Bronchogenic cyst overview: Difference between revisions

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Differentiating bronchogenic [[cyst]] from [[Lung abscess physical examination|lung abcess]], [[Mediastinal mass differential diagnosis|thymic cyst]], and [[Mediastinal mass differential diagnosis|esophageal duplication cysts]].
Differentiating bronchogenic [[cyst]] from [[Lung abscess physical examination|lung abcess]], [[Mediastinal mass differential diagnosis|thymic cyst]], and [[Mediastinal mass differential diagnosis|esophageal duplication cysts]].
==Bronchogenic cyst epidemiology and demographics|Epidemiology and Demographics==
==Bronchogenic cyst epidemiology and demographics|Epidemiology and Demographics==
There is no racial predilection to bronchogenic [[cyst]]. Bronchogenic [[cyst]] is slightly more [[prevalence|prevalent]] in men and often remain undetected until the third or fourth decade of life.
There is no racial predilection to bronchogenic [[cyst]]. Bronchogenic [[cyst]] is slightly more [[prevalence|prevalent]] in men and often remain undetected till the third or fourth decade of life.<ref name="pmid10554866">{{cite journal| author=Lardinois D, Gugger M, Ris HB| title=Bronchogenic cyst of the left lower lobe associated with severe hemoptysis. | journal=Eur J Cardiothorac Surg | year= 1999 | volume= 16 | issue= 3 | pages= 382-3 | pmid=10554866 | doi=10.1016/s1010-7940(99)00226-2 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10554866  }} </ref><ref name="pmid8902460">{{cite journal| author=Aktoğu S, Yuncu G, Halilçolar H, Ermete S, Buduneli T| title=Bronchogenic cysts: clinicopathological presentation and treatment. | journal=Eur Respir J | year= 1996 | volume= 9 | issue= 10 | pages= 2017-21 | pmid=8902460 | doi=10.1183/09031936.96.09102017 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8902460  }} </ref>
 
==Risk factors==
==Risk factors==
There are no established risk factors for bronchogenic [[cyst]].
There are no established risk factors for bronchogenic [[cyst]].
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[[Prognosis]] is generally good,<ref name="pmid19015445">{{cite journal| author=Teissier N, Elmaleh-Bergès M, Ferkdadji L, François M, Van den Abbeele T| title=Cervical bronchogenic cysts: usual and unusual clinical presentations. | journal=Arch Otolaryngol Head Neck Surg | year= 2008 | volume= 134 | issue= 11 | pages= 1165-9 | pmid=19015445 | doi=10.1001/archotol.134.11.1165 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19015445  }} </ref> a [[Morbidity & Mortality]] rate of 20% has been recorded in older patients treated for bronchogenic [[cyst]].<ref name="pmid21420068">{{cite journal| author=Makhija Z, Moir CR, Allen MS, Cassivi SD, Deschamps C, Nichols FC | display-authors=etal| title=Surgical management of congenital cystic lung malformations in older patients. | journal=Ann Thorac Surg | year= 2011 | volume= 91 | issue= 5 | pages= 1568-73; discussion 1573 | pmid=21420068 | doi=10.1016/j.athoracsur.2011.01.080 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21420068  }} </ref>
[[Prognosis]] is generally good,<ref name="pmid19015445">{{cite journal| author=Teissier N, Elmaleh-Bergès M, Ferkdadji L, François M, Van den Abbeele T| title=Cervical bronchogenic cysts: usual and unusual clinical presentations. | journal=Arch Otolaryngol Head Neck Surg | year= 2008 | volume= 134 | issue= 11 | pages= 1165-9 | pmid=19015445 | doi=10.1001/archotol.134.11.1165 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19015445  }} </ref> a [[Morbidity & Mortality]] rate of 20% has been recorded in older patients treated for bronchogenic [[cyst]].<ref name="pmid21420068">{{cite journal| author=Makhija Z, Moir CR, Allen MS, Cassivi SD, Deschamps C, Nichols FC | display-authors=etal| title=Surgical management of congenital cystic lung malformations in older patients. | journal=Ann Thorac Surg | year= 2011 | volume= 91 | issue= 5 | pages= 1568-73; discussion 1573 | pmid=21420068 | doi=10.1016/j.athoracsur.2011.01.080 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21420068  }} </ref>
== Diagnostic Study of Choice ==
== Diagnostic Study of Choice ==
[[Excision]] and [[H&E stain|Hematoxylin and Eosin staining]].
[[Excision]] and [[H&E stain|Hematoxylin and Eosin staining]]<ref name="pmid17874358">{{cite journal| author=Chuang KH, Huang TW, Cheng YL, Chen JC, Tzao C, Chang H | display-authors=etal| title=Esophageal bronchogenic cyst: a rare entity. | journal=Z Gastroenterol | year= 2007 | volume= 45 | issue= 9 | pages= 958-60 | pmid=17874358 | doi=10.1055/s-2007-963069 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17874358  }} </ref>
===== Diagnostic results =====
===== Diagnostic results =====
Cillated [[columar epithelia]] cells is definitive for broncogenic [[cyst]].<ref name="pmid17874358">{{cite journal| author=Chuang KH, Huang TW, Cheng YL, Chen JC, Tzao C, Chang H | display-authors=etal| title=Esophageal bronchogenic cyst: a rare entity. | journal=Z Gastroenterol | year= 2007 | volume= 45 | issue= 9 | pages= 958-60 | pmid=17874358 | doi=10.1055/s-2007-963069 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17874358  }} </ref><ref name="pmid26986156">{{cite journal| author=Han C, Lin R, Yu J, Zhang Q, Zhang Y, Liu J | display-authors=etal| title=A Case Report of Esophageal Bronchogenic Cyst and Review of the Literature With an Emphasis on Endoscopic Ultrasonography Appearance. | journal=Medicine (Baltimore) | year= 2016 | volume= 95 | issue= 11 | pages= e3111 | pmid=26986156 | doi=10.1097/MD.0000000000003111 | pmc=4839937 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26986156  }} </ref><ref name="pmid31462259">{{cite journal| author=Yang X, Zong Y, Zhao HY, Wu YD, Ji M| title=Complete excision of esophageal bronchogenic cyst by endoscopic submucosal tunnel dissection: a case presentation. | journal=BMC Gastroenterol | year= 2019 | volume= 19 | issue= 1 | pages= 155 | pmid=31462259 | doi=10.1186/s12876-019-1072-3 | pmc=6714396 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=31462259  }} </ref><ref name="pmid8902460">{{cite journal| author=Aktoğu S, Yuncu G, Halilçolar H, Ermete S, Buduneli T| title=Bronchogenic cysts: clinicopathological presentation and treatment. | journal=Eur Respir J | year= 1996 | volume= 9 | issue= 10 | pages= 2017-21 | pmid=8902460 | doi=10.1183/09031936.96.09102017 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8902460  }} </ref>
Cillated [[columar epithelia]] cells is definitive for broncogenic [[cyst]].<ref name="pmid17874358">{{cite journal| author=Chuang KH, Huang TW, Cheng YL, Chen JC, Tzao C, Chang H | display-authors=etal| title=Esophageal bronchogenic cyst: a rare entity. | journal=Z Gastroenterol | year= 2007 | volume= 45 | issue= 9 | pages= 958-60 | pmid=17874358 | doi=10.1055/s-2007-963069 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17874358  }} </ref><ref name="pmid26986156">{{cite journal| author=Han C, Lin R, Yu J, Zhang Q, Zhang Y, Liu J | display-authors=etal| title=A Case Report of Esophageal Bronchogenic Cyst and Review of the Literature With an Emphasis on Endoscopic Ultrasonography Appearance. | journal=Medicine (Baltimore) | year= 2016 | volume= 95 | issue= 11 | pages= e3111 | pmid=26986156 | doi=10.1097/MD.0000000000003111 | pmc=4839937 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26986156  }} </ref><ref name="pmid31462259">{{cite journal| author=Yang X, Zong Y, Zhao HY, Wu YD, Ji M| title=Complete excision of esophageal bronchogenic cyst by endoscopic submucosal tunnel dissection: a case presentation. | journal=BMC Gastroenterol | year= 2019 | volume= 19 | issue= 1 | pages= 155 | pmid=31462259 | doi=10.1186/s12876-019-1072-3 | pmc=6714396 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=31462259  }} </ref><ref name="pmid8902460">{{cite journal| author=Aktoğu S, Yuncu G, Halilçolar H, Ermete S, Buduneli T| title=Bronchogenic cysts: clinicopathological presentation and treatment. | journal=Eur Respir J | year= 1996 | volume= 9 | issue= 10 | pages= 2017-21 | pmid=8902460 | doi=10.1183/09031936.96.09102017 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8902460  }} </ref>
==== Diagnostic criteria ====
==== Diagnostic criteria ====
Cystic mass producing compressive symptoms.
Cystic mass producing compressive symptoms.  
 
