Sandbox:Sara: Difference between revisions

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{{CMG}}; {{AE}} {{S.M.}}
{{CMG}}; {{AE}} {{S.M.}}


[[Microscopic]] [[Features (pattern recognition)|features]] include:
*Immunhistochemical staining of dermatofibrosarcoma protuberans shows:
 
**Positive staining for:
* Non-circumscribed
***CD34 (strong in 95%)
* Highly [[cellular]] with [[Cells (biology)|cells]] having following [[Characteristic function (probability theory)|characteristics]]:
***Vimentin
** Monomorphic
***Focal actin
** Thin
***ApoD<ref name="pmid15252314">{{cite journal| author=West RB, Harvell J, Linn SC, Liu CL, Prapong W, Hernandez-Boussard T et al.| title=Apo D in soft tissue tumors: a novel marker for dermatofibrosarcoma protuberans. | journal=Am J Surg Pathol | year= 2004 | volume= 28 | issue= 8 | pages= 1063-9 | pmid=15252314 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15252314  }} </ref><ref name="pmid17885669">{{cite journal| author=Lisovsky M, Hoang MP, Dresser KA, Kapur P, Bhawan J, Mahalingam M| title=Apolipoprotein D in CD34-positive and CD34-negative cutaneous neoplasms: a useful marker in differentiating superficial acral fibromyxoma from dermatofibrosarcoma protuberans. | journal=Mod Pathol | year= 2008 | volume= 21 | issue= 1 | pages= 31-8 | pmid=17885669 | doi=10.1038/modpathol.3800971 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17885669  }} </ref><ref name="pmid20062007">{{cite journal| author=Bandarchi B, Ma L, Marginean C, Hafezi S, Zubovits J, Rasty G| title=D2-40, a novel immunohistochemical marker in differentiating dermatofibroma from dermatofibrosarcoma protuberans. | journal=Mod Pathol | year= 2010 | volume= 23 | issue= 3 | pages= 434-8 | pmid=20062007 | doi=10.1038/modpathol.2009.176 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20062007  }} </ref>
**[[Spindle cells|Spindly]]
***bcl2
** Scant [[eosinophilic]] [[cytoplasm]]
***NKI-C3<ref name="pmid1553911">{{cite journal| author=Ma CK, Zarbo RJ, Gown AM| title=Immunohistochemical characterization of atypical fibroxanthoma and dermatofibrosarcoma protuberans. | journal=Am J Clin Pathol | year= 1992 | volume= 97 | issue= 4 | pages= 478-83 | pmid=1553911 | doi=10.1093/ajcp/97.4.478 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1553911  }} </ref>
** Hyperchromatic [[nuclei]] (resembling [[neurofibroma]])
***CD99<ref name="pmid18201229">{{cite journal| author=Diwan AH, Skelton HG, Horenstein MG, Kelly DR, Barrett TL, Bussian AH et al.| title=Dermatofibrosarcoma protuberans and giant cell fibroblastoma exhibit CD99 positivity. | journal=J Cutan Pathol | year= 2008 | volume= 35 | issue= 7 | pages= 647-50 | pmid=18201229 | doi=10.1111/j.1600-0560.2007.00872.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18201229  }} </ref>
* Tight storiform [[pattern]] ([[Cells (biology)|cells]] [[Radiating fibers|radiating]] in spokes at right [[Angle|angles]] around a [[central]] [[Point (geometry)|point]] that often contains a [[Blood vessel|vessel]]) [[Infiltration (medical)|infiltrating]] deeply into [[subcutaneous tissue]] and entraping [[fat cells]] to form a [[Characteristic function (probability theory)|characteristic]] honeycomb [[pattern]]
***Nestin
*[[Area|Areas]] of [[Fasciculus|fascicular]] [[growth]] (seen in some [[Case-based reasoning|cases]])
***Tenascin
* The early [[plaque]] stage may lack the particular storiform [[pattern]]
***CD163
* Many non-atypical [[mitotic]] figures may be present
***Factor XIIIa
* Non-[[Polarization|polarized]], thin [[collagen]]
***CD10
* Mild [[pleomorphism]] (not [[Significant figure|significant]])
**Negative staining for:
* Focal [[atypia]]
***Factor XIIIa (usually)
* May coexist with [[giant cell]] fibroblastoma
***Keratin
* Absent or [[rare]] [[histiocytes]]
***EMA
* Following [[Cell (biology)|cell]] types are absent:
***S100
**[[Histiocyte]]-like [[Cells (biology)|cells]]
***HMB45
**[[Foam cells]]
***Desmin
**[[Giant cells]]
***CD117<ref name="pmid17944726">{{cite journal| author=Labonte S, Hanna W, Bandarchi-Chamkhaleh B| title=A study of CD117 expression in dermatofibrosarcoma protuberans and cellular dermatofibroma. | journal=J Cutan Pathol | year= 2007 | volume= 34 | issue= 11 | pages= 857-60 | pmid=17944726 | doi=10.1111/j.1600-0560.2007.00731.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17944726  }} </ref>
** Other [[inflammatory cells]]
* Different '''variants''' include:
**[[Atrophic]] ([[Depress|depressed]] [[lesion]])
**[[Collagenous]] (with [[central]] thick [[collagen]] bundles)
**[[Granular cell]] ([[S100A1|S100]] negative)
** Myxoid
** Palisading
**[[Pigmented lesions|Pigmented]]
** Sclerosing

