Extranodal NK-T-cell lymphoma classification: Difference between revisions
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=== Natural Killer cell neoplasms are classified by the world health organization (WHO) into: | === Natural Killer cell neoplasms are classified by the world health organization (WHO) into: === | ||
* NK/T-cell lymphoma, nasal type (NKTCL) | * NK/T-cell lymphoma, nasal type (NKTCL) <ref name="pmid23816348">{{cite journal| author=Lima M| title=Aggressive mature natural killer cell neoplasms: from epidemiology to diagnosis. | journal=Orphanet J Rare Dis | year= 2013 | volume= 8 | issue= | pages= 95 | pmid=23816348 | doi=10.1186/1750-1172-8-95 | pmc=3770456 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23816348 }} </ref> | ||
* Aggressive NK-cell leukemia (ANKCL) | * Aggressive NK-cell leukemia (ANKCL) | ||
* Chronic lymphoproliferative disorders of [[NK-cells|NK-cell]] <br /> | * Chronic lymphoproliferative disorders of [[NK-cells|NK-cell]] <br /> | ||
Revision as of 15:13, 16 September 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2] Sowminya Arikapudi, M.B,B.S. [3]
Overview
In contrast with B-cell lymphoma, classification of such a rare neoplasm has been controversial. Extranodal NK-T-cell lymphoma may be classified according to WHO into 2 subtypes: NK cell-derived neoplasms, namely, aggressive NK cell leukemia and extranodal NK-T-cell lymphoma, nasal type. Based on the organ involvement, extranodal NK-T-cell lymphoma may be classified into extranodal NK-T-cell lymphoma, nasal type, and extranodal NK-T-cell lymphoma, extra nasal type which contains two major subclass: Enteropathy type and subcutaneous panniculitis-like.
Classification
In contrast with B-cell lymphoma, classification of such a rare neoplasm has been controversial, since the cytologic features have not been very useful. Further, by many entities, T-cell and natural killer cell (NK) neoplasms do not share any similar immuno-phenotype. Because of such matter, clinical features became handier for classification and somehow even more important than the precise cell of origin.[1][2]
Since the majority of cytotoxic T-cell and NK cell lymphomas are located out of lymph nodes, the gene expressing cytotoxic molecules may predispose to apoptosis by tumor cells and by standard cells.
Three major categories of extranodal T/NK cell tumors include:[3]
- Extranodal NK/T-cell lymphoma, nasal type lymphoma
- Extranodal NK/T-cell lymphoma, enteropathy type lymphoma
- Extranodal NK/T-cell lymphoma, subcutaneous panniculitis-like
Extranodal NK-T-cell lymphoma may be classified according to WHO into 2 subtypes:
- NK cell-derived neoplasms, namely, aggressive NK cell leukemia
- Extranodal NK/T-cell lymphoma, nasal type
Based on the organ involvement, extranodal NK-T-cell lymphoma may be classified into:[4][1]
- Extranodal NK-T-cell lymphoma, nasal type
- Extranodal NK-T-cell lymphoma, extra nasal type
| Name | Description |
|---|---|
| Extranodal NK-T-cell lymphoma, nasal type |
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| Extranodal NK-T-cell lymphoma, extra nasal type |
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Natural Killer cell neoplasms are classified by the world health organization (WHO) into:
- NK/T-cell lymphoma, nasal type (NKTCL) [5]
- Aggressive NK-cell leukemia (ANKCL)
- Chronic lymphoproliferative disorders of NK-cell
References
- ↑ 1.0 1.1 Extranodal natural killer/T-cell lymphoma. BioMedCentral. http://jhoonline.biomedcentral.com/articles/10.1186/1756-8722-6-86. Accessed on February 19, 2016
- ↑ Extranodal Natural-Killer/T-Cell Lymphoma, Nasal Type. Hindawi Publishing Corporation. http://www.hindawi.com/journals/ah/2010/627401/. Accessed on February 18, 2016,
- ↑ Jaffe ES, Krenacs L, Raffeld M (2003). "Classification of cytotoxic T-cell and natural killer cell lymphomas". Semin Hematol. 40 (3): 175–84. PMID 12876666.
- ↑ Extranodal NK/T-cell lymphoma, nasal type. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/extranodal-nk-t-cell-lymphoma-nasal-type/?region=on. Accessed on February 18, 2016
- ↑ Lima M (2013). "Aggressive mature natural killer cell neoplasms: from epidemiology to diagnosis". Orphanet J Rare Dis. 8: 95. doi:10.1186/1750-1172-8-95. PMC 3770456. PMID 23816348.