Tuberous sclerosis surgery: Difference between revisions

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==Overview==
==Overview==

Latest revision as of 17:58, 23 June 2020

Tuberous sclerosis Microchapters

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Patient Information

Overview

Historical Perspective

Pathophysiology

Differentiating Tuberous sclerosis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

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History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

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Echocardiography or Ultrasound

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Treatment

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Surgery

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Cost-Effectiveness of Therapy

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Case #1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: José Eduardo Riceto Loyola Junior, M.D.[2]

Overview

Surgical options have been historically the only way to treat the TSC-associated complications, but with the introduction of the mTOR inhibitors they have been left for more severe or refractory complications.

Surgical Treatment

Epilepsy

Angiomyolipoma

  • Treatment is done in a pre-emptive manner to prevent bleeding, reduce tumor size or slow its growth. Percutaneous embolization (which may present with postembolization syndrome) and nephron-sparing surgical resection are possible treatments.[1]

Subependymal Giant Cell Astrocytoma

  • Surgical resection is the most performed treatment, but may complicate with incomplete resection, hemorrhage, infection and cerebrospinal fluid obstruction.[1]

Skin Lesions

For TSC-associated skin lesions, the following surgical treatments may be performed:

  • Ablation with pulse laser dye or CO2;
  • Surgery

References

  1. 1.0 1.1 1.2 Henske, Elizabeth P., et al. "Tuberous sclerosis complex." Nature reviews Disease primers 2.1 (2016): 1-18.