Ovarian cancer classification: Difference between revisions

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==Classification==
==Classification==
Histology dictates many aspects of clinical treatment, management, and [[prognosis]]. <ref name="pmid11385772">{{cite journal| author=Heintz AP, Odicino F, Maisonneuve P, Beller U, Benedet JL, Creasman WT et al.| title=Carcinoma of the ovary. | journal=J Epidemiol Biostat | year= 2001 | volume= 6 | issue= 1 | pages= 107-38 | pmid=11385772 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11385772  }} </ref><ref name="pmid21340753">{{cite journal| author=Banks E| title=The epidemiology of ovarian cancer. | journal=Methods Mol Med | year= 2001 | volume= 39 | issue=  | pages= 3-11 | pmid=21340753 | doi=10.1385/1-59259-071-3:3 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21340753  }} </ref><ref name="pmid12644542">{{cite journal| author=Singer G, Oldt R, Cohen Y, Wang BG, Sidransky D, Kurman RJ et al.| title=Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma. | journal=J Natl Cancer Inst | year= 2003 | volume= 95 | issue= 6 | pages= 484-6 | pmid=12644542 | doi=10.1093/jnci/95.6.484 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12644542  }} </ref><ref name="pmid15644779">{{cite journal| author=Singer G, Stöhr R, Cope L, Dehari R, Hartmann A, Cao DF et al.| title=Patterns of p53 mutations separate ovarian serous borderline tumors and low- and high-grade carcinomas and provide support for a new model of ovarian carcinogenesis: a mutational analysis with immunohistochemical correlation. | journal=Am J Surg Pathol | year= 2005 | volume= 29 | issue= 2 | pages= 218-24 | pmid=15644779 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15644779  }} </ref>
*[[Surface epithelial-stromal tumor]], including serous and mucinous [[cystadenocarcinoma]], is the most common type of ovarian cancer.
*[[Sex cord-stromal tumour|Sex cord-stromal tumor]], including [[estrogen]]-producing [[granulosa cell tumor]] and '''virilizing''' [[Sertoli-Leydig cell tumor]] or [[arrhenoblastoma]], accounts for 8% of ovarian cancers.
*[[Germ cell tumor]] accounts for approximately 5% of ovarian cancers. It tends to occur in young women and girls, and has a better prognosis than other ovarian tumors.
*'''Mixed''' tumors, containing elements of more than one tumor histology
Ovarian cancer often is '''primary''', but can also be '''secondary''', the result of [[metastasis]] from a primary cancer elsewhere in the body.  For example, from [[breast cancer]], or from [[gastrointestinal cancer]] (in which case the ovarian cancer is a [[Krukenberg cancer]]).  Surface epithelial-stromal tumor can originate in the lining of the abdominal cavity, in which case the ovarian cancer is secondary to [[primary peritoneal cancer]], but treatment is basically the same as for primary ovarian cancer of this type.
Cellular Classification of Ovarian tumor http://radiopaedia.org/articles/ovarian-tumours
<br />
{| style="border: 0px; font-size: 90%; margin: 4px;" align="center"
{| style="border: 0px; font-size: 90%; margin: 4px;" align="center"
! style="background: #4479BA; padding: 5px 5px;" rowspan=1 | {{fontcolor|#FFFFFF| Ovarian cancer Types}}
! style="background: #4479BA; padding: 5px 5px;" rowspan=1 | {{fontcolor|#FFFFFF| Ovarian cancer Types}}
! style="background: #4479BA; padding: 5px 5px;" rowspan=1 | {{fontcolor|#FFFFFF| Ovarian cancer subtypes }}
! style="background: #4479BA; padding: 5px 5px;" rowspan=1 | {{fontcolor|#FFFFFF| Ovarian cancer subtypes }}
|-
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold;" rowspan="20;" | [[Surface epithelial-stromal tumour]]
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold;" rowspan="20;" | [[Surface epithelial-stromal tumour]] (60-70%)
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold;" rowspan="1;"|Ovarian serous tumor
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold;" rowspan="1;"|Ovarian serous tumor
|-
|-
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold;" rowspan="1;"|Malignant mixed germ cell tumour of the ovary
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold;" rowspan="1;"|Malignant mixed germ cell tumour of the ovary
|-
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold;" rowspan="12;" | Sex cord / stromal ovarian tumor (8-10%)
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold;" rowspan="12;" | Sex cord / stromal ovarian tumor (8-10%)<ref name="pmid12733128">{{cite journal| author=Chen VW, Ruiz B, Killeen JL, Coté TR, Wu XC, Correa CN| title=Pathology and classification of ovarian tumors. | journal=Cancer | year= 2003 | volume= 97 | issue= 10 Suppl | pages= 2631-42 | pmid=12733128 | doi=10.1002/cncr.11345 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12733128  }} </ref><ref name="pmid15502809">{{cite journal| author=Young RH| title=Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems. | journal=Mod Pathol | year= 2005 | volume= 18 Suppl 2 | issue=  | pages= S81-98 | pmid=15502809 | doi=10.1038/modpathol.3800311 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15502809  }} </ref>
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold;" rowspan="1;"|Ovarian fibrothecoma
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold;" rowspan="1;"|Ovarian fibrothecoma
|-
|-
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|}
|}