==History and symptoms==
==History and symptoms==
The majority of patients with bronchogenic [[cyst]]  are [[asymptomatic]] and are diagnosed during investigations for other pathologies.<ref name="pmid17859095">{{cite journal| author=Maier HC| title=Bronchiogenic Cysts of the Mediastinum. | journal=Ann Surg | year= 1948 | volume= 127 | issue= 3 | pages= 476-502 | pmid=17859095 | doi=10.1097/00000658-194803000-00010 | pmc=1513836 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17859095  }} </ref><ref name="pmid31462259">{{cite journal| author=Yang X, Zong Y, Zhao HY, Wu YD, Ji M| title=Complete excision of esophageal bronchogenic cyst by endoscopic submucosal tunnel dissection: a case presentation. | journal=BMC Gastroenterol | year= 2019 | volume= 19 | issue= 1 | pages= 155 | pmid=31462259 | doi=10.1186/s12876-019-1072-3 | pmc=6714396 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=31462259  }} </ref><ref name="pmid480084">{{cite journal| author=Ramenofsky ML, Leape LL, McCauley RG| title=Bronchogenic cyst. | journal=J Pediatr Surg | year= 1979 | volume= 14 | issue= 3 | pages= 219-24 | pmid=480084 | doi=10.1016/s0022-3468(79)80474-1 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=480084  }} </ref>
The majority of patients with bronchogenic [[cyst]]  are [[asymptomatic]] and are diagnosed during investigations for other pathologies.<ref name="pmid17859095">{{cite journal| author=Maier HC| title=Bronchiogenic Cysts of the Mediastinum. | journal=Ann Surg | year= 1948 | volume= 127 | issue= 3 | pages= 476-502 | pmid=17859095 | doi=10.1097/00000658-194803000-00010 | pmc=1513836 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17859095  }} </ref><ref name="pmid31462259">{{cite journal| author=Yang X, Zong Y, Zhao HY, Wu YD, Ji M| title=Complete excision of esophageal bronchogenic cyst by endoscopic submucosal tunnel dissection: a case presentation. | journal=BMC Gastroenterol | year= 2019 | volume= 19 | issue= 1 | pages= 155 | pmid=31462259 | doi=10.1186/s12876-019-1072-3 | pmc=6714396 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=31462259  }} </ref><ref name="pmid480084">{{cite journal| author=Ramenofsky ML, Leape LL, McCauley RG| title=Bronchogenic cyst. | journal=J Pediatr Surg | year= 1979 | volume= 14 | issue= 3 | pages= 219-24 | pmid=480084 | doi=10.1016/s0022-3468(79)80474-1 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=480084  }} </ref>
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Physical examination of patients with bronchogenic [[cyst]] is usually normal. On rare occasions, the following signs can be seen
Physical examination of patients with bronchogenic [[cyst]] is usually normal. On rare occasions, the following signs can be seen
*[[Cough]]
*[[Cough]]<ref name="pmid26986156">{{cite journal| author=Han C, Lin R, Yu J, Zhang Q, Zhang Y, Liu J | display-authors=etal| title=A Case Report of Esophageal Bronchogenic Cyst and Review of the Literature With an Emphasis on Endoscopic Ultrasonography Appearance. | journal=Medicine (Baltimore) | year= 2016 | volume= 95 | issue= 11 | pages= e3111 | pmid=26986156 | doi=10.1097/MD.0000000000003111 | pmc=4839937 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26986156  }} </ref> <ref name="pmid12809250">{{cite journal| author=Sarper A, Ayten A, Golbasi I, Demircan A, Isin E| title=Bronchogenic cyst. | journal=Tex Heart Inst J | year= 2003 | volume= 30 | issue= 2 | pages= 105-8 | pmid=12809250 | doi= | pmc=161894 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12809250  }} </ref><ref name="pmid30846076">{{cite journal| author=Ayub II, Balakrishnan H, Arshad AM, Manimaran N, Thangaswamy D, Chockalingam C| title=A 44-Year-Old Man With Nonproductive Cough and Sensation of Heaviness Over the Upper Chest. | journal=Chest | year= 2019 | volume= 155 | issue= 3 | pages= e65-e68 | pmid=30846076 | doi=10.1016/j.chest.2018.09.035 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30846076  }} </ref>
*[[Wheeze|wheezing]]
*[[Wheeze|wheezing]]<ref name="pmid17859095">{{cite journal| author=Maier HC| title=Bronchiogenic Cysts of the Mediastinum. | journal=Ann Surg | year= 1948 | volume= 127 | issue= 3 | pages= 476-502 | pmid=17859095 | doi=10.1097/00000658-194803000-00010 | pmc=1513836 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17859095  }} </ref> 
*[[Stridor]]
*[[Stridor]]<ref name="pmid27986331">{{cite journal| author=Hsu CG, Heller M, Johnston GS, Felberbaum M| title=An Unusual Cause of Airway Compromise in the Emergency Department: Mediastinal Bronchogenic Cyst. | journal=J Emerg Med | year= 2017 | volume= 52 | issue= 3 | pages= e91-e93 | pmid=27986331 | doi=10.1016/j.jemermed.2016.11.004 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27986331  }} </ref>
*[[Hemoptysis]]
*[[Hemoptysis]]<ref name="pmid12809250">{{cite journal| author=Sarper A, Ayten A, Golbasi I, Demircan A, Isin E| title=Bronchogenic cyst. | journal=Tex Heart Inst J | year= 2003 | volume= 30 | issue= 2 | pages= 105-8 | pmid=12809250 | doi= | pmc=161894 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12809250  }} </ref>
*[[Dyspnea]]
*[[Dyspnea]]<ref name="pmid17874358">{{cite journal| author=Chuang KH, Huang TW, Cheng YL, Chen JC, Tzao C, Chang H | display-authors=etal| title=Esophageal bronchogenic cyst: a rare entity. | journal=Z Gastroenterol | year= 2007 | volume= 45 | issue= 9 | pages= 958-60 | pmid=17874358 | doi=10.1055/s-2007-963069 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17874358  }} </ref><ref name="pmid27986331">{{cite journal| author=Hsu CG, Heller M, Johnston GS, Felberbaum M| title=An Unusual Cause of Airway Compromise in the Emergency Department: Mediastinal Bronchogenic Cyst. | journal=J Emerg Med | year= 2017 | volume= 52 | issue= 3 | pages= e91-e93 | pmid=27986331 | doi=10.1016/j.jemermed.2016.11.004 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27986331  }} </ref>
*[[Tracheal deviation]]
*[[Tracheal deviation]]<ref name="pmid26112048">{{cite journal| author=Thaller P, Blanchet C, Badr M, Mesnage R, Leboucq N, Mondain M | display-authors=etal| title=Neonatal respiratory distress syndrome revealing a cervical bronchogenic cyst: a case report. | journal=BMC Pediatr | year= 2015 | volume= 15 | issue=  | pages= 72 | pmid=26112048 | doi=10.1186/s12887-015-0363-2 | pmc=4491209 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26112048  }} </ref>
*[[ascites|Fluid-thrill]]
*[[ascites|Fluid-thrill]]<ref name="pmid29389833">{{cite journal| author=Nachef Z, Harris K, Dhillon SS| title=Bronchogenic Cyst: Fluid-thrill Sign on Endobronchial Ultrasound. | journal=J Bronchology Interv Pulmonol | year= 2018 | volume= 25 | issue= 3 | pages= 224-227 | pmid=29389833 | doi=10.1097/LBR.0000000000000473 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29389833  }} </ref>
*[[Anorexia]] and/or [[weight loss]]
*[[Anorexia]] and/or [[weight loss]]<ref name="pmid8902460">{{cite journal| author=Aktoğu S, Yuncu G, Halilçolar H, Ermete S, Buduneli T| title=Bronchogenic cysts: clinicopathological presentation and treatment. | journal=Eur Respir J | year= 1996 | volume= 9 | issue= 10 | pages= 2017-21 | pmid=8902460 | doi=10.1183/09031936.96.09102017 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8902460  }} </ref>
*[[Fever]]
*[[Fever]]<ref name="pmid12809250">{{cite journal| author=Sarper A, Ayten A, Golbasi I, Demircan A, Isin E| title=Bronchogenic cyst. | journal=Tex Heart Inst J | year= 2003 | volume= 30 | issue= 2 | pages= 105-8 | pmid=12809250 | doi= | pmc=161894 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12809250  }} </ref>
*[[Asthenia]]
*[[Asthenia]]<ref name="pmid31348319">{{cite journal| author=Bian B, Yu M, Liu S, Li S, Wei Y, Zhang B| title=A suprasellar bronchogenic cyst: A case report. | journal=Medicine (Baltimore) | year= 2019 | volume= 98 | issue= 30 | pages= e16650 | pmid=31348319 | doi=10.1097/MD.0000000000016650 | pmc=6709100 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=31348319  }} </ref><ref name="pmid26097578">{{cite journal| author=Zou MX, Hu JR, Kang YJ, Li J, Lv GH, She XL| title=Bronchogenic cyst of the conus medullaris with spinal cord tethering: a case report and review of the literature. | journal=Int J Clin Exp Pathol | year= 2015 | volume= 8 | issue= 4 | pages= 3937-42 | pmid=26097578 | doi= | pmc=4466965 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26097578  }} </ref><ref name="pmid29390371">{{cite journal| author=Lee HD, Han SH, Park SB, Ko Y, Lee KH| title=An intradural extramedullary bronchogenic cyst in the thoracolumbar spine: A case report. | journal=Medicine (Baltimore) | year= 2017 | volume= 96 | issue= 50 | pages= e9263 | pmid=29390371 | doi=10.1097/MD.0000000000009263 | pmc=5815783 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29390371  }} </ref>
*[[Foot drop]]
*[[Foot drop]]<ref name="pmid28762109">{{cite journal| author=Candy N, Young A, Devadass A, Dean A, McMillen J, Trivedi R| title=Dual lumbar bronchogenic and arachnoid cyst presenting with sciatica and left foot drop. | journal=Acta Neurochir (Wien) | year= 2017 | volume= 159 | issue= 10 | pages= 2029-2032 | pmid=28762109 | doi=10.1007/s00701-017-3284-z | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28762109  }} </ref>
*[[Atrophy]]
*[[Atrophy]]<ref name="pmid29390371">{{cite journal| author=Lee HD, Han SH, Park SB, Ko Y, Lee KH| title=An intradural extramedullary bronchogenic cyst in the thoracolumbar spine: A case report. | journal=Medicine (Baltimore) | year= 2017 | volume= 96 | issue= 50 | pages= e9263 | pmid=29390371 | doi=10.1097/MD.0000000000009263 | pmc=5815783 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29390371  }} </ref>
*[[Heart murmur]]
*[[Heart murmur]]<ref name="pmid25750196">{{cite journal| author=Hayabuchi Y, Sakata M, Kagami S| title=Bronchogenic cyst compressing the pulmonary artery and the left atrium. | journal=Eur Heart J Cardiovasc Imaging | year= 2015 | volume= 16 | issue= 7 | pages= 746 | pmid=25750196 | doi=10.1093/ehjci/jev059 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25750196  }} </ref><ref name="pmid29897508">{{cite journal| author=Blesneac C, Horvath E, Muntean I, Benedek T, Toganel R| title=Intracardiac bronchogenic cyst associated with ventricular septal defect: an extremely rare feature in children. | journal=Eur Heart J Cardiovasc Imaging | year= 2018 | volume= 19 | issue= 9 | pages= 1074 | pmid=29897508 | doi=10.1093/ehjci/jey078 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29897508  }} </ref>
*[[Tenderness]]
*[[Tenderness]]<ref name="pmid26097578">{{cite journal| author=Zou MX, Hu JR, Kang YJ, Li J, Lv GH, She XL| title=Bronchogenic cyst of the conus medullaris with spinal cord tethering: a case report and review of the literature. | journal=Int J Clin Exp Pathol | year= 2015 | volume= 8 | issue= 4 | pages= 3937-42 | pmid=26097578 | doi= | pmc=4466965 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26097578  }} </ref>
*Cutanous pigmentation
*Cutanous pigmentation<ref name="pmid26097578">{{cite journal| author=Zou MX, Hu JR, Kang YJ, Li J, Lv GH, She XL| title=Bronchogenic cyst of the conus medullaris with spinal cord tethering: a case report and review of the literature. | journal=Int J Clin Exp Pathol | year= 2015 | volume= 8 | issue= 4 | pages= 3937-42 | pmid=26097578 | doi= | pmc=4466965 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26097578  }} </ref>
*Negative [[Neurological examination|knee]] and [[Neurological examination|ankle reflexes]]
*Negative [[Neurological examination|knee]] and [[Neurological examination|ankle reflexes]]<ref name="pmid26097578">{{cite journal| author=Zou MX, Hu JR, Kang YJ, Li J, Lv GH, She XL| title=Bronchogenic cyst of the conus medullaris with spinal cord tethering: a case report and review of the literature. | journal=Int J Clin Exp Pathol | year= 2015 | volume= 8 | issue= 4 | pages= 3937-42 | pmid=26097578 | doi= | pmc=4466965 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26097578  }} </ref>
*[[Hypoesthesia|Numbness]]
*[[Hypoesthesia|Numbness]]<ref name="pmid26097578">{{cite journal| author=Zou MX, Hu JR, Kang YJ, Li J, Lv GH, She XL| title=Bronchogenic cyst of the conus medullaris with spinal cord tethering: a case report and review of the literature. | journal=Int J Clin Exp Pathol | year= 2015 | volume= 8 | issue= 4 | pages= 3937-42 | pmid=26097578 | doi= | pmc=4466965 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26097578  }} </ref><ref name="pmid30702626">{{cite journal| author=Chen F, Marx S, Zhang C, Cao J, Yu Y, Chen D| title=Intramedullary bronchogenic cyst in the foramen magnum region accompanied with syringomyelia: A case report and literature review. | journal=Medicine (Baltimore) | year= 2019 | volume= 98 | issue= 5 | pages= e14353 | pmid=30702626 | doi=10.1097/MD.0000000000014353 | pmc=6380722 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30702626  }} </ref>
 
