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== Overview ==
== Overview ==
Common findings in amyloidosis include waxy thickening, [[easy bruising]], [[purpura]], macroglossia, [[parotid gland]] and [[submandibular gland]] enlargement, [[edema]], [[numbness]] and [[paresthesia]].
Common findings in familial amyloidosis include waxy thickening, [[easy bruising]], [[purpura]], macroglossia, [[parotid gland]] and [[submandibular gland]] enlargement, [[edema]], [[numbness]] and [[paresthesia]].


==Physical Examination==
==Physical Examination==
[[Physical examination]] of patients withamyloidosis is usually remarkable for waxy thickening, [[easy bruising]], [[purpura]], [[macroglossia]], [[parotid gland]] and [[submandibular gland]] enlargement, [[edema]], [[numbness]] and [[paresthesia]].<ref name="pmid267192344">{{cite journal |vauthors=Wechalekar AD, Gillmore JD, Hawkins PN |title=Systemic amyloidosis |journal=Lancet |volume=387 |issue=10038 |pages=2641–2654 |date=June 2016 |pmid=26719234 |doi=10.1016/S0140-6736(15)01274-X |url=}}</ref><ref name="pmid14660909">{{cite journal |vauthors=Pribitkin E, Friedman O, O'Hara B, Cunnane MF, Levi D, Rosen M, Keane WM, Sataloff RT |title=Amyloidosis of the upper aerodigestive tract |journal=Laryngoscope |volume=113 |issue=12 |pages=2095–101 |date=December 2003 |pmid=14660909 |doi=10.1097/00005537-200312000-00007 |url=}}</ref><ref name="pmid23239211">{{cite journal |vauthors=Shin SC, Robinson-Papp J |title=Amyloid neuropathies |journal=Mt. Sinai J. Med. |volume=79 |issue=6 |pages=733–48 |date=2012 |pmid=23239211 |pmc=3531896 |doi=10.1002/msj.21352 |url=}}</ref><br />
[[Physical examination]] of patients with familial amyloidosis is usually remarkable for waxy thickening, [[easy bruising]], [[purpura]], [[macroglossia]], [[parotid gland]] and [[submandibular gland]] enlargement, [[edema]], [[numbness]] and [[paresthesia]].<ref name="pmid267192344">{{cite journal |vauthors=Wechalekar AD, Gillmore JD, Hawkins PN |title=Systemic amyloidosis |journal=Lancet |volume=387 |issue=10038 |pages=2641–2654 |date=June 2016 |pmid=26719234 |doi=10.1016/S0140-6736(15)01274-X |url=}}</ref><ref name="pmid14660909">{{cite journal |vauthors=Pribitkin E, Friedman O, O'Hara B, Cunnane MF, Levi D, Rosen M, Keane WM, Sataloff RT |title=Amyloidosis of the upper aerodigestive tract |journal=Laryngoscope |volume=113 |issue=12 |pages=2095–101 |date=December 2003 |pmid=14660909 |doi=10.1097/00005537-200312000-00007 |url=}}</ref><ref name="pmid23239211">{{cite journal |vauthors=Shin SC, Robinson-Papp J |title=Amyloid neuropathies |journal=Mt. Sinai J. Med. |volume=79 |issue=6 |pages=733–48 |date=2012 |pmid=23239211 |pmc=3531896 |doi=10.1002/msj.21352 |url=}}</ref><br />
===Appearance of the Patient===
===Appearance of the Patient===
*Patients with amyloidosis usually appear normal.
*Patients with familial amyloidosis usually appear normal.
===Vital signs===
===Vital signs===
* [[Hypertension]]
* [[Hypertension]]
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===Skin===
===Skin===
*Waxy thickening
*Waxy thickening
*Easy bruising (ecchymoses)
*Easy [[bruising]] (ecchymoses)
*Subcutaneous [[nodules]] or [[plaques]]
*Subcutaneous [[nodules]] or [[plaques]]
*[[Purpura]]
*[[Purpura]]
* [[Petechiae]]  
* [[Petechiae]]  
* Brittle nails
*[[Edema]]
*[[Edema]]
*Diffuse or patchy [[alopecia]]
*Diffuse or patchy [[alopecia]]
*Nail dystrophy  
*Nail dystrophy  
*Brittle nails
*[[Brittle nails]]
 
===Nodular Amyloidosis===
===Nodular Amyloidosis===
<gallery widths="130px">
<gallery widths="130px">
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===Neck===
===Neck===
* Neck examination of patients with amyloidosis is usually normal.
* Neck examination of patients with familial amyloidosis is usually normal.


===Lungs===
===Lungs===
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===Back===
===Back===
* Back examination of patients with amyloidosis is usually normal.
* Back examination of patients with familial amyloidosis is usually normal.


===Genitourinary===
===Genitourinary===
*[[Genitourinary]] examination of patients with amyloidosis is usually normal.
*[[Genitourinary]] examination of patients with familial amyloidosis is usually normal.


===Neuromuscular===
===Neuromuscular===

Revision as of 17:23, 30 October 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]

Overview

Common findings in familial amyloidosis include waxy thickening, easy bruising, purpura, macroglossia, parotid gland and submandibular gland enlargement, edema, numbness and paresthesia.

Physical Examination

Physical examination of patients with familial amyloidosis is usually remarkable for waxy thickening, easy bruising, purpura, macroglossia, parotid gland and submandibular gland enlargement, edema, numbness and paresthesia.[1][2][3]

Appearance of the Patient

  • Patients with familial amyloidosis usually appear normal.

Vital signs

Skin

Nodular Amyloidosis

HEENT


Neck

  • Neck examination of patients with familial amyloidosis is usually normal.

Lungs

Heart

Abdomen

Back

  • Back examination of patients with familial amyloidosis is usually normal.

Genitourinary

  • Genitourinary examination of patients with familial amyloidosis is usually normal.

Neuromuscular

Extremities

Macular Amyloidosis

References

  1. ↑ Wechalekar AD, Gillmore JD, Hawkins PN (June 2016). "Systemic amyloidosis". Lancet. 387 (10038): 2641–2654. doi:10.1016/S0140-6736(15)01274-X. PMID 26719234.
  2. ↑ Pribitkin E, Friedman O, O'Hara B, Cunnane MF, Levi D, Rosen M, Keane WM, Sataloff RT (December 2003). "Amyloidosis of the upper aerodigestive tract". Laryngoscope. 113 (12): 2095–101. doi:10.1097/00005537-200312000-00007. PMID 14660909.
  3. ↑ Shin SC, Robinson-Papp J (2012). "Amyloid neuropathies". Mt. Sinai J. Med. 79 (6): 733–48. doi:10.1002/msj.21352. PMC 3531896. PMID 23239211.

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