DA| title=Treatment of Morton's neuroma with alcohol injection under sonographic guidance: follow-up of 101 cases. | journal=AJR Am J Roentgenol | year= 2007 | volume= 188 | issue= 6 | pages= 1535-9 | pmid=17515373 | doi=10.2214/AJR.06.1463 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17515373  }} </ref><ref name="pmid8722878">{{cite journal| author=Wu KK| title=Morton's interdigital neuroma: a clinical review of its etiology, treatment, and results. | journal=J Foot Ankle Surg | year= 1996 | volume= 35 | issue= 2 | pages= 112-9; discussion 187-8 | pmid=8722878 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8722878  }} </ref><ref name="pmid8620640">{{cite journal| author=Rasmussen MR, Kitaoka HB, Patzer GL| title=Nonoperative treatment of plantar interdigital neuroma with a single corticosteroid injection. | journal=Clin Orthop Relat Res | year= 1996 | volume=  | issue= 326 | pages= 188-93 | pmid=8620640 | doi=10.1097/00003086-199605000-00022 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8620640  }} </ref><ref name="pmid18510900">{{cite journal| author=Markovic M, Crichton K, Read JW, Lam P, Slater HK| title=Effectiveness of ultrasound-guided corticosteroid injection in the treatment of Morton's neuroma. | journal=Foot Ankle Int | year= 2008 | volume= 29 | issue= 5 | pages= 483-7 | pmid=18510900 | doi=10.3113/FAI.2008.0483 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18510900  }} </ref><ref name="pmid18751769">{{cite journal| author=Sofka CM, Adler RS, Ciavarra GA, Pavlov H| title=Ultrasound-guided interdigital neuroma injections: short-term clinical outcomes after a single percutaneous injection--preliminary results. | journal=HSS J | year= 2007 | volume= 3 | issue= 1 | pages= 44-9 | pmid=18751769 | doi=10.1007/s11420-006-9029-9 | pmc=2504098 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18751769  }} </ref><ref name="pmid17515235">{{cite journal| author=Hassouna H, Singh D, Taylor H, Johnson S| title=Ultrasound guided steroid injection in the treatment of interdigital neuralgia. | journal=Acta Orthop Belg | year= 2007 | volume= 73 | issue= 2 | pages= 224-9 | pmid=17515235 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17515235  }} </ref>
*** Steroid
*** Steroid
*** [[Local anaesthetic]]
*** [[Local anaesthetic]]

Revision as of 01:09, 3 June 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]Faizan Sheraz, M.D. [3]

Overview

Non-surgical treatment is instituted first.

Medical Therapy

  • Non-surgical treatment is instituted first
  • Physician may recommend any of the following:

Conservative therapy for Morton's neuroma

  • Morton's neuroma should be managed conservatively before proceeding to expensive diagnostic procedures
  • Conservative measures for pain relief include:[1][2][3][4][5][6]
    • Decreasing pressure on the metatarsal heads by using:
      • Metatarsal support
      • Metatarsal bars
      • Metatarsal pads
      • Padded shoe insert (it's important to place inserts properly just proximal to the metatarsal head)
      • Tapping the toe area
      • Orthotics
      • Specialized orthopedic shoes
      • Shoes with wider toe boxes allowing spread of metatarsal heads
      • Determine proper shoe width while standing with the help of a professional shoe fitting device
    • Physical therapy
    • Strength exercises for intrinsic foot muscles