==Laboratory findings==
==Laboratory findings==
An elevated serum [[tumor marker|tumor makers]] CA125 and CA19-9, which is usually suggestive of progression/complication.
An elevated serum [[tumor marker|tumor makers]] CA125 and CA19-9, which is usually suggestive of progression/complication.<ref name="pmid26986156">{{cite journal| author=Han C, Lin R, Yu J, Zhang Q, Zhang Y, Liu J | display-authors=etal| title=A Case Report of Esophageal Bronchogenic Cyst and Review of the Literature With an Emphasis on Endoscopic Ultrasonography Appearance. | journal=Medicine (Baltimore) | year= 2016 | volume= 95 | issue= 11 | pages= e3111 | pmid=26986156 | doi=10.1097/MD.0000000000003111 | pmc=4839937 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26986156  }} </ref><ref name="pmid28767594">{{cite journal| author=Wang M, He X, Qiu X, Tian C, Li J, Lv M| title=Retroperitoneal bronchogenic cyst resembling an adrenal tumor with high levels of serum carbohydrate antigen 19-9: A case report. | journal=Medicine (Baltimore) | year= 2017 | volume= 96 | issue= 31 | pages= e7678 | pmid=28767594 | doi=10.1097/MD.0000000000007678 | pmc=5626148 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28767594  }} </ref>
 