 
:*[[Category:Up-To-Date]] [[Category:Oncology]] [[Category:Medicine]] [[Category:Gynecology]] [[Category:Surgery]]
{| style="border: 0px; font-size: 90%; margin: 4px;" align="center"
! style="background: #4479BA; padding: 5px 5px;" rowspan=1 | {{fontcolor|#FFFFFF| Ovarian cancer Types}}
! style="background: #4479BA; padding: 5px 5px;" rowspan=1 | {{fontcolor|#FFFFFF| Ovarian cancer subtypes }}
! style="background: #4479BA; padding: 5px 5px;" rowspan=1 | {{fontcolor|#FFFFFF|Ovarian cancer sub- subtypes}}
! style="background: #4479BA; padding: 5px 5px;" rowspan=1 | {{fontcolor|#FFFFFF| Characterestics}}
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold;" rowspan="13;" | [[Surface epithelial-stromal tumour]]
| style="padding: 5px 5px; background: #F5F5F5; font-weight: bold;" rowspan="3;"|Ovarian serous tumor
| style="padding: 5px 5px; background: #F5F5F5;" |[[Ovarian serous cystadenoma]]
| style="padding: 5px 5px; background: #F5F5F5;" |~60% of serous tumor
|-
| style="padding: 5px 5px; background: #F5F5F5;" |[[Ovarian borderline serous cystadenoma]]
| style="padding: 5px 5px; background: #F5F5F5;" |~15% of serous tumor
|-
| style="padding: 5px 5px; background: #F5F5F5;" |[[Ovarian serous cystadenocarcinoma]]
| style="padding: 5px 5px; background: #F5F5F5;" |~25% of serous tumor; commonest malignant ovarian tumour
|-
| style="padding: 5px 5px; background: #F5F5F5; font-weight: bold;" rowspan="3;"|Ovarian mucinous tumor
| style="padding: 5px 5px; background: #F5F5F5;" |[[Ovarian mucinous cystadenoma]]
| style="padding: 5px 5px; background: #F5F5F5;" |~80% of mucinous tumor
|-
| style="padding: 5px 5px; background: #F5F5F5;" |[[Ovarian borderline mucinous cystadenoma]]
| style="padding: 5px 5px; background: #F5F5F5;" |10-15% of mucinous tumor
|-
| style="padding: 5px 5px; background: #F5F5F5;" |[[Ovarian mucinous cystadenocarcinoma]]
| style="padding: 5px 5px; background: #F5F5F5;" |~5-10% of serous tumor
|-
| style="padding: 5px 5px; background: #F5F5F5; font-weight: bold;" rowspan=";"|Ovarian endometrioid tumour
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |8-15% of all ovarian tumor
|-
| style="padding: 5px 5px; background: #F5F5F5; font-weight: bold;" rowspan="1;"|[[Brenner tumour]]
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" | ~2.5% of ovarian epithelial neoplasms
|-
| style="padding: 5px 5px; background: #F5F5F5; font-weight: bold;" rowspan="1;"|Squamous cell carcinoma of the ovary
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |~5% of ovarian cancer
|-
| style="padding: 5px 5px; background: #F5F5F5; font-weight: bold;" rowspan="1;"|Ovarian cystadenofibroma / ovarian adenofibroma
| style="padding: 5px 5px; background: #F5F5F5;" |[[can be serous, mucinous, endometrioid, clear cell or mixed]]
| style="padding: 5px 5px; background: #F5F5F5;" |
|-
| style="padding: 5px 5px; background: #F5F5F5; font-weight: bold;" rowspan="1;"|Ovarian cystadenocarcinofibroma:
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" | extremely rare
|-
| style="padding: 5px 5px; background: #F5F5F5; font-weight: bold;" rowspan="1;"|Undifferentiated carcinoma of the ovary: 
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" | ~4% of all ovarian tumor:
|-
| style="padding: 5px 5px; background: #F5F5F5; font-weight: bold;" rowspan="1;"|Undifferentiated carcinoma of the ovary: 
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" | ~4% of all ovarian tumor:
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold;" rowspan="11;" | [[Germ cell ovarian tumor (~20%)]]
| style="padding: 5px 5px; background: #F5F5F5; font-weight: bold;" rowspan="5;"|Ovarian teratoma: commonest primary benign tumour of ovary
| style="padding: 5px 5px; background: #F5F5F5;" |[[Mature ovarian (cystic) teratoma]]
| style="padding: 5px 5px; background: #F5F5F5;" |
|-
| style="padding: 5px 5px; background: #F5F5F5;" |[[Immature ovarian teratoma]]
| style="padding: 5px 5px; background: #F5F5F5;" |
|-
| style="padding: 5px 5px; background: #F5F5F5;" |[[Specialised teratomas of the ovary]]
