Coronavirus Diagnostic Criteria: Difference between revisions
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==Diagnostic Criteria== | ==Diagnostic Criteria== | ||
=== 2019-nCoV === | |||
Patients in the United States who meet the following criteria should be evaluated as in association with the outbreak of 2019-nCoV in Wuhan City, China. | Patients in the United States who meet the following criteria should be evaluated as in association with the outbreak of 2019-nCoV in Wuhan City, China. | ||
{| class="wikitable" | {| class="wikitable" | ||
| Line 12: | Line 14: | ||
!Epidemiologic Risk | !Epidemiologic Risk | ||
|- | |- | ||
| | |Fever and symptoms of lower respiratory illness (e.g., cough, difficulty breathing) | ||
|and | |and | ||
|In the last 14 days before symptom onset, a history of travel from Wuhan City, China. | |In the last 14 days before symptom onset, a history of travel from Wuhan City, China. | ||
| Line 19: | Line 21: | ||
In the last 14 days before symptom onset, close contact2 with a person who is under investigation for 2019-nCoV while that person was ill. | In the last 14 days before symptom onset, close contact2 with a person who is under investigation for 2019-nCoV while that person was ill. | ||
|- | |- | ||
| | |Fever or symptoms of lower respiratory illness (e.g., cough, difficulty breathing) | ||
|and | |and | ||
|In the last 14 days, close contact2 with an ill laboratory-confirmed 2019-nCoV patient. | |In the last 14 days, close contact2 with an ill laboratory-confirmed 2019-nCoV patient. | ||
|} | |} | ||
=== MERS-CoV === | |||
Criteria for detection of MERS-CoV RNA: a positive result for at least one of the following: | |||
* Positivity for at least two MERS-CoV-specific gene targets (''upE'', ''ORF1a'', ''ORF1b'', ''N'') by real-time RT-PCR (recommended) | |||
* Positivity on RT-PCR result for at least one MERS-CoV-specific gene target [''ORF1b'' (''RdRp''), ''N''], AND confirmation by base sequence analysis of the PCR product | |||
* Diagnosis by serological tests: a) Seroconversion using two serum specimens collected at an interval of at least 14 days b) The screening test with ELISA or IFA, and the confirmatory neutralization test <br /> | |||
==References== | ==References== | ||
Revision as of 15:55, 3 February 2020
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Coronavirus Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Coronavirus Diagnostic Criteria On the Web |
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American Roentgen Ray Society Images of Coronavirus Diagnostic Criteria |
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Risk calculators and risk factors for Coronavirus Diagnostic Criteria |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Diagnostic Criteria
2019-nCoV
Patients in the United States who meet the following criteria should be evaluated as in association with the outbreak of 2019-nCoV in Wuhan City, China.
| Clinical Features | & | Epidemiologic Risk |
|---|---|---|
| Fever and symptoms of lower respiratory illness (e.g., cough, difficulty breathing) | and | In the last 14 days before symptom onset, a history of travel from Wuhan City, China.
– or – In the last 14 days before symptom onset, close contact2 with a person who is under investigation for 2019-nCoV while that person was ill. |
| Fever or symptoms of lower respiratory illness (e.g., cough, difficulty breathing) | and | In the last 14 days, close contact2 with an ill laboratory-confirmed 2019-nCoV patient. |
MERS-CoV
Criteria for detection of MERS-CoV RNA: a positive result for at least one of the following:
- Positivity for at least two MERS-CoV-specific gene targets (upE, ORF1a, ORF1b, N) by real-time RT-PCR (recommended)
- Positivity on RT-PCR result for at least one MERS-CoV-specific gene target [ORF1b (RdRp), N], AND confirmation by base sequence analysis of the PCR product
- Diagnosis by serological tests: a) Seroconversion using two serum specimens collected at an interval of at least 14 days b) The screening test with ELISA or IFA, and the confirmatory neutralization test