==CT==
==CT==
CT scan may be helpful in the diagnosis of bronchogenic [[cyst]]. The density of bronchogenic [[cysts]] is variable from water density to high density due to blood, anthracotic pigment, increased calcium content, or increased protein content of the fluid. Findings on CT scan suggestive of bronchogenic [[cyst]] is an  
CT scan may be helpful in the diagnosis of bronchogenic [[cyst]]. The density of bronchogenic [[cysts]] is variable from water density to high density due to blood, anthracotic pigment, increased calcium content, or increased protein content of the fluid.<ref name="pmid11058643">{{cite journal| author=McAdams HP, Kirejczyk WM, Rosado-de-Christenson ML, Matsumoto S| title=Bronchogenic cyst: imaging features with clinical and histopathologic correlation. | journal=Radiology | year= 2000 | volume= 217 | issue= 2 | pages= 441-6 | pmid=11058643 | doi=10.1148/radiology.217.2.r00nv19441 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11058643  }} </ref><ref name="pmid29939368">{{cite journal| author=Chen TJ, Liao CH, Shen TC| title=Bronchogenic cyst. | journal=QJM | year= 2018 | volume= 111 | issue= 12 | pages= 905 | pmid=29939368 | doi=10.1093/qjmed/hcy140 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29939368  }} </ref> Findings on CT scan suggestive of bronchogenic [[cyst]] is an  
*[[cyst|Cysic mass]] with air-fluid levels.
*[[cyst|Cysic mass]] with air-fluid levels<ref name="pmid23013612">{{cite journal| author=Wang W, Ni Y, Zhang L, Li X, Ke C, Lu Q | display-authors=etal| title=A case report of para-esophageal bronchogenic cyst with esophageal communication. | journal=J Cardiothorac Surg | year= 2012 | volume= 7 | issue=  | pages= 94 | pmid=23013612 | doi=10.1186/1749-8090-7-94 | pmc=3599576 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23013612  }} </ref>
*ovoid and well-defined encapsulated low-density [[cyst|cystic mass]] with no contrast enhancement.
*ovoid and well-defined encapsulated low-density [[cyst|cystic mass]] with no contrast enhancement.<ref name="pmid19015445">{{cite journal| author=Teissier N, Elmaleh-Bergès M, Ferkdadji L, François M, Van den Abbeele T| title=Cervical bronchogenic cysts: usual and unusual clinical presentations. | journal=Arch Otolaryngol Head Neck Surg | year= 2008 | volume= 134 | issue= 11 | pages= 1165-9 | pmid=19015445 | doi=10.1001/archotol.134.11.1165 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19015445  }} </ref><ref name="pmid26986156">{{cite journal| author=Han C, Lin R, Yu J, Zhang Q, Zhang Y, Liu J | display-authors=etal| title=A Case Report of Esophageal Bronchogenic Cyst and Review of the Literature With an Emphasis on Endoscopic Ultrasonography Appearance. | journal=Medicine (Baltimore) | year= 2016 | volume= 95 | issue= 11 | pages= e3111 | pmid=26986156 | doi=10.1097/MD.0000000000003111 | pmc=4839937 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26986156  }} </ref>
*Thin subtle walls.
*Thin subtle walls
 
