Sandbox:Sara: Difference between revisions
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* Non-circumscribed | * Non-circumscribed | ||
* Highly cellular with cells having following characteristics: | * Highly [[cellular]] with [[Cells (biology)|cells]] having following [[Characteristic function (probability theory)|characteristics]]: | ||
** Monomorphic | ** Monomorphic | ||
** Thin | ** Thin | ||
** Spindly | **[[Spindle cells|Spindly]] | ||
** Scant eosinophilic cytoplasm | ** Scant [[eosinophilic]] [[cytoplasm]] | ||
** Hyperchromatic nuclei (resembling neurofibroma) | ** Hyperchromatic [[nuclei]] (resembling [[neurofibroma]]) | ||
* Tight storiform pattern (cells radiating in spokes at right angles around a central point that often contains a vessel) infiltrating deeply into subcutaneous tissue and entraping fat cells to form a characteristic honeycomb pattern | * Tight storiform [[pattern]] ([[Cells (biology)|cells]] [[Radiating fibers|radiating]] in spokes at right [[Angle|angles]] around a [[central]] [[Point (geometry)|point]] that often contains a [[Blood vessel|vessel]]) [[Infiltration (medical)|infiltrating]] deeply into [[subcutaneous tissue]] and entraping [[fat cells]] to form a [[Characteristic function (probability theory)|characteristic]] honeycomb [[pattern]] | ||
* Areas of fascicular growth (seen in some cases) | *[[Area|Areas]] of [[Fasciculus|fascicular]] [[growth]] (seen in some [[Case-based reasoning|cases]]) | ||
* The early plaque stage may lack the particular storiform pattern | * The early [[plaque]] stage may lack the particular storiform [[pattern]] | ||
* Many non-atypical mitotic figures may be present | * Many non-atypical [[mitotic]] figures may be present | ||
* Non-polarized, thin collagen | * Non-[[Polarization|polarized]], thin [[collagen]] | ||
* Mild pleomorphism (not significant) | * Mild [[pleomorphism]] (not [[Significant figure|significant]]) | ||
* Focal atypia | * Focal [[atypia]] | ||
* May coexist with giant cell fibroblastoma | * May coexist with [[giant cell]] fibroblastoma | ||
* Absent or rare histiocytes | * Absent or [[rare]] [[histiocytes]] | ||
* Following cell types are absent: | * Following [[Cell (biology)|cell]] types are absent: | ||
** Histiocyte-like cells | **[[Histiocyte]]-like [[Cells (biology)|cells]] | ||
** Foam cells | **[[Foam cells]] | ||
** Giant cells | **[[Giant cells]] | ||
** Other inflammatory cells | ** Other [[inflammatory cells]] | ||
* Different '''variants''' include: | * Different '''variants''' include: | ||
** Atrophic (depressed lesion) | **[[Atrophic]] ([[Depress|depressed]] [[lesion]]) | ||
** Collagenous (with central thick collagen bundles) | **[[Collagenous]] (with [[central]] thick [[collagen]] bundles) | ||
** Granular cell (S100 negative) | **[[Granular cell]] ([[S100A1|S100]] negative) | ||
** Myxoid | ** Myxoid | ||
** Palisading | ** Palisading | ||
** Pigmented | **[[Pigmented lesions|Pigmented]] | ||
** Sclerosing | ** Sclerosing | ||
Revision as of 23:05, 15 August 2019
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]
Microscopic features include:
- Non-circumscribed
- Highly cellular with cells having following characteristics:
- Monomorphic
- Thin
- Spindly
- Scant eosinophilic cytoplasm
- Hyperchromatic nuclei (resembling neurofibroma)
- Tight storiform pattern (cells radiating in spokes at right angles around a central point that often contains a vessel) infiltrating deeply into subcutaneous tissue and entraping fat cells to form a characteristic honeycomb pattern
- Areas of fascicular growth (seen in some cases)
- The early plaque stage may lack the particular storiform pattern
- Many non-atypical mitotic figures may be present
- Non-polarized, thin collagen
- Mild pleomorphism (not significant)
- Focal atypia
- May coexist with giant cell fibroblastoma
- Absent or rare histiocytes
- Following cell types are absent:
- Histiocyte-like cells
- Foam cells
- Giant cells
- Other inflammatory cells
- Different variants include:
- Atrophic (depressed lesion)
- Collagenous (with central thick collagen bundles)
- Granular cell (S100 negative)
- Myxoid
- Palisading
- Pigmented
- Sclerosing