Revision as of 23:14, 15 August 2019


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]

  • Immunhistochemical staining of dermatofibrosarcoma protuberans shows:
    • Positive staining for:
      • CD34 (strong in 95%)
      • Vimentin
      • Focal actin
      • ApoD[1][2][3]
      • bcl2
      • NKI-C3[4]
      • CD99[5]
      • Nestin
      • Tenascin
      • CD163
      • Factor XIIIa
      • CD10
    • Negative staining for:
      • Factor XIIIa (usually)
      • Keratin
      • EMA
      • S100
      • HMB45
      • Desmin
      • CD117[6]
  1. ↑ West RB, Harvell J, Linn SC, Liu CL, Prapong W, Hernandez-Boussard T; et al. (2004). "Apo D in soft tissue tumors: a novel marker for dermatofibrosarcoma protuberans". Am J Surg Pathol. 28 (8): 1063–9. PMID 15252314.
  2. ↑ Lisovsky M, Hoang MP, Dresser KA, Kapur P, Bhawan J, Mahalingam M (2008). "Apolipoprotein D in CD34-positive and CD34-negative cutaneous neoplasms: a useful marker in differentiating superficial acral fibromyxoma from dermatofibrosarcoma protuberans". Mod Pathol. 21 (1): 31–8. doi:10.1038/modpathol.3800971. PMID 17885669.
  3. ↑ Bandarchi B, Ma L, Marginean C, Hafezi S, Zubovits J, Rasty G (2010). "D2-40, a novel immunohistochemical marker in differentiating dermatofibroma from dermatofibrosarcoma protuberans". Mod Pathol. 23 (3): 434–8. doi:10.1038/modpathol.2009.176. PMID 20062007.
  4. ↑ Ma CK, Zarbo RJ, Gown AM (1992). "Immunohistochemical characterization of atypical fibroxanthoma and dermatofibrosarcoma protuberans". Am J Clin Pathol. 97 (4): 478–83. doi:10.1093/ajcp/97.4.478. PMID 1553911.
  5. ↑ Diwan AH, Skelton HG, Horenstein MG, Kelly DR, Barrett TL, Bussian AH; et al. (2008). "Dermatofibrosarcoma protuberans and giant cell fibroblastoma exhibit CD99 positivity". J Cutan Pathol. 35 (7): 647–50. doi:10.1111/j.1600-0560.2007.00872.x. PMID 18201229.
  6. ↑ Labonte S, Hanna W, Bandarchi-Chamkhaleh B (2007). "A study of CD117 expression in dermatofibrosarcoma protuberans and cellular dermatofibroma". J Cutan Pathol. 34 (11): 857–60. doi:10.1111/j.1600-0560.2007.00731.x. PMID 17944726.
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