==MRI==
==MRI==
MRI may be helpful in the diagnosis of bronchogenic [[cyst]]. After contrast injection, enhancement of the [[cyst]] is frequently absent. Findings on MRI suggestive of bronchogenic [[cyst]] include
MRI may be helpful in the diagnosis of bronchogenic [[cyst]]. After contrast injection, enhancement of the [[cyst]] is frequently absent.<ref name="pmid26234845">{{cite journal| author=Olsen M, Mitchell TA, Percival TJ, Helsel BS| title=Interatrial Bronchogenic Cyst Resection. | journal=Ann Thorac Surg | year= 2015 | volume= 100 | issue= 2 | pages= 709-11 | pmid=26234845 | doi=10.1016/j.athoracsur.2014.10.025 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26234845  }} </ref><ref name="pmid26986156">{{cite journal| author=Han C, Lin R, Yu J, Zhang Q, Zhang Y, Liu J | display-authors=etal| title=A Case Report of Esophageal Bronchogenic Cyst and Review of the Literature With an Emphasis on Endoscopic Ultrasonography Appearance. | journal=Medicine (Baltimore) | year= 2016 | volume= 95 | issue= 11 | pages= e3111 | pmid=26986156 | doi=10.1097/MD.0000000000003111 | pmc=4839937 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26986156  }} </ref><ref name="pmid11058643">{{cite journal| author=McAdams HP, Kirejczyk WM, Rosado-de-Christenson ML, Matsumoto S| title=Bronchogenic cyst: imaging features with clinical and histopathologic correlation. | journal=Radiology | year= 2000 | volume= 217 | issue= 2 | pages= 441-6 | pmid=11058643 | doi=10.1148/radiology.217.2.r00nv19441 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11058643  }} </ref><ref name="pmid29939368">{{cite journal| author=Chen TJ, Liao CH, Shen TC| title=Bronchogenic cyst. | journal=QJM | year= 2018 | volume= 111 | issue= 12 | pages= 905 | pmid=29939368 | doi=10.1093/qjmed/hcy140 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29939368  }} </ref> Findings on MRI suggestive of bronchogenic [[cyst]] include
*T1-weighted images show ipointense signal
*T1-weighted images show ipointense signal
*T2-weighted images show hyperintense signal.
*T2-weighted images show hyperintense signal.
==Ultrasound==
==Ultrasound==
[[ultrasound]] may be helpful in the diagnosis of bronchogenic [[cyst]]. Finding on an [[ultrasound]] suggestive of bronchogenic [[cyst]] include
[[ultrasound]] may be helpful in the diagnosis of bronchogenic [[cyst]]. Finding on an [[ultrasound]] suggestive of bronchogenic [[cyst]] include
*On endobronchial [[ultrasound]], an anechoic or hypoechoic fluid-filled solid mass.
*On endobronchial [[ultrasound]], an anechoic or hypoechoic fluid filled solid mass.<ref name="pmid19015445">{{cite journal| author=Teissier N, Elmaleh-Bergès M, Ferkdadji L, François M, Van den Abbeele T| title=Cervical bronchogenic cysts: usual and unusual clinical presentations. | journal=Arch Otolaryngol Head Neck Surg | year= 2008 | volume= 134 | issue= 11 | pages= 1165-9 | pmid=19015445 | doi=10.1001/archotol.134.11.1165 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19015445  }} </ref><ref name="pmid26986156">{{cite journal| author=Han C, Lin R, Yu J, Zhang Q, Zhang Y, Liu J | display-authors=etal| title=A Case Report of Esophageal Bronchogenic Cyst and Review of the Literature With an Emphasis on Endoscopic Ultrasonography Appearance. | journal=Medicine (Baltimore) | year= 2016 | volume= 95 | issue= 11 | pages= e3111 | pmid=26986156 | doi=10.1097/MD.0000000000003111 | pmc=4839937 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26986156  }} </ref><ref name="pmid30846076">{{cite journal| author=Ayub II, Balakrishnan H, Arshad AM, Manimaran N, Thangaswamy D, Chockalingam C| title=A 44-Year-Old Man With Nonproductive Cough and Sensation of Heaviness Over the Upper Chest. | journal=Chest | year= 2019 | volume= 155 | issue= 3 | pages= e65-e68 | pmid=30846076 | doi=10.1016/j.chest.2018.09.035 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30846076  }} </ref>
*On transthoracic echocardiography revealing intracardiac [[cyst|cystic mass]].
*On transthoracic echocardiography revealing intracardiac [[cyst|cystic mass]]<ref name="pmid28139004">{{cite journal| author=Miwa E, Tani T, Okada Y, Furukawa Y| title=A rare cardiac tumor: Bronchogenic cyst of interatrial septum. | journal=Echocardiography | year= 2017 | volume= 34 | issue= 3 | pages= 474-475 | pmid=28139004 | doi=10.1111/echo.13445 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28139004  }} </ref>
*On [[Endoscopy|endoscopic ultrasonography]], which demonstartes abdominal anatomic relations of the [[cyst]].
*On [[Endoscopy|endoscopic ultrasonography]], which demonstartes abdominal anatomic relations of the [[cyst]]<ref name="pmid26986156">{{cite journal| author=Han C, Lin R, Yu J, Zhang Q, Zhang Y, Liu J | display-authors=etal| title=A Case Report of Esophageal Bronchogenic Cyst and Review of the Literature With an Emphasis on Endoscopic Ultrasonography Appearance. | journal=Medicine (Baltimore) | year= 2016 | volume= 95 | issue= 11 | pages= e3111 | pmid=26986156 | doi=10.1097/MD.0000000000003111 | pmc=4839937 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26986156  }} </ref>
 
==Other Diagnostic Studies==
==Other Diagnostic Studies==
Other diagnostic studies for bronchogenic cyst include:
Other diagnostic studies for bronchogenic cyst include:
[[Excision]] and [[H&E stain|Hematoxylin and Eosin staining]], which demonstrates ciliated [[columar epithelia]] cells is definitive for bronchogenic [[cyst]]
[[Excision]] and [[H&E stain|Hematoxylin and Eosin staining]],<ref name="pmid17874358">{{cite journal| author=Chuang KH, Huang TW, Cheng YL, Chen JC, Tzao C, Chang H | display-authors=etal| title=Esophageal bronchogenic cyst: a rare entity. | journal=Z Gastroenterol | year= 2007 | volume= 45 | issue= 9 | pages= 958-60 | pmid=17874358 | doi=10.1055/s-2007-963069 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17874358  }} </ref> which demonstrates cillated [[columar epithelia]] cells is definitive for broncogenic [[cyst]].<ref name="pmid17874358">{{cite journal| author=Chuang KH, Huang TW, Cheng YL, Chen JC, Tzao C, Chang H | display-authors=etal| title=Esophageal bronchogenic cyst: a rare entity. | journal=Z Gastroenterol | year= 2007 | volume= 45 | issue= 9 | pages= 958-60 | pmid=17874358 | doi=10.1055/s-2007-963069 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17874358  }} </ref><ref name="pmid26986156">{{cite journal| author=Han C, Lin R, Yu J, Zhang Q, Zhang Y, Liu J | display-authors=etal| title=A Case Report of Esophageal Bronchogenic Cyst and Review of the Literature With an Emphasis on Endoscopic Ultrasonography Appearance. | journal=Medicine (Baltimore) | year= 2016 | volume= 95 | issue= 11 | pages= e3111 | pmid=26986156 | doi=10.1097/MD.0000000000003111 | pmc=4839937 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26986156  }} </ref><ref name="pmid31462259">{{cite journal| author=Yang X, Zong Y, Zhao HY, Wu YD, Ji M| title=Complete excision of esophageal bronchogenic cyst by endoscopic submucosal tunnel dissection: a case presentation. | journal=BMC Gastroenterol | year= 2019 | volume= 19 | issue= 1 | pages= 155 | pmid=31462259 | doi=10.1186/s12876-019-1072-3 | pmc=6714396 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=31462259  }} </ref><ref name="pmid8902460">{{cite journal| author=Aktoğu S, Yuncu G, Halilçolar H, Ermete S, Buduneli T| title=Bronchogenic cysts: clinicopathological presentation and treatment. | journal=Eur Respir J | year= 1996 | volume= 9 | issue= 10 | pages= 2017-21 | pmid=8902460 | doi=10.1183/09031936.96.09102017 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8902460  }} </ref>
*[[Immunohistochemistry|Immunohistochemical staining]] of bronchogenic [[cyst]] of the esophagus , which demonstrates a positive expression of CA199 and CA125.
*[[Immunohistochemistry|Immunohistochemical staining]] of bronchogenic [[cyst]] of esophagus , whcich demonstartes a positive expression of CA199 and CA125.<ref name="pmid26986156">{{cite journal| author=Han C, Lin R, Yu J, Zhang Q, Zhang Y, Liu J | display-authors=etal| title=A Case Report of Esophageal Bronchogenic Cyst and Review of the Literature With an Emphasis on Endoscopic Ultrasonography Appearance. | journal=Medicine (Baltimore) | year= 2016 | volume= 95 | issue= 11 | pages= e3111 | pmid=26986156 | doi=10.1097/MD.0000000000003111 | pmc=4839937 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26986156  }} </ref>
*[[Bronchoscopy]], which demonstrates pink [[cyst|cystic mass]] with bronchial attachment
*[[Bronchoscopy]], which demonstrates pink [[cyst|cystic mass]] with bronchial attachment<ref name="pmid12809250">{{cite journal| author=Sarper A, Ayten A, Golbasi I, Demircan A, Isin E| title=Bronchogenic cyst. | journal=Tex Heart Inst J | year= 2003 | volume= 30 | issue= 2 | pages= 105-8 | pmid=12809250 | doi= | pmc=161894 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12809250  }} </ref>
*[[endoscopy|Gastroendoscopy]] which demonstartes abdominal anatomic relations of the [[cyst]].
*[[endoscopy|Gastroendoscopy]] which demonstartes abdominal anatomic relations of the [[cyst]].<ref name="pmid26986156">{{cite journal| author=Han C, Lin R, Yu J, Zhang Q, Zhang Y, Liu J | display-authors=etal| title=A Case Report of Esophageal Bronchogenic Cyst and Review of the Literature With an Emphasis on Endoscopic Ultrasonography Appearance. | journal=Medicine (Baltimore) | year= 2016 | volume= 95 | issue= 11 | pages= e3111 | pmid=26986156 | doi=10.1097/MD.0000000000003111 | pmc=4839937 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26986156  }} </ref><ref name="pmid26823885">{{cite journal| author=Gou Y, Wang Y, Fang H, Xu X, Yu W, Zhang K | display-authors=etal| title=Bronchogenic cyst in the hepatogastric ligament masquerading as an esophageal mesenchymal tumor: a case report. | journal=Int J Clin Exp Pathol | year= 2015 | volume= 8 | issue= 11 | pages= 15307-11 | pmid=26823885 | doi= | pmc=4713671 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26823885  }} </ref>
*[[fluorodeoxyglucose]]-[[positron emission tomography]] to confirm [[cyst]] infection.
*[[fluorodeoxyglucose]]-[[positron emission tomography]] to confirm [[cyst]] infection<ref name="pmid30098916">{{cite journal| author=Yildiz H, Reichwein R, Poncelet A, Lacroix V, D'abadie P, Ghaye B | display-authors=etal| title=An unusual case of cardiac tamponade: Bronchogenic cyst infection due to Salmonella bredeney. | journal=J Infect Chemother | year= 2019 | volume= 25 | issue= 2 | pages= 151-153 | pmid=30098916 | doi=10.1016/j.jiac.2018.07.012 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30098916  }} </ref>
 