Non-conservative medical therapy

References

  1. ↑ Kang JH, Chen MD, Chen SC, Hsi WL (2006). "Correlations between subjective treatment responses and plantar pressure parameters of metatarsal pad treatment in metatarsalgia patients: a prospective study". BMC Musculoskelet Disord. 7: 95. doi:10.1186/1471-2474-7-95. PMC 1712337. PMID 17147793.
  2. ↑ Jannink M, van Dijk H, Ijzerman M, Groothuis-Oudshoorn K, Groothoff J, Lankhurst G (2006). "Effectiveness of custom-made orthopaedic shoes in the reduction of foot pain and pressure in patients with degenerative disorders of the foot". Foot Ankle Int. 27 (11): 974–9. doi:10.1177/107110070602701119. PMID 17144963.
  3. ↑ Hsi WL, Kang JH, Lee XX (2005). "Optimum position of metatarsal pad in metatarsalgia for pressure relief". Am J Phys Med Rehabil. 84 (7): 514–20. PMID 15973088.
  4. ↑ Jackson L, Binning J, Potter J (2004). "Plantar pressures in rheumatoid arthritis using prefabricated metatarsal padding". J Am Podiatr Med Assoc. 94 (3): 239–45. PMID 15153584.
  5. ↑ Chang AH, Abu-Faraj ZU, Harris GF, Nery J, Shereff MJ (1994). "Multistep measurement of plantar pressure alterations using metatarsal pads". Foot Ankle Int. 15 (12): 654–60. doi:10.1177/107110079401501205. PMID 7894637.
  6. ↑ Holmes GB, Timmerman L (1990). "A quantitative assessment of the effect of metatarsal pads on plantar pressures". Foot Ankle. 11 (3): 141–5. PMID 2074081.
  7. ↑ Neuroma. Radiopedia http://radiopaedia.org/cases/morton-neuroma-2 Accessed on April 21, 2016
  8. ↑ Malessy MJA, de Boer R, Muñoz Romero I, Eekhof JLA, van Zwet EW, Kliot M; et al. (2018). "Predictive value of a diagnostic block in focal nerve injury with neuropathic pain when surgery is considered". PLoS One. 13 (9): e0203345. doi:10.1371/journal.pone.0203345. PMC 6135496. PMID 30208078.
  9. ↑ Climent JM, Mondéjar-Gómez F, Rodríguez-Ruiz C, Díaz-Llopis I, Gómez-Gallego D, Martín-Medina P (2013). "Treatment of Morton neuroma with botulinum toxin A: a pilot study". Clin Drug Investig. 33 (7): 497–503. doi:10.1007/s40261-013-0090-0. PMC 3691490. PMID 23740337.
  10. ↑ Thomson CE, Beggs I, Martin DJ, McMillan D, Edwards RT, Russell D; et al. (2013). "Methylprednisolone injections for the treatment of Morton neuroma: a patient-blinded randomized trial". J Bone Joint Surg Am. 95 (9): 790–8, S1. doi:10.2106/JBJS.I.01780. PMID 23636185.
  11. ↑ Schon L (2014). "An injection of corticosteroid plus anesthetic was more effective than anesthetic alone for Morton neuroma". J Bone Joint Surg Am. 96 (4): 334. doi:10.2106/JBJS.9604.ebo028. PMID 24553891.
  12. ↑ Smith RW (2013). "Steroid injection for Morton neuroma - data-based justification". J Bone Joint Surg Am. 95 (9): e64. doi:10.2106/JBJS.M.00172. PMID 23636203.
  13. ↑ Haddad-Zebouni S, Elia D, Aoun N, Okais J, Ghossain M (2006). "[Regression of Morton neuroma after local injection of steroids]". J Radiol. 87 (5): 566–8. PMID 16733414.
  14. ↑ Basadonna PT, Rucco V, Gasparini D, Onorato A (1999). "Plantar fat pad atrophy after corticosteroid injection for an interdigital neuroma: a case report". Am J Phys Med Rehabil. 78 (3): 283–5. PMID 10340428.
  15. ↑ Reddy PD, Zelicof SB, Ruotolo C, Holder J (1995). "Interdigital neuroma. Local cutaneous changes after corticosteroid injection". Clin Orthop Relat Res (317): 185–7. PMID 7671475.
  16. ↑ van Vendeloo SN, Ettema HB (2016). "Skin depigmentation along lymph vessels of the lower leg following local corticosteroid injection for interdigital neuroma". Foot Ankle Surg. 22 (2): 139–41. doi:10.1016/j.fas.2016.01.002. PMID 27301735.
  17. ↑ Park YH, Lee JW, Choi GW, Kim HJ (2018). "Risk factors and the associated cutoff values for failure of corticosteroid injection in treatment of Morton's neuroma". Int Orthop. 42 (2): 323–329. doi:10.1007/s00264-017-3707-8. PMID 29230531.
  18. ↑ Mahadevan D, Salmasi M, Whybra N, Nanda A, Gaba S, Mangwani J (2016). "What factors predict the need for further intervention following corticosteroid injection of Morton's neuroma?". Foot Ankle Surg. 22 (1): 9–11. doi:10.1016/j.fas.2015.03.007. PMID 26869493.
  19. ↑ Mahadevan D, Attwal M, Bhatt R, Bhatia M (2016). "Corticosteroid injection for Morton's neuroma with or without ultrasound guidance: a randomised controlled trial". Bone Joint J. 98-B (4): 498–503. doi:10.1302/0301-620X.98B4.36880. PMID 27037432.
  20. ↑ Yap LP, McNally E (2012). "Patient's assessment of discomfort during ultrasound-guided injection of Morton's neuroma: selecting the optimal approach". J Clin Ultrasound. 40 (6): 330–4. doi:10.1002/jcu.21926. PMID 22585530.
  21. ↑ Hughes RJ, Ali K, Jones H, Kendall S, Connell DA (2007). "Treatment of Morton's neuroma with alcohol injection under sonographic guidance: follow-up of 101 cases". AJR Am J Roentgenol. 188 (6): 1535–9. doi:10.2214/AJR.06.1463. PMID 17515373.
  22. ↑ Wu KK (1996). "Morton's interdigital neuroma: a clinical review of its etiology, treatment, and results". J Foot Ankle Surg. 35 (2): 112–9, discussion 187-8. PMID 8722878.
  23. ↑ Rasmussen MR, Kitaoka HB, Patzer GL (1996). "Nonoperative treatment of plantar interdigital neuroma with a single corticosteroid injection". Clin Orthop Relat Res (326): 188–93. doi:10.1097/00003086-199605000-00022. PMID 8620640.
  24. ↑ Markovic M, Crichton K, Read JW, Lam P, Slater HK (2008). "Effectiveness of ultrasound-guided corticosteroid injection in the treatment of Morton's neuroma". Foot Ankle Int. 29 (5): 483–7. doi:10.3113/FAI.2008.0483. PMID 18510900.
  25. ↑ Sofka CM, Adler RS, Ciavarra GA, Pavlov H (2007). "Ultrasound-guided interdigital neuroma injections: short-term clinical outcomes after a single percutaneous injection--preliminary results". HSS J. 3 (1): 44–9. doi:10.1007/s11420-006-9029-9. PMC 2504098. PMID 18751769.
  26. ↑ Hassouna H, Singh D, Taylor H, Johnson S (2007). "Ultrasound guided steroid injection in the treatment of interdigital neuralgia". Acta Orthop Belg. 73 (2): 224–9. PMID 17515235.


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