Progeria history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]

Overview

The majority of patients with [disease name] are asymptomatic.

OR

The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. Common symptoms of [disease] include [symptom 1], [symptom 2], and [symptom 3]. Less common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].

History and Symptoms

• The majority of patients with Hutchinson-Gilford progeria syndrome (HGPS) are asymptomatic in the first few months of life.
• In patients with Hutchinson-Gilford progeria syndrome (HGPS) symptoms starts to appear in the first few years of life.

History

Patients with Hutchinson-Gilford progeria syndrome (HGPS) may have a positive history of:

• Growth issues
• Musculoskeletal problems
• Cardiac issues
• Neurologic issues
• Ophthalmologic problems
• Hearing problems

Common Symptoms

Common symptoms of [disease] include:

• Failure to thrive
• Loss of subcutaneous fat
• Poor weight gain
• Short stature,
• Joint contractures
• Alopecia
• Micrognathia
• Retrognathia
• Prominent scalp veins

Less Common Symptoms

Less common symptoms of [disease name] include

• Hyper/hypopigmentation
• Dystrophic fingernails
• Dystrophic toenails