Epithelioid sarcoma differential diagnosis: Difference between revisions
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!Location | !Location | ||
!Age group | !Age group | ||
! | !H/O of epithelial injury | ||
!CA125 | !CA125 | ||
! | !CK5/6 | ||
!GCDFP15, S100, actin | |||
!Necrosis | |||
!Calcification | |||
!Hemangiopericytomatous vessels | |||
|- | |- | ||
|Epitheloid Sarcoma | |Epitheloid Sarcoma | ||
| | | Positive | ||
| | | Positive | ||
|Sharply defined | |Sharply defined | ||
| | |Negative | ||
|Hand and wrist | |Hand and wrist | ||
| | |Under 40 years | ||
| | |No | ||
| | |Positive | ||
| | |Rare, Local | ||
|Negative | |||
|Extensive | |||
|Infrequent | |||
|Negative | |||
|- | |- | ||
|Palisaded Necrotic Granuloma | |Palisaded Necrotic Granuloma | ||
|Neagtive | |||
|Negative | |||
|Indistinct | |||
| | | | ||
|Uncommon | |||
| | | | ||
| | | | ||
| Line 54: | Line 66: | ||
|Squamous Carcinoma | |Squamous Carcinoma | ||
| | | | ||
|Negative | |||
| | | | ||
|Positive | |||
| | | | ||
|>40 | |||
|Positive | |||
|Negative in cutaneous SCC | |||
Positive everywhere | |||
|Extensive | |||
| | | | ||
| | | | ||
| | | | ||
| | | | ||
|- | |||
|Sweat Gland Carcinoma | |||
| | | | ||
|Negative | |||
| | | | ||
| | | | ||
| | | | ||
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| | | | ||
| | | | ||
|Positive | |||
| | | | ||
| | | | ||
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|Monophasic Synovial Sarcoma | |Monophasic Synovial Sarcoma | ||
| | | | ||
|Negative | |||
| | | | ||
| | | | ||
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| | | | ||
| | | | ||
|Negative | |||
| | | | ||
| | | | ||
| | |Focal | ||
|Frequent | |||
|Positive | |||
|- | |- | ||
|Melanoma | |Melanoma | ||
|Negative | |||
|Negative | |||
| | | | ||
| | | | ||
| Line 91: | Line 119: | ||
| | | | ||
| | | | ||
|Negative | |||
| | | | ||
|Positive | |||
| | | | ||
| | | | ||
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|- | |- | ||
|Epithelioid Hemangioendothelioma | |Epithelioid Hemangioendothelioma | ||
|Negative | |||
| | |||
| | |||
| | | | ||
|Uncommon on extremities | |||
| | | | ||
| | | | ||
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|- | |- | ||
|Sclerosing Epithelioid Fibrosarcoma | |Sclerosing Epithelioid Fibrosarcoma | ||
|Negative | |||
| | |||
|Cords of cells in hylainzed stroma | |||
| | |||
| | | | ||
| | | | ||
| Line 119: | Line 157: | ||
|- | |- | ||
|Ischemic Fasciitis | |Ischemic Fasciitis | ||
|Negative | |||
| | |||
|Basophilic or amphophilic | |||
| | |||
| | | | ||
| | | | ||
Revision as of 04:23, 21 September 2019
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Epithelioid sarcoma must be differentiated from synovial sarcoma, wart, ganglion cysts, rhabdomyosarcoma, and clear cell sarcoma.
Differentiating Epithelioid sarcoma from other Diseases
- Synovial sarcoma
- Ulcerating squamous cell carcinoma[1]
- Granulomatous diseases
- Traumatic wound
- Wart
- Ganglion cysts
- Giant cell tumors
- Rhabdomyosarcoma
- Clear cell sarcoma
- Vascular sarcoma
| Keratin | CD34 | Cytoplasm | In-sutu Kerataniztion | Location | Age group | H/O of epithelial injury | CA125 | CK5/6 | GCDFP15, S100, actin | Necrosis | Calcification | Hemangiopericytomatous vessels | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Epitheloid Sarcoma | Positive | Positive | Sharply defined | Negative | Hand and wrist | Under 40 years | No | Positive | Rare, Local | Negative | Extensive | Infrequent | Negative |
| Palisaded Necrotic Granuloma | Neagtive | Negative | Indistinct | Uncommon | |||||||||
| Squamous Carcinoma | Negative | Positive | >40 | Positive | Negative in cutaneous SCC
Positive everywhere |
Extensive | |||||||
| Sweat Gland Carcinoma | Negative | Positive | |||||||||||
| Monophasic Synovial Sarcoma | Negative | Negative | Focal | Frequent | Positive | ||||||||
| Melanoma | Negative | Negative | Negative | Positive | |||||||||
| Epithelioid Hemangioendothelioma | Negative | Uncommon on extremities | |||||||||||
| Sclerosing Epithelioid Fibrosarcoma | Negative | Cords of cells in hylainzed stroma | |||||||||||
| Ischemic Fasciitis | Negative | Basophilic or amphophilic |
References
- ↑ Epithelioid sarcoma. Sarcomahelp (2016). http://sarcomahelp.org/epithelioid-sarcoma.html Accessed on February 8, 2016