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In contrast with B-cell lymphoma, classification of such a rare [[neoplasm]] has been controversial. Extranodal NK-T-cell lymphoma may be classified according to [[WHO]] into 2 subtypes: [[Natural killer|NK]] cell-derived [[neoplasms]], namely, aggressive NK cell leukemia and extranodal NK-T-cell lymphoma, nasal type. Based on the organ involvement, extranodal NK-T-cell lymphoma may be classified into extranodal NK-T-cell lymphoma, nasal type, and extranodal NK-T-cell lymphoma, extra nasal type which contains two major subclass: [[Enteropathy]] type and [[subcutaneous]] panniculitis-like. | In contrast with B-cell lymphoma, classification of such a rare [[neoplasm]] has been controversial. Extranodal NK-T-cell lymphoma may be classified according to [[WHO]] into 2 subtypes: [[Natural killer|NK]] cell-derived [[neoplasms]], namely, aggressive NK cell leukemia and extranodal NK-T-cell lymphoma, nasal type. Based on the organ involvement, extranodal NK-T-cell lymphoma may be classified into extranodal NK-T-cell lymphoma, nasal type, and extranodal NK-T-cell lymphoma, extra nasal type which contains two major subclass: [[Enteropathy]] type and [[subcutaneous]] panniculitis-like. | ||
==Classification== | ==Classification== | ||
* In contrast with B-cell lymphoma, classification of such a rare neoplasm has been controversial, since the cytologic features have not been very useful. Further, by many entities, T-cell and natural killer cell (NK) neoplasms do not share any similar immuno-phenotype. Because of such matter, clinical features became handier for classification and somehow even more important than the precise cell of origin.<ref name="BioMedCentral"> Extranodal natural killer/T-cell lymphoma. BioMedCentral. http://jhoonline.biomedcentral.com/articles/10.1186/1756-8722-6-86. Accessed on February 19, 2016 </ref><ref name="Hindawi">Extranodal Natural-Killer/T-Cell Lymphoma, Nasal Type. Hindawi Publishing Corporation. http://www.hindawi.com/journals/ah/2010/627401/. Accessed on February 18, 2016, </ref> | |||
* Since the majority of [[Cytotoxic T-cells|cytotoxic T-cell]] and NK cell lymphomas are located out of [[lymph nodes]], the gene expressing cytotoxic molecules may predispose to [[apoptosis]] by [[tumor]] cells and by standard cells. | |||
* Extranodal NK/T-cell lymphoma, nasal type lymphoma | * Three major categories of extranodal T/NK cell tumors include:<ref name="pmid12876666">{{cite journal| author=Jaffe ES, Krenacs L, Raffeld M| title=Classification of cytotoxic T-cell and natural killer cell lymphomas. | journal=Semin Hematol | year= 2003 | volume= 40 | issue= 3 | pages= 175-84 | pmid=12876666 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12876666 }} </ref> | ||
* Extranodal NK/T-cell lymphoma, [[enteropathy]] type lymphoma | |||
* Extranodal NK/T-cell lymphoma, [[subcutaneous]] panniculitis-like | ** Extranodal NK/T-cell lymphoma, nasal type lymphoma | ||
** Extranodal NK/T-cell lymphoma, [[enteropathy]] type lymphoma | |||
** Extranodal NK/T-cell lymphoma, [[subcutaneous]] panniculitis-like | |||
Extranodal NK-T-cell lymphoma may be classified according to [[WHO]] into 2 subtypes: | Extranodal NK-T-cell lymphoma may be classified according to [[WHO]] into 2 subtypes: | ||
Revision as of 13:05, 30 September 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2] Sowminya Arikapudi, M.B,B.S. [3]
Overview
In contrast with B-cell lymphoma, classification of such a rare neoplasm has been controversial. Extranodal NK-T-cell lymphoma may be classified according to WHO into 2 subtypes: NK cell-derived neoplasms, namely, aggressive NK cell leukemia and extranodal NK-T-cell lymphoma, nasal type. Based on the organ involvement, extranodal NK-T-cell lymphoma may be classified into extranodal NK-T-cell lymphoma, nasal type, and extranodal NK-T-cell lymphoma, extra nasal type which contains two major subclass: Enteropathy type and subcutaneous panniculitis-like.
Classification
- In contrast with B-cell lymphoma, classification of such a rare neoplasm has been controversial, since the cytologic features have not been very useful. Further, by many entities, T-cell and natural killer cell (NK) neoplasms do not share any similar immuno-phenotype. Because of such matter, clinical features became handier for classification and somehow even more important than the precise cell of origin.[1][2]
- Since the majority of cytotoxic T-cell and NK cell lymphomas are located out of lymph nodes, the gene expressing cytotoxic molecules may predispose to apoptosis by tumor cells and by standard cells.
- Three major categories of extranodal T/NK cell tumors include:[3]
- Extranodal NK/T-cell lymphoma, nasal type lymphoma
- Extranodal NK/T-cell lymphoma, enteropathy type lymphoma
- Extranodal NK/T-cell lymphoma, subcutaneous panniculitis-like
Extranodal NK-T-cell lymphoma may be classified according to WHO into 2 subtypes:
- NK cell-derived neoplasms, namely, aggressive NK cell leukemia
- Extranodal NK/T-cell lymphoma, nasal type
Based on the organ involvement, extranodal NK-T-cell lymphoma may be classified into:[4][1]
- Extranodal NK-T-cell lymphoma, nasal type
- Extranodal NK-T-cell lymphoma, extra nasal type
| Name | Description |
|---|---|
| Extranodal NK-T-cell lymphoma, nasal type |
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| Extranodal NK-T-cell lymphoma, extra nasal type |
|
Natural Killer cell neoplasms are classified by the world health organization (WHO) into:
- NK/T-cell lymphoma, nasal type (NKTCL) [5]
- Aggressive NK-cell leukemia (ANKCL)
- Chronic lymphoproliferative disorders of NK-cell
References
- ↑ 1.0 1.1 Extranodal natural killer/T-cell lymphoma. BioMedCentral. http://jhoonline.biomedcentral.com/articles/10.1186/1756-8722-6-86. Accessed on February 19, 2016
- ↑ Extranodal Natural-Killer/T-Cell Lymphoma, Nasal Type. Hindawi Publishing Corporation. http://www.hindawi.com/journals/ah/2010/627401/. Accessed on February 18, 2016,
- ↑ Jaffe ES, Krenacs L, Raffeld M (2003). "Classification of cytotoxic T-cell and natural killer cell lymphomas". Semin Hematol. 40 (3): 175–84. PMID 12876666.
- ↑ Extranodal NK/T-cell lymphoma, nasal type. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/extranodal-nk-t-cell-lymphoma-nasal-type/?region=on. Accessed on February 18, 2016
- ↑ Lima M (2013). "Aggressive mature natural killer cell neoplasms: from epidemiology to diagnosis". Orphanet J Rare Dis. 8: 95. doi:10.1186/1750-1172-8-95. PMC 3770456. PMID 23816348.