Follicular thyroid cancer pathophysiology: Difference between revisions

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==Gross Pathology==
==Gross Pathology==
* Encapsulated tumors
* Encapsulated tumors
[[Image:Follicular adenoma of the thyroid.jpg|thumb|center|Gross pathological section of a follicular thyroid carcinoma (tumor at the bottom).]]
[[File:Folladen.jpg|thumb|left|Gross pathological section of a follicular thyroid carcinoma (tumor at the bottom).]]
 
==Microscopic Pathology==
==Microscopic Pathology==



Revision as of 15:19, 18 July 2019

Follicular thyroid cancer Microchapters

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Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Follicular thyroid cancer from other Diseases

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Overview

Follicular thyroid cancer arises from follicular cells of thyroid, which are secretory cells that are normally involved in production and secretion of thyroid hormones, thyroxine (T4) and triiodothyronine (T3). Genes involved in the pathogenesis of follicular thyroid cancer include RAS, PAX8/PPARγ, and PTEN.

Pathogenesis

  • Follicular thyroid cancer is the second most common type of cancer. It constitutes about 15% of thyroid cancers.
Pathogenesis of follicular thyroid carcinoma





























Genetics

  • The Ras oncogene is positive in a significant proportion of individuals.
  • The Ras oncogene acts through the RAF-MEK-MAPK kinase pathway.
  • Other genes involved in the pathogenesis of follicular thyroid cancer are:
Schema of key pathways in the development and progression of thyroid cancer.

Associated Conditions

Gross Pathology

  • Encapsulated tumors
Gross pathological section of a follicular thyroid carcinoma (tumor at the bottom).

Microscopic Pathology

Histopathological Video

Video

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References

  1. Aytug, Serhat (June 13, 2006). "Hurthle Cell Carcinoma". eMedicine. Check date values in: |date= (help)
  2. http://librepathology.org/wiki/index.php/File:Metastatic_follicular_thyroid_carcinoma_-_Case_264_(8558730243).jpg Accessed on October, 29 2015
  3. http://librepathology.org/wiki/index.php/File:Metastatic_follicular_thyroid_carcinoma_-_Case_264_(8559837390).jpg Accessed on October, 29 2015