| style="padding: 5px 5px; background: #F5F5F5;" |
|-
| style="padding: 5px 5px; background: #F5F5F5;" |[[Struma ovarii tumour]]
| style="padding: 5px 5px; background: #F5F5F5;" |
|-
| style="padding: 5px 5px; background: #F5F5F5;" |[[Ovarian carcinoid tumor]]
| style="padding: 5px 5px; background: #F5F5F5;" |
|-
| style="padding: 5px 5px; background: #F5F5F5; font-weight: bold;" rowspan="1;"| Ovarian dysgerminoma
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
|-
| style="padding: 5px 5px; background: #F5F5F5; font-weight: bold;" rowspan="1;"| Ovarian yolk sac tumour:
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |endodermal sinus tumour
|-
| style="padding: 5px 5px; background: #F5F5F5; font-weight: bold;" rowspan="1;"| Ovarian embryonal carcinoma
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
|-
| style="padding: 5px 5px; background: #F5F5F5; font-weight: bold;" rowspan="1;"| Ovarian choriocarcinoma: <1% of ovarian tumor
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
|-
| style="padding: 5px 5px; background: #F5F5F5; font-weight: bold;" rowspan="1;"| Pure primary ovarian choriocarcinoma:
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |  extremely rare
|-
| style="padding: 5px 5px; background: #F5F5F5; font-weight: bold;" rowspan="1;"| Malignant mixed germ cell tumour of the ovary
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold;" rowspan="8;" | [[Sex cord / stromal ovarian tumor (8-10%)]]
| style="padding: 5px 5px; background: #F5F5F5; font-weight: bold;" rowspan="1;"|[[Ovarian fibrothecoma]]
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |~5% of ovarian tumor
|-
| style="padding: 5px 5px; background: #F5F5F5; font-weight: bold;" rowspan="1;"|[[Ovarian fibroma]]
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |~4% of ovarian tumor
|-
| style="padding: 5px 5px; background: #F5F5F5; font-weight: bold;" rowspan="1;"|[[Sclerosing stromal tumour of the ovary: ]]
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |rare
|-
| style="padding: 5px 5px; background: #F5F5F5; font-weight: bold;" rowspan="1;"|Ovarian Sertoli-Leydig cell tumour - ovarian androblastoma:
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" | ~0.5% of ovarian tumor
|-
| style="padding: 5px 5px; background: #F5F5F5; font-weight: bold;" rowspan="1;"|Granulosa cell tumour of ovary:
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" | commonest malignant sex cord tumour
|-
| style="padding: 5px 5px; background: #F5F5F5; font-weight: bold;" rowspan="1;"|Juvenile granulosa cell tumour of ovary
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
|-
| style="padding: 5px 5px; background: #F5F5F5; font-weight: bold;" rowspan="1;"|Adult granulosa cell tumour of ovary
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
|-
| style="padding: 5px 5px; background: #F5F5F5; font-weight: bold;" rowspan="1;"|Mixed
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold;" rowspan="3;" | [[Others)]]
| style="padding: 5px 5px; background: #F5F5F5; font-weight: bold;" rowspan="1;"|Ovarian carcinosarcoma <1%
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
|-
| style="padding: 5px 5px; background: #F5F5F5; font-weight: bold;" rowspan="2;"|Ovarian lymphoma
| style="padding: 5px 5px; background: #F5F5F5;" |[[Primary ovarian lymphoma]]
| style="padding: 5px 5px; background: #F5F5F5;" |
|-
| style="padding: 5px 5px; background: #F5F5F5;" |[[Secondary involvement of the ovary with lymphoma]]
| style="padding: 5px 5px; background: #F5F5F5;" |
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold;" rowspan="2;" | [[Metastases to the ovary)]]
| style="padding: 5px 5px; background: #F5F5F5; font-weight: bold;" rowspan="1;"|Krukenburg tumour
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
|-
| style="padding: 5px 5px; background: #F5F5F5; font-weight: bold;" rowspan="1;"|Other metastatic lesions to ovary
| style="padding: 5px 5px; background: #F5F5F5;" |
| style="padding: 5px 5px; background: #F5F5F5;" |
 
