Palmar plantar erythrodysesthesia pathophysiology: Difference between revisions
Jump to navigation
Jump to search
Mchitsazan (talk | contribs) No edit summary |
Mchitsazan (talk | contribs) |
||
| Line 15: | Line 15: | ||
}}</ref> | }}</ref> | ||
* Concentration and excretion of cytotoxic drug in eccrine sweat glands causing damage or alteration in these structures <ref>{{ | * Concentration and excretion of cytotoxic drug in eccrine sweat glands causing damage or alteration in these structures <ref name="pmid2061446">{{cite journal| author=Baack BR, Burgdorf WH| title=Chemotherapy-induced acral erythema. | journal=J Am Acad Dermatol | year= 1991 | volume= 24 | issue= 3 | pages= 457-61 | pmid=2061446 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2061446 }} </ref> <ref>{{Cite journal | ||
}}</ref> <ref>{{Cite journal | |||
| author = [[Hiromi Tsuboi]], [[Kohzoh Yonemoto]] & [[Kensei Katsuoka]] | | author = [[Hiromi Tsuboi]], [[Kohzoh Yonemoto]] & [[Kensei Katsuoka]] | ||
| title = A case of bleomycin-induced acral erythema (AE) with eccrine squamous syringometaplasia (ESS) and summary of reports of AE with ESS in the literature | | title = A case of bleomycin-induced acral erythema (AE) with eccrine squamous syringometaplasia (ESS) and summary of reports of AE with ESS in the literature | ||
| Line 29: | Line 24: | ||
* A type I (immunoglobulin E [IgE]-mediated) allergic reaction <ref>{{cite book | last = Perry | first = Michael | title = Chemotherapy source book | publisher = Wolters Kluwer Health/Lippincott Williams & Wilkins | location = Philadelphia | year = 2012 | isbn = 9781451101454 }}</ref>, suggested based on the occasional co-occurrence of facial erythema/edema, papular rash, and fever. | * A type I (immunoglobulin E [IgE]-mediated) allergic reaction <ref>{{cite book | last = Perry | first = Michael | title = Chemotherapy source book | publisher = Wolters Kluwer Health/Lippincott Williams & Wilkins | location = Philadelphia | year = 2012 | isbn = 9781451101454 }}</ref>, suggested based on the occasional co-occurrence of facial erythema/edema, papular rash, and fever. | ||
Unique characteristics of the palms and the soles which justify their involvement as the preferred sites of involvement include <ref>{{ | Unique characteristics of the palms and the soles which justify their involvement as the preferred sites of involvement include <ref name="pmid2061446">{{cite journal| author=Baack BR, Burgdorf WH| title=Chemotherapy-induced acral erythema. | journal=J Am Acad Dermatol | year= 1991 | volume= 24 | issue= 3 | pages= 457-61 | pmid=2061446 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2061446 }} </ref> <ref>{{Cite journal | ||
}}</ref> <ref>{{Cite journal | |||
| author = [[W. S. Susser]], [[D. L. Whitaker-Worth]] & [[J. M. Grant-Kels]] | | author = [[W. S. Susser]], [[D. L. Whitaker-Worth]] & [[J. M. Grant-Kels]] | ||
| title = Mucocutaneous reactions to chemotherapy | | title = Mucocutaneous reactions to chemotherapy | ||
Revision as of 22:21, 26 June 2019
|
Palmar plantar erythrodysesthesia Microchapters |
|
Differentiating Palmar plantar erythrodysesthesia from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Palmar plantar erythrodysesthesia pathophysiology On the Web |
|
American Roentgen Ray Society Images of Palmar plantar erythrodysesthesia pathophysiology |
|
Palmar plantar erythrodysesthesia pathophysiology in the news |
|
Directions to Hospitals Treating Palmar plantar erythrodysesthesia |
|
Risk calculators and risk factors for Palmar plantar erythrodysesthesia pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mandana Chitsazan, M.D.
Overview
Pathophysiology
The exact pathogenesis of palmar plantar dysesthesia is not completely understood. Suggested explanations include:
- Direct toxic effect of the chemotherapeutic drug against epidermal cells (keratinocytes)[1]
- Concentration and excretion of cytotoxic drug in eccrine sweat glands causing damage or alteration in these structures [2] [3]
- A type I (immunoglobulin E [IgE]-mediated) allergic reaction [4], suggested based on the occasional co-occurrence of facial erythema/edema, papular rash, and fever.
Unique characteristics of the palms and the soles which justify their involvement as the preferred sites of involvement include [2] [5] [6]
- High density of eccrine sweat glands [7]
- Absence of folliculosebaceous units (hair follicles and sebaceous glands)[7]
- Thick stratum corneum [7]
- Wide dermal papillae [7]
- High proliferation rate of epidermal basal cells
- The temperature and pressure gradient
- Gravitation forces
- Vascular anatomy peculiar to these areas
- In cases caused by capecitabine, higher expression of the capecitabine-activating enzyme thymidine phosphorylase in the skin of the palms10
Gross Pathology
On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
Microscopic Pathology
On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
References
- ↑ J. E. Fitzpatrick. "The cutaneous histopathology of chemotherapeutic reactions". Journal of cutaneous pathology. PMID 8468414.
- ↑ 2.0 2.1 Baack BR, Burgdorf WH (1991). "Chemotherapy-induced acral erythema". J Am Acad Dermatol. 24 (3): 457–61. PMID 2061446.
- ↑ Hiromi Tsuboi, Kohzoh Yonemoto & Kensei Katsuoka. "A case of bleomycin-induced acral erythema (AE) with eccrine squamous syringometaplasia (ESS) and summary of reports of AE with ESS in the literature". The Journal of dermatology. PMID 16361756.
- ↑ Perry, Michael (2012). Chemotherapy source book. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. ISBN 9781451101454.
- ↑ W. S. Susser, D. L. Whitaker-Worth & J. M. Grant-Kels. "Mucocutaneous reactions to chemotherapy". Journal of the American Academy of Dermatology. PMID 10071309.
- ↑ Yvonne Lassere & Paulo Hoff. "Management of hand-foot syndrome in patients treated with capecitabine (Xeloda)". European journal of oncology nursing : the official journal of European Oncology Nursing Society. doi:10.1016/j.ejon.2004.06.007. PMID 15341880.
- ↑ 7.0 7.1 7.2 7.3 Cox GJ, Robertson DB (1986). "Toxic erythema of palms and soles associated with high-dose mercaptopurine chemotherapy". Arch Dermatol. 122 (12): 1413–4. PMID 2947543.