Extranodal NK-T-cell lymphoma epidemiology and demographics: Difference between revisions
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=== Race === | === Race === | ||
* Natural Killer (NK) cell lymphoma is a rare disease. NK/T cell lymphoma, nasal type (NKTCL) and aggressive NK-cell leukemia (ANKCL) have a higher incidence in Asia, Central, and South America. | * Natural Killer (NK) cell lymphoma is a rare disease. NK/T cell lymphoma, nasal type (NKTCL) and aggressive NK-cell leukemia (ANKCL) have a higher incidence in Asia, Central, and South America.<ref name="AozasaTakakuwa2008">{{cite journal|last1=Aozasa|first1=Katsuyuki|last2=Takakuwa|first2=Tetsuya|last3=Hongyo|first3=Tadashi|last4=Yang|first4=Woo-Ick|title=Nasal NK/T-cell lymphoma: epidemiology and pathogenesis|journal=International Journal of Hematology|volume=87|issue=2|year=2008|pages=110–117|issn=0925-5710|doi=10.1007/s12185-008-0021-7}}</ref> | ||
* Nk cell lymphoma is usually associated with Epstein-Barr virus infection. | * Nk cell lymphoma is usually associated with Epstein-Barr virus infection.<ref name="pmid12824925">{{cite journal| author=Hoshida Y, Hongyo T, Jia X, He Y, Hasui K, Dong Z et al.| title=Analysis of p53, K-ras, c-kit, and beta-catenin gene mutations in sinonasal NK/T cell lymphoma in northeast district of China. | journal=Cancer Sci | year= 2003 | volume= 94 | issue= 3 | pages= 297-301 | pmid=12824925 | doi=10.1111/j.1349-7006.2003.tb01436.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12824925 }}</ref> | ||
=== Gender === | === Gender === | ||
* Extranodal NK/T-cell lymphoma shows male preponderance. | * Extranodal NK/T-cell lymphoma shows male preponderance.<ref name="Quintanilla-MartinezFranklin1999">{{cite journal|last1=Quintanilla-Martinez|first1=Leticia|last2=Franklin|first2=Janet L|last3=Guerrero|first3=Ivonne|last4=Krenacs|first4=Laszlo|last5=Naresh|first5=K.N|last6=Rama-Rao|first6=Clementina|last7=Bhatia|first7=Kishor|last8=Raffeld|first8=Mark|last9=Magrath|first9=Ian T|title=Histological and immunophenotypic profile of nasal NK/T cell lymphomas from Peru: High prevalence of p53 overexpression|journal=Human Pathology|volume=30|issue=7|year=1999|pages=849–855|issn=00468177|doi=10.1016/S0046-8177(99)90147-8}}</ref> | ||
=== Region === | === Region === | ||
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=== Age === | === Age === | ||
* The median age of onset is approximately 50 years and it is common in elderly. | * The median age of onset is approximately 50 years and it is common in elderly.<ref name="KoCho2004">{{cite journal|last1=Ko|first1=Y H|last2=Cho|first2=E-Y|last3=Kim|first3=J-E|last4=Lee|first4=S-S|last5=Huh|first5=J-R|last6=Chang|first6=H-K|last7=Yang|first7=W-I|last8=Kim|first8=C-W|last9=Kim|first9=S-W|last10=Ree|first10=H J|title=NK and NK-like T-cell lymphoma in extranasal sites: a comparative clinicopathological study according to site and EBV status|journal=Histopathology|volume=44|issue=5|year=2004|pages=480–489|issn=0309-0167|doi=10.1111/j.1365-2559.2004.01867.x}}</ref> | ||
* Extranodal NK/T-cell lymphoma is a rare disease in children and often it is associated with mosquito-bite hypersensetivity or other EBV-associated disease. | * Extranodal NK/T-cell lymphoma is a rare disease in children and often it is associated with mosquito-bite hypersensetivity or other EBV-associated disease. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2] Sowminya Arikapudi, M.B,B.S. [3]
Overview
Epidemiology and Demographics
Mortality rate
- NK cell lymphoma shows a poor prognosis because of rapid local progression and distant metastasis.
Race
- Natural Killer (NK) cell lymphoma is a rare disease. NK/T cell lymphoma, nasal type (NKTCL) and aggressive NK-cell leukemia (ANKCL) have a higher incidence in Asia, Central, and South America.[1]
- Nk cell lymphoma is usually associated with Epstein-Barr virus infection.[2]
Gender
- Extranodal NK/T-cell lymphoma shows male preponderance.[3]
Region
- NK T cell lymphoma, nasal type (NNKTL) consist 3000-10000 out of 100000 cases of non-Hodgkin lymphoma in Asia and South America and less than 1% in Western countries.
- It is estimated the incidence of NNKTL is higher in Asia by 10-folds.
Age
- The median age of onset is approximately 50 years and it is common in elderly.[4]
- Extranodal NK/T-cell lymphoma is a rare disease in children and often it is associated with mosquito-bite hypersensetivity or other EBV-associated disease.
References
- ↑ Aozasa, Katsuyuki; Takakuwa, Tetsuya; Hongyo, Tadashi; Yang, Woo-Ick (2008). "Nasal NK/T-cell lymphoma: epidemiology and pathogenesis". International Journal of Hematology. 87 (2): 110–117. doi:10.1007/s12185-008-0021-7. ISSN 0925-5710.
- ↑ Hoshida Y, Hongyo T, Jia X, He Y, Hasui K, Dong Z; et al. (2003). "Analysis of p53, K-ras, c-kit, and beta-catenin gene mutations in sinonasal NK/T cell lymphoma in northeast district of China". Cancer Sci. 94 (3): 297–301. doi:10.1111/j.1349-7006.2003.tb01436.x. PMID 12824925.
- ↑ Quintanilla-Martinez, Leticia; Franklin, Janet L; Guerrero, Ivonne; Krenacs, Laszlo; Naresh, K.N; Rama-Rao, Clementina; Bhatia, Kishor; Raffeld, Mark; Magrath, Ian T (1999). "Histological and immunophenotypic profile of nasal NK/T cell lymphomas from Peru: High prevalence of p53 overexpression". Human Pathology. 30 (7): 849–855. doi:10.1016/S0046-8177(99)90147-8. ISSN 0046-8177.
- ↑ Ko, Y H; Cho, E-Y; Kim, J-E; Lee, S-S; Huh, J-R; Chang, H-K; Yang, W-I; Kim, C-W; Kim, S-W; Ree, H J (2004). "NK and NK-like T-cell lymphoma in extranasal sites: a comparative clinicopathological study according to site and EBV status". Histopathology. 44 (5): 480–489. doi:10.1111/j.1365-2559.2004.01867.x. ISSN 0309-0167.