 
 
Other
 
 
 
 
 
|}
 
 
{| style="border: 0px; font-size: 90%; margin: 3px;" align="center"
! style="background: #4479BA; padding: 5px 5px;" rowspan=1 | {{fontcolor|#FFFFFF| Ovarian cancer Types}}
! style="background: #4479BA; padding: 5px 5px;" rowspan=1 | {{fontcolor|#FFFFFF| Ovarian cancer subtypes }}
! style="background: #4479BA; padding: 5px 5px;" rowspan=1 | {{fontcolor|#FFFFFF| Characterestics}}
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold;|[[Surface epithelial-stromal tumour]]
| style="padding: 5px 5px; background: #F5F5F5;" |Ovarian serous tumor
<br />
| style="padding: 5px 5px; background: #F5F5F5;" |
*Ovarian serous cystadenoma: ~60% of serous tumor
* Ovarian borderline serous cystadenoma: ~15% of serous tumor
* Ovarian serous cystadenocarcinoma: ~25% of serous tumor; commonest malignant ovarian tumour
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold;|
| style="padding: 5px 5px; background: #F5F5F5;" |
*Ovarian mucinous tumor: ~20% of all ovarian tumor
| style="padding: 5px 5px; background: #F5F5F5;" |
:* Ovarian mucinous cystadenoma: ~80% of mucinous tumor
:* Ovarian bordeline mucinous cystadenoma: 10-15% of mucinous tumor
:* Ovarian mucinous cystadenocarcinoma: 5-10% of mucinous tumor
|-
|}
 