==Treatment==
==Treatment==
===Medical therapy===
===Medical therapy===
The mainstay of treatment for bronchogenic [[cyst]] is [[Bronchogenic cyst surgery|surgery]].
The mainstay of treatment for bronchogenic [[cyst]] is [[Bronchogenic cyst surgery|surgery]].
===Surgery===
===Surgery===
Surgery is the mainstay of treatment for bronchogenic [[cyst]] even when the patients are asymptomatic, a conservative approach is not approved.
Surgery is the mainstay of treatment for bronchogenic [[cyst]] even when the patients are asymptomatic,<ref name="pmid31462259">{{cite journal| author=Yang X, Zong Y, Zhao HY, Wu YD, Ji M| title=Complete excision of esophageal bronchogenic cyst by endoscopic submucosal tunnel dissection: a case presentation. | journal=BMC Gastroenterol | year= 2019 | volume= 19 | issue= 1 | pages= 155 | pmid=31462259 | doi=10.1186/s12876-019-1072-3 | pmc=6714396 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=31462259  }} </ref>conservative approach is not approved.<ref name="pmid8902460">{{cite journal| author=Aktoğu S, Yuncu G, Halilçolar H, Ermete S, Buduneli T| title=Bronchogenic cysts: clinicopathological presentation and treatment. | journal=Eur Respir J | year= 1996 | volume= 9 | issue= 10 | pages= 2017-21 | pmid=8902460 | doi=10.1183/09031936.96.09102017 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8902460  }} </ref> 
 
==Primary prevention==
==Primary prevention==
There are no established measures for the primary prevention of bronchogenic [[cyst]].
There are no established measures for the primary prevention of bronchogenic [[cyst]].

Revision as of 01:51, 14 July 2020

Bronchogenic cyst Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Joanna Ekabua, M.D. [2]

Overview

Bronchogenic cyst is a rare benign congenital malformation of the tracheobronchial tree derived from the ventral aspect of the foregut. It most frequently occurs in the middle mediastinum, in the early stages of gestation or in the lungs, at the later stages of gestation. Atypical locations may be explained by its embryologic origin. Patients with bronchogenic cyst may be asymptomatic or present with respiratory distress, increasing stridor, feeding difficulties, chest pain, cough, progressive dysphagia, odynophagia, purulent sputum, dyspnea, anorexia and/orweight loss. Radiologic findings are useful to differentiate bronchogenic cysts from other cysts but may they not always confirm the diagnosis. Diagnosis is confirmed by surgical excision, which is curative, and histological findings of ciliated columnar epithelial lining of the cyst.

Historical Perspective

There is limited information about the historical perspective of bronchogenic cyst.

Classification

Bronchogenic cyst can be classified based on location; pulmonary and extrapulmonary.[1][2]

Pathophysiology

It is thought that bronchogenic cyst is the result of abnormal budding of the ventral portion of the primitive foregut between days 26 - 40 of gestation.

Causes

The cause of bronchogenic cysts is undetermined.

Differentiating Bronchogenic cyst from other Diseases

Differentiating bronchogenic cyst from lung abcess, thymic cyst, and esophageal duplication cysts.

Bronchogenic cyst epidemiology and demographics|Epidemiology and Demographics

There is no racial predilection to bronchogenic cyst. Bronchogenic cyst is slightly more prevalent in men and often remain undetected till the third or fourth decade of life.[3][4]

Risk factors

There are no established risk factors for bronchogenic cyst.

Screening

There is insufficient evidence to recommend routine screening for bronchogenic cyst as it is usually an incidental finding.

Natural history, complications and prognosis

Natural History

The symptoms of bronchogenic cyst usually develop in the third to fourth decade of life and start with symptoms such as

Complication

Common complications of bronchogenic cyst include

Prognosis

Prognosis is generally good,[19] a Morbidity & Mortality rate of 20% has been recorded in older patients treated for bronchogenic cyst.[26]

Diagnostic Study of Choice

Excision and Hematoxylin and Eosin staining[23]

Diagnostic results

Cillated columar epithelia cells is definitive for broncogenic cyst.[23][24][20][4]

Diagnostic criteria

Cystic mass producing compressive symptoms.

History and symptoms

The majority of patients with bronchogenic cyst are asymptomatic and are diagnosed during investigations for other pathologies.[1][20][27]

When symptomatic, clinical presentation of bronchogenic cyst depends on the age of the patient, size and the location of the cyst.[1][28]

In infants bronchogenic cyst presents with [19][18][29][28][30][31][32]

In children and adults, bronchogenic cyst presents with

Physical examinaton

Physical examination of patients with bronchogenic cyst is usually normal. On rare occasions, the following signs can be seen

Laboratory findings

An elevated serum tumor makers CA125 and CA19-9, which is usually suggestive of progression/complication.[24][39]

CT

CT scan may be helpful in the diagnosis of bronchogenic cyst. The density of bronchogenic cysts is variable from water density to high density due to blood, anthracotic pigment, increased calcium content, or increased protein content of the fluid.[40][41] Findings on CT scan suggestive of bronchogenic cyst is an

MRI

MRI may be helpful in the diagnosis of bronchogenic cyst. After contrast injection, enhancement of the cyst is frequently absent.[7][24][40][41] Findings on MRI suggestive of bronchogenic cyst include

  • T1-weighted images show ipointense signal
  • T2-weighted images show hyperintense signal.

