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| [[Image:Home_logo1.png|right|250px|link=https://www.wikidoc.org/index.php/Single-page_with_differential_diagnosis_table]] | | [[Image:Home_logo1.png|right|250px|link=https://www.wikidoc.org/index.php/Single-page_with_differential_diagnosis_table]] |
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| {{CMG}}; {{AE}}{{TAM}} | | {{CMG}}; {{AE}} |
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| | <STRONG><FONT SIZE=5>This