Rhabdomyolysis overview: Difference between revisions
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==Causes== | ==Causes== | ||
The causes can be divided into 3 categories:<ref name="pmidPMID: 7078398">{{cite journal| author=Gabow PA, Kaehny WD, Kelleher SP| title=The spectrum of rhabdomyolysis. | journal=Medicine (Baltimore) | year= 1982 | volume= 61 | issue= 3 | pages= 141-52 | pmid=PMID: 7078398 | doi=10.1097/00005792-198205000-00002 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7078398 }} </ref> | The causes can be divided into 3 categories:<ref name="pmidPMID: 7078398">{{cite journal| author=Gabow PA, Kaehny WD, Kelleher SP| title=The spectrum of rhabdomyolysis. | journal=Medicine (Baltimore) | year= 1982 | volume= 61 | issue= 3 | pages= 141-52 | pmid=PMID: 7078398 | doi=10.1097/00005792-198205000-00002 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7078398 }} </ref><ref name="pmidPMID: 16267412">{{cite journal| author=Melli G, Chaudhry V, Cornblath DR| title=Rhabdomyolysis: an evaluation of 475 hospitalized patients. | journal=Medicine (Baltimore) | year= 2005 | volume= 84 | issue= 6 | pages= 377-85 | pmid=PMID: 16267412 | doi=10.1097/01.md.0000188565.48918.41 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16267412 }} </ref> | ||
* Traumatic or muscle compression. | * Traumatic or muscle compression. | ||
* Nontraumatic exertional. | * Nontraumatic exertional. | ||
Revision as of 15:40, 9 June 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ayesha Javid, MBBS[2]
Overview
Rhabdomyolysis is the rapid breakdown of skeletal muscle tissue due to traumatic injury, either mechanical, physical, or chemical. The principal result is a large release of the creatine kinase (CK) enzymes and other cell byproducts into the blood system and acute renal failure due to accumulation of muscle breakdown products, several of which are injurious to the kidney. Treatment is with intravenous fluids, and dialysis if necessary.
Causes
The causes can be divided into 3 categories:[1][2]
- Traumatic or muscle compression.
- Nontraumatic exertional.
- Nontraumatic non-exertional.
Diagnosis
Physical Examination
A physical usually reveals no abnormalities, but there may be tenderness, weakness, or atrophy.
Electrocardiogram
The EKG can show non specific ST T wave changes and T wave inversions. Despite the very high level of CK, the criteria for MI requires a 5% MB index (may vary by assay and gender).
References
- ↑ Gabow PA, Kaehny WD, Kelleher SP (1982). "The spectrum of rhabdomyolysis". Medicine (Baltimore). 61 (3): 141–52. doi:10.1097/00005792-198205000-00002. PMID 7078398 PMID: 7078398 Check
|pmid=value (help). - ↑ Melli G, Chaudhry V, Cornblath DR (2005). "Rhabdomyolysis: an evaluation of 475 hospitalized patients". Medicine (Baltimore). 84 (6): 377–85. doi:10.1097/01.md.0000188565.48918.41. PMID 16267412 PMID: 16267412 Check
|pmid=value (help).