Extranodal NK-T-cell lymphoma pathophysiology: Difference between revisions
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* NK cells are CD3 and myloperoxidase negative on their surface.<ref name="HamKo2010">{{cite journal|last1=Ham|first1=Maria Francisca|last2=Ko|first2=Young-Hyeh|title=Natural killer cell neoplasm: biology and pathology|journal=International Journal of Hematology|volume=92|issue=5|year=2010|pages=681–689|issn=0925-5710|doi=10.1007/s12185-010-0738-y}}</ref> | * NK cells are CD3 and myloperoxidase negative on their surface.<ref name="HamKo2010">{{cite journal|last1=Ham|first1=Maria Francisca|last2=Ko|first2=Young-Hyeh|title=Natural killer cell neoplasm: biology and pathology|journal=International Journal of Hematology|volume=92|issue=5|year=2010|pages=681–689|issn=0925-5710|doi=10.1007/s12185-010-0738-y}}</ref> | ||
* NK cells have germline configuration of T-cell receptor and immunoglobulin genes. | * NK cells have germline configuration of T-cell receptor and immunoglobulin genes. | ||
*NK cells originate from a bipotent NK/T-progenitor cell so they have a lot in common with T cells. | |||
* | |||
===Immunotype=== | ===Immunotype=== | ||
Revision as of 01:09, 21 August 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2] Sowminya Arikapudi, M.B,B.S. [3]
Overview
Extra nodal NK-T-cell lymphoma, nasal type, can develop in either T cells or natural killer cells, but most often in the NK cells. Natural killer cells are a type of lymphocyte that is closely related to T cells and attack foreign cells. On gross pathology, angiocentric and angiodestructive pattern of growth with associated geographical necrosis and ulceration are characteristic findings of extranodal NK-T-cell lymphoma. On microscopic histopathological analysis, medium-sized tumor cells and polymorphic infiltrate of nonneoplastic inflammatory cells are characteristic findings of extranodal NK-T-cell lymphoma.[1][2]
Pathophysiology
Physiology
- NK cells are CD3 and myloperoxidase negative on their surface.[3]
- NK cells have germline configuration of T-cell receptor and immunoglobulin genes.
- NK cells originate from a bipotent NK/T-progenitor cell so they have a lot in common with T cells.
Immunotype
- The immunophenotype of NK lymphoma cells is classically positive for CD2, CD56, and cytoplasmic CD3 epsilon.
- They are negative for surface CD3. Unlike normal NK cells, the tumor cells are usually negative for CD7 and CD16.
- They express cytotoxic granule associated proteins granzyme B, T-cell restricted intracellular antigen (TIA-1), and perforin.
Gross Pathology
- On gross pathology, angiocentric and angiodestructive pattern of growth with associated geographical necrosis and ulceration are characteristic findings of extranodal NK-T-cell lymphoma.
- Coagulative necrosis and apoptotic bodies are frequently encountered.
Microscopic Pathology
- On microscopic histopathological analysis, medium sized tumor cells and polymorphic infiltrate of non-neoplastic inflammatory cells are characteristic findings of extranodal NK-T-cell lymphoma.
- The tumor cells are small to medium in size with occasional large and anaplastic forms.
- The lymphoma cells may be admixed with a polymorphic infiltrate of nonneoplastic inflammatory cells including small lymphocytes, plasma cells, histiocytes, and eosinophils.
References
- ↑ Extranodal Natural-Killer/T-Cell Lymphoma, Nasal Type. Hindawi Publishing Corporation. http://www.hindawi.com/journals/ah/2010/627401/. Accessed on February 18, 2016
- ↑ Extranodal NK/T-cell lymphoma, nasal type. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/extranodal-nk-t-cell-lymphoma-nasal-type/?region=on. Accessed on February 19, 2016
- ↑ Ham, Maria Francisca; Ko, Young-Hyeh (2010). "Natural killer cell neoplasm: biology and pathology". International Journal of Hematology. 92 (5): 681–689. doi:10.1007/s12185-010-0738-y. ISSN 0925-5710.