Histology dictates many aspects of clinical treatment, management, and [[prognosis]]. <ref name="pmid11385772">{{cite journal| author=Heintz AP, Odicino F, Maisonneuve P, Beller U, Benedet JL, Creasman WT et al.| title=Carcinoma of the ovary. | journal=J Epidemiol Biostat | year= 2001 | volume= 6 | issue= 1 | pages= 107-38 | pmid=11385772 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11385772  }} </ref><ref name="pmid21340753">{{cite journal| author=Banks E| title=The epidemiology of ovarian cancer. | journal=Methods Mol Med | year= 2001 | volume= 39 | issue=  | pages= 3-11 | pmid=21340753 | doi=10.1385/1-59259-071-3:3 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21340753  }} </ref><ref name="pmid12644542">{{cite journal| author=Singer G, Oldt R, Cohen Y, Wang BG, Sidransky D, Kurman RJ et al.| title=Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma. | journal=J Natl Cancer Inst | year= 2003 | volume= 95 | issue= 6 | pages= 484-6 | pmid=12644542 | doi=10.1093/jnci/95.6.484 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12644542  }} </ref><ref name="pmid15644779">{{cite journal| author=Singer G, Stöhr R, Cope L, Dehari R, Hartmann A, Cao DF et al.| title=Patterns of p53 mutations separate ovarian serous borderline tumors and low- and high-grade carcinomas and provide support for a new model of ovarian carcinogenesis: a mutational analysis with immunohistochemical correlation. | journal=Am J Surg Pathol | year= 2005 | volume= 29 | issue= 2 | pages= 218-24 | pmid=15644779 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15644779  }} </ref>
 
*[[Surface epithelial-stromal tumor]], including serous and mucinous [[cystadenocarcinoma]], is the most common type of ovarian cancer.
*[[Sex cord-stromal tumour|Sex cord-stromal tumor]], including [[estrogen]]-producing [[granulosa cell tumor]] and '''virilizing''' [[Sertoli-Leydig cell tumor]] or [[arrhenoblastoma]], accounts for 8% of ovarian cancers.
*[[Germ cell tumor]] accounts for approximately 5% of ovarian cancers. It tends to occur in young women and girls, and has a better prognosis than other ovarian tumors.
* '''Mixed''' tumors, containing elements of more than one tumor histology
 
Ovarian cancer often is '''primary''', but can also be '''secondary''', the result of [[metastasis]] from a primary cancer elsewhere in the body.  For example, from [[breast cancer]], or from [[gastrointestinal cancer]] (in which case the ovarian cancer is a [[Krukenberg cancer]]).  Surface epithelial-stromal tumor can originate in the lining of the abdominal cavity, in which case the ovarian cancer is secondary to [[primary peritoneal cancer]], but treatment is basically the same as for primary ovarian cancer of this type.
 
Cellular Classification of Ovarian tumor http://radiopaedia.org/articles/ovarian-tumours
 
==Ovarian tumor==
* '''Surface epithelial stromal ovarian tumor''' (60-70%)
 
:* Ovarian serous tumor
::* Ovarian serous cystadenoma: ~60% of serous tumor
::* Ovarian borderline serous cystadenoma: ~15% of serous tumor
::* Ovarian serous cystadenocarcinoma: ~25% of serous tumor; commonest malignant ovarian tumour
:* Ovarian mucinous tumor: ~20% of all ovarian tumor
::* Ovarian mucinous cystadenoma: ~80% of mucinous tumor
::* Ovarian bordeline mucinous cystadenoma: 10-15% of mucinous tumor
::* Ovarian mucinous cystadenocarcinoma: 5-10% of mucinous tumor
:* Ovarian endometrioid tumour: 8-15% of all ovarian tumor
:* Clear cell ovarian carcinoma: ~5% of ovarian cancer
:* Brenner tumour: ~2.5% of ovarian epithelial neoplasms
:* Squamous cell carcinoma of the ovary
:* Ovarian cystadenofibroma / ovarian adenofibroma: can be serous, mucinous, endometrioid, clear cell or mixed
:* Ovarian cystadenocarcinofibroma: extremely rare
:* Undifferentiated carcinoma of the ovary: ~4% of all ovarian tumor
* '''Germ cell ovarian tumor''' (~20%)
 
:* Ovarian teratoma: commonest primary benign tumour of ovary
::* Mature ovarian (cystic) teratoma
::* Immature ovarian teratoma
::* Specialised teratomas of the ovary
::* Struma ovarii tumour
::* Ovarian carcinoid tumor
:* Ovarian dysgerminoma
:* Ovarian yolk sac tumour: endodermal sinus tumour
:* Ovarian embryonal carcinoma
:* Ovarian choriocarcinoma: <1% of ovarian tumor
:* Pure primary ovarian choriocarcinoma: extremely rare
:* Malignant mixed germ cell tumour of the ovary
* '''Sex cord / stromal ovarian tumor''' (8-10%)<ref name="pmid12733128">{{cite journal| author=Chen VW, Ruiz B, Killeen JL, Coté TR, Wu XC, Correa CN| title=Pathology and classification of ovarian tumors. | journal=Cancer | year= 2003 | volume= 97 | issue= 10 Suppl | pages= 2631-42 | pmid=12733128 | doi=10.1002/cncr.11345 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12733128  }} </ref><ref name="pmid15502809">{{cite journal| author=Young RH| title=Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems. | journal=Mod Pathol | year= 2005 | volume= 18 Suppl 2 | issue=  | pages= S81-98 | pmid=15502809 | doi=10.1038/modpathol.3800311 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15502809  }} </ref>
 
:* Ovarian fibrothecoma: ~5% of ovarian tumor
:* Ovarian fibroma: ~4% of ovarian tumor
:* Ovarian thecoma: ~1% of ovarian tumor
:* Sclerosing stromal tumour of the ovary: rare
:* Ovarian Sertoli-Leydig cell tumour - ovarian androblastoma: ~0.5% of ovarian tumor
:* Granulosa cell tumour of ovary: commonest malignant sex cord tumour
:* Juvenile granulosa cell tumour of ovary
:* Adult granulosa cell tumour of ovary
:* Mixed
* Uncommon:
* Ovarian carcinosarcoma <1%
* Other
 
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Gynecology]]
[[Category:Surgery]]
:* Ovarian lymphoma
:* Primary ovarian lymphoma
:* Secondary involvement of the ovary with lymphoma
* Metastases to the ovary
 
:* Krukenburg tumour
:* Other metastatic lesions to ovary


==References==
==References==

Revision as of 17:18, 29 July 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Huda A. Karman, M.D.

Overview

Ovarian cancer is classified according to the histology of the tumor, obtained in a pathology report. Based on the classification, the management of ovarian cancer is directed and determined. The main four types of ovarian cancer are Surface epithelial-stromal tumour, Sex cord-stromal tumor, Germ cell tumor, and Mixed tumors.

Classification

Histology dictates many aspects of clinical treatment, management, and prognosis. [1][2][3][4]

Ovarian cancer often is primary, but can also be secondary, the result of metastasis from a primary cancer elsewhere in the body. For example, from breast cancer, or from gastrointestinal cancer (in which case the ovarian cancer is a Krukenberg cancer). Surface epithelial-stromal tumor can originate in the lining of the abdominal cavity, in which case the ovarian cancer is secondary to primary peritoneal cancer, but treatment is basically the same as for primary ovarian cancer of this type.

Cellular Classification of Ovarian tumor http://radiopaedia.org/articles/ovarian-tumours

Ovarian cancer Types Ovarian cancer subtypes
Surface epithelial-stromal tumour (60-70%) Ovarian serous tumor
  • Ovarian borderline serous cystadenoma: ~15% of serous tumor
  • Ovarian serous cystadenocarcinoma: ~25% of serous tumor; commonest malignant ovarian tumour
Ovarian mucinous tumor
  • Ovarian mucinous cystadenoma: ~80% of mucinous tumor
  • Ovarian borderline mucinous cystadenoma: 10-15% of mucinous tumor
  • Ovarian mucinous cystadenocarcinoma: ~5-10% of serous tumor
Ovarian endometrioid tumour
  • 8-15% of all ovarian tumor
Brenner tumour
  • ~2.5% of ovarian epithelial neoplasms
Squamous cell carcinoma of the ovary
  • ~5% of ovarian cancer
Ovarian cystadenofibroma / ovarian adenofibroma
  • can be serous, mucinous, endometrioid, clear cell or mixed
Ovarian cystadenocarcinofibroma
  • extremely rare
Undifferentiated carcinoma of the ovary
  • ~4% of all ovarian tumor
Germ cell ovarian tumor (~20%) Ovarian teratoma: commonest primary benign tumour of ovary
  • Immature ovarian teratoma
  • Mature ovarian (cystic) teratoma
  • Specialised teratomas of the ovary
  • Struma ovarii tumour
  • Ovarian carcinoid tumor
Ovarian dysgerminoma
Ovarian yolk sac tumour
  • endodermal sinus tumour
Ovarian embryonal carcinoma
Ovarian choriocarcinoma
  • <1% of ovarian tumor
Pure primary ovarian choriocarcinoma
  • extremely rare
Malignant mixed germ cell tumour of the ovary
Sex cord / stromal ovarian tumor (8-10%)[5][6] Ovarian fibrothecoma
  • ~5% of ovarian tumor
Ovarian fibroma
  • ~4% of ovarian tumor
Sclerosing stromal tumour of the ovary
  • rare
Ovarian Sertoli-Leydig cell tumour - ovarian androblastoma
  • ~0.5% of ovarian tumor
Granulosa cell tumour of ovary
  • commonest malignant sex cord tumour
Juvenile granulosa cell tumour of ovary
Adult granulosa cell tumour of ovary
Others Ovarian carcinosarcoma <1%
  • Primary ovarian lymphoma
  • Secondary involvement of the ovary with lymphoma
Metastases to the ovary Krukenburg tumour
Other metastatic lesions to ovary

References

  1. ↑ Heintz AP, Odicino F, Maisonneuve P, Beller U, Benedet JL, Creasman WT; et al. (2001). "Carcinoma of the ovary". J Epidemiol Biostat. 6 (1): 107–38. PMID 11385772.
  2. ↑ Banks E (2001). "The epidemiology of ovarian cancer". Methods Mol Med. 39: 3–11. doi:10.1385/1-59259-071-3:3. PMID 21340753.
  3. ↑ Singer G, Oldt R, Cohen Y, Wang BG, Sidransky D, Kurman RJ; et al. (2003). "Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma". J Natl Cancer Inst. 95 (6): 484–6. doi:10.1093/jnci/95.6.484. PMID 12644542.
  4. ↑ Singer G, Stöhr R, Cope L, Dehari R, Hartmann A, Cao DF; et al. (2005). "Patterns of p53 mutations separate ovarian serous borderline tumors and low- and high-grade carcinomas and provide support for a new model of ovarian carcinogenesis: a mutational analysis with immunohistochemical correlation". Am J Surg Pathol. 29 (2): 218–24. PMID 15644779.
  5. ↑ Chen VW, Ruiz B, Killeen JL, Coté TR, Wu XC, Correa CN (2003). "Pathology and classification of ovarian tumors". Cancer. 97 (10 Suppl): 2631–42. doi:10.1002/cncr.11345. PMID 12733128.
  6. ↑ Young RH (2005). "Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems". Mod Pathol. 18 Suppl 2: S81–98. doi:10.1038/modpathol.3800311. PMID 15502809.


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