Ultrasound

ultrasound may be helpful in the diagnosis of bronchogenic cyst. Finding on an ultrasound suggestive of bronchogenic cyst include

Other Diagnostic Studies

Other diagnostic studies for bronchogenic cyst include: Excision and Hematoxylin and Eosin staining,[23] which demonstrates cillated columar epithelia cells is definitive for broncogenic cyst.[23][24][20][4]

Treatment

Medical therapy

The mainstay of treatment for bronchogenic cyst is surgery.

Surgery

Surgery is the mainstay of treatment for bronchogenic cyst even when the patients are asymptomatic,[20]conservative approach is not approved.[4]

Primary prevention

There are no established measures for the primary prevention of bronchogenic cyst.

Secondaryy prevention

There are no established measures for the secondary prevention of bronchogenic cyst.


References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Maier HC (1948). "Bronchiogenic Cysts of the Mediastinum". Ann Surg. 127 (3): 476–502. doi:10.1097/00000658-194803000-00010. PMC 1513836. PMID 17859095.
  2. ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 2.14 2.15 2.16 2.17 2.18 Sarper A, Ayten A, Golbasi I, Demircan A, Isin E (2003). "Bronchogenic cyst". Tex Heart Inst J. 30 (2): 105–8. PMC 161894. PMID 12809250.
  3. ↑ Lardinois D, Gugger M, Ris HB (1999). "Bronchogenic cyst of the left lower lobe associated with severe hemoptysis". Eur J Cardiothorac Surg. 16 (3): 382–3. doi:10.1016/s1010-7940(99)00226-2. PMID 10554866.
  4. ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 Aktoğu S, Yuncu G, Halilçolar H, Ermete S, Buduneli T (1996). "Bronchogenic cysts: clinicopathological presentation and treatment". Eur Respir J. 9 (10): 2017–21. doi:10.1183/09031936.96.09102017. PMID 8902460.
  5. ↑ 5.0 5.1 5.2 5.3 Mesland JB, Gérard L, Van Caenegem O, Castanares-Zapatero D (2018). "Bronchogenic cyst infection presenting as pleuropericarditis". BMJ Case Rep. 2018. doi:10.1136/bcr-2018-225081. PMC 6011476. PMID 29895549.
  6. ↑ 6.0 6.1 6.2 6.3 6.4 Yildiz H, Reichwein R, Poncelet A, Lacroix V, D'abadie P, Ghaye B; et al. (2019). "An unusual case of cardiac tamponade: Bronchogenic cyst infection due to Salmonella bredeney". J Infect Chemother. 25 (2): 151–153. doi:10.1016/j.jiac.2018.07.012. PMID 30098916.
  7. ↑ 7.0 7.1 7.2 Olsen M, Mitchell TA, Percival TJ, Helsel BS (2015). "Interatrial Bronchogenic Cyst Resection". Ann Thorac Surg. 100 (2): 709–11. doi:10.1016/j.athoracsur.2014.10.025. PMID 26234845.
  8. ↑ 8.0 8.1 DiBardino DM, Brenner K (2017). "Bronchogenic Cyst Abscess". J Bronchology Interv Pulmonol. 24 (3): 31–32. doi:10.1097/LBR.0000000000000375. PMID 28696968.
  9. ↑ 9.0 9.1 Chumakova M, Morris-Stiff G, Khachaturov V, Ibrahim S (2016). "Bronchogenic cyst arising from the crus of the left hemidiaphragm". BMJ Case Rep. 2016. doi:10.1136/bcr-2015-213658. PMC 4840741. PMID 27068723.
  10. ↑ 10.0 10.1 10.2 Chen F, Marx S, Zhang C, Cao J, Yu Y, Chen D (2019). "Intramedullary bronchogenic cyst in the foramen magnum region accompanied with syringomyelia: A case report and literature review". Medicine (Baltimore). 98 (5): e14353. doi:10.1097/MD.0000000000014353. PMC 6380722. PMID 30702626.
  11. ↑ 11.0 11.1 Mega S (2015). "[Anterior Mediastinal Bronchogenic Cyst Associated with paroxysmal supraventricular tachycardia ; Report of a Case]". Kyobu Geka. 68 (10): 871–3. PMID 26329634.
  12. ↑ 12.0 12.1 12.2 Miwa E, Tani T, Okada Y, Furukawa Y (2017). "A rare cardiac tumor: Bronchogenic cyst of interatrial septum". Echocardiography. 34 (3): 474–475. doi:10.1111/echo.13445. PMID 28139004.
  13. ↑ 13.0 13.1 13.2 13.3 13.4 Bian B, Yu M, Liu S, Li S, Wei Y, Zhang B (2019). "A suprasellar bronchogenic cyst: A case report". Medicine (Baltimore). 98 (30): e16650. doi:10.1097/MD.0000000000016650. PMC 6709100 Check |pmc= value (help). PMID 31348319.
  14. ↑ 14.00 14.01 14.02 14.03 14.04 14.05 14.06 14.07 14.08 14.09 14.10 Zou MX, Hu JR, Kang YJ, Li J, Lv GH, She XL (2015). "Bronchogenic cyst of the conus medullaris with spinal cord tethering: a case report and review of the literature". Int J Clin Exp Pathol. 8 (4): 3937–42. PMC 4466965. PMID 26097578.
  15. ↑ 15.0 15.1 15.2 15.3 15.4 Lee HD, Han SH, Park SB, Ko Y, Lee KH (2017). "An intradural extramedullary bronchogenic cyst in the thoracolumbar spine: A case report". Medicine (Baltimore). 96 (50): e9263. doi:10.1097/MD.0000000000009263. PMC 5815783. PMID 29390371.
  16. ↑ 16.0 16.1 16.2 Khawar M, Elmahrouk A, Chaikhouni A (2016). "Air embolism during air flight in a passenger with bronchogenic cyst". J Thorac Cardiovasc Surg. 152 (1): e1–2. doi:10.1016/j.jtcvs.2016.02.014. PMID 26969135.
  17. ↑ 17.0 17.1 Xu Q, Feng Y, Ye K, Zhou Y, Zhan R (2015). "Bronchogenic cyst in left anterior cranial fossa". Neurology. 84 (11): 1181–2. doi:10.1212/WNL.0000000000001368. PMID 25780019.
  18. ↑ 18.0 18.1 18.2 18.3 18.4 Ribet ME, Copin MC, Gosselin BH (1996). "Bronchogenic cysts of the lung". Ann Thorac Surg. 61 (6): 1636–40. doi:10.1016/0003-4975(96)00172-5. PMID 8651761.
  19. ↑ 19.0 19.1 19.2 19.3 19.4 19.5 19.6 19.7 Teissier N, Elmaleh-Bergès M, Ferkdadji L, François M, Van den Abbeele T (2008). "Cervical bronchogenic cysts: usual and unusual clinical presentations". Arch Otolaryngol Head Neck Surg. 134 (11): 1165–9. doi:10.1001/archotol.134.11.1165. PMID 19015445.
  20. ↑ 20.0 20.1 20.2 20.3 20.4 20.5 20.6 20.7 Yang X, Zong Y, Zhao HY, Wu YD, Ji M (2019). "Complete excision of esophageal bronchogenic cyst by endoscopic submucosal tunnel dissection: a case presentation". BMC Gastroenterol. 19 (1): 155. doi:10.1186/s12876-019-1072-3. PMC 6714396 Check |pmc= value (help). PMID 31462259.
  21. ↑ 21.0 21.1 Hayabuchi Y, Sakata M, Kagami S (2015). "Bronchogenic cyst compressing the pulmonary artery and the left atrium". Eur Heart J Cardiovasc Imaging. 16 (7): 746. doi:10.1093/ehjci/jev059. PMID 25750196.
  22. ↑ Parsons C, Zhao CB, Huang J (2019). "Gigantic Pericardial Bronchogenic Cyst Compressing Superior Vena Cava and Coronary Artery". Anesthesiology. 131 (3): 667. doi:10.1097/ALN.0000000000002739. PMID 31008767.
  23. ↑ 23.0 23.1 23.2 23.3 23.4 23.5 23.6 23.7 Chuang KH, Huang TW, Cheng YL, Chen JC, Tzao C, Chang H; et al. (2007). "Esophageal bronchogenic cyst: a rare entity". Z Gastroenterol. 45 (9): 958–60. doi:10.1055/s-2007-963069. PMID 17874358.
  24. ↑ 24.00 24.01 24.02 24.03 24.04 24.05 24.06 24.07 24.08 24.09 24.10 24.11 24.12 24.13 24.14 Han C, Lin R, Yu J, Zhang Q, Zhang Y, Liu J; et al. (2016). "A Case Report of Esophageal Bronchogenic Cyst and Review of the Literature With an Emphasis on Endoscopic Ultrasonography Appearance". Medicine (Baltimore). 95 (11): e3111. doi:10.1097/MD.0000000000003111. PMC 4839937. PMID 26986156.
  25. ↑ 25.0 25.1 25.2 Blesneac C, Horvath E, Muntean I, Benedek T, Toganel R (2018). "Intracardiac bronchogenic cyst associated with ventricular septal defect: an extremely rare feature in children". Eur Heart J Cardiovasc Imaging. 19 (9): 1074. doi:10.1093/ehjci/jey078. PMID 29897508.
  26. ↑ Makhija Z, Moir CR, Allen MS, Cassivi SD, Deschamps C, Nichols FC; et al. (2011). "Surgical management of congenital cystic lung malformations in older patients". Ann Thorac Surg. 91 (5): 1568–73, discussion 1573. doi:10.1016/j.athoracsur.2011.01.080. PMID 21420068.
  27. ↑ Ramenofsky ML, Leape LL, McCauley RG (1979). "Bronchogenic cyst". J Pediatr Surg. 14 (3): 219–24. doi:10.1016/s0022-3468(79)80474-1. PMID 480084.
  28. ↑ 28.0 28.1 28.2 Jiang JH, Yen SL, Lee SY, Chuang JH (2015). "Differences in the distribution and presentation of bronchogenic cysts between adults and children". J Pediatr Surg. 50 (3): 399–401. doi:10.1016/j.jpedsurg.2014.06.008. PMID 25746696.
  29. ↑ 29.0 29.1 29.2 29.3 29.4 Hsu CG, Heller M, Johnston GS, Felberbaum M (2017). "An Unusual Cause of Airway Compromise in the Emergency Department: Mediastinal Bronchogenic Cyst". J Emerg Med. 52 (3): e91–e93. doi:10.1016/j.jemermed.2016.11.004. PMID 27986331.
  30. ↑ Lin JS, Yu YR, Chiou EH, Chumpitazi BP, Schady DA, Brandt ML (2017). "Intramural esophageal bronchogenic cyst mimicking achalasia in a toddler". Pediatr Surg Int. 33 (1): 119–123. doi:10.1007/s00383-016-3994-y. PMID 27822780.
  31. ↑ 31.0 31.1 Thaller P, Blanchet C, Badr M, Mesnage R, Leboucq N, Mondain M; et al. (2015). "Neonatal respiratory distress syndrome revealing a cervical bronchogenic cyst: a case report". BMC Pediatr. 15: 72. doi:10.1186/s12887-015-0363-2. PMC 4491209. PMID 26112048.
  32. ↑ Brugha R, Semple T, Cook J, Dusmet M, Rosenthal M (2018). "Two Bronchogenic Cysts Causing Tracheal Stenosis in an Infant". Am J Respir Crit Care Med. 197 (2): 261–262. doi:10.1164/rccm.201708-1611IM. PMID 29099998.
  33. ↑ Legras A, Mordant P, Gibault L, Hernigou A, Le Pimpec Barthes F, Riquet M (2014). "[Diaphragmatic bronchogenic cyst: an exceptional location]". Rev Pneumol Clin. 70 (6): 357–61. doi:10.1016/j.pneumo.2014.05.002. PMID 25131363.
  34. ↑ 34.0 34.1 34.2 Ayub II, Balakrishnan H, Arshad AM, Manimaran N, Thangaswamy D, Chockalingam C (2019). "A 44-Year-Old Man With Nonproductive Cough and Sensation of Heaviness Over the Upper Chest". Chest. 155 (3): e65–e68. doi:10.1016/j.chest.2018.09.035. PMID 30846076.
  35. ↑ 35.0 35.1 Gou Y, Wang Y, Fang H, Xu X, Yu W, Zhang K; et al. (2015). "Bronchogenic cyst in the hepatogastric ligament masquerading as an esophageal mesenchymal tumor: a case report". Int J Clin Exp Pathol. 8 (11): 15307–11. PMC 4713671. PMID 26823885.
  36. ↑ 36.0 36.1 Candy N, Young A, Devadass A, Dean A, McMillen J, Trivedi R (2017). "Dual lumbar bronchogenic and arachnoid cyst presenting with sciatica and left foot drop". Acta Neurochir (Wien). 159 (10): 2029–2032. doi:10.1007/s00701-017-3284-z. PMID 28762109.
  37. ↑ 37.0 37.1 Atoini F, Ouarssani A, Ouadnouni Y, Smahi M (2016). "Unusual mode of presentation of intrathoracic bronchogenic cyst: A double location". Respir Med Case Rep. 17: 12–6. doi:10.1016/j.rmcr.2015.10.001. PMC 4821250. PMID 27222776.
  38. ↑ Nachef Z, Harris K, Dhillon SS (2018). "Bronchogenic Cyst: Fluid-thrill Sign on Endobronchial Ultrasound". J Bronchology Interv Pulmonol. 25 (3): 224–227. doi:10.1097/LBR.0000000000000473. PMID 29389833.
  39. ↑ Wang M, He X, Qiu X, Tian C, Li J, Lv M (2017). "Retroperitoneal bronchogenic cyst resembling an adrenal tumor with high levels of serum carbohydrate antigen 19-9: A case report". Medicine (Baltimore). 96 (31): e7678. doi:10.1097/MD.0000000000007678. PMC 5626148. PMID 28767594.
  40. ↑ 40.0 40.1 McAdams HP, Kirejczyk WM, Rosado-de-Christenson ML, Matsumoto S (2000). "Bronchogenic cyst: imaging features with clinical and histopathologic correlation". Radiology. 217 (2): 441–6. doi:10.1148/radiology.217.2.r00nv19441. PMID 11058643.
  41. ↑ 41.0 41.1 Chen TJ, Liao CH, Shen TC (2018). "Bronchogenic cyst". QJM. 111 (12): 905. doi:10.1093/qjmed/hcy140. PMID 29939368.
  42. ↑ Wang W, Ni Y, Zhang L, Li X, Ke C, Lu Q; et al. (2012). "A case report of para-esophageal bronchogenic cyst with esophageal communication". J Cardiothorac Surg. 7: 94. doi:10.1186/1749-8090-7-94. PMC 3599576. PMID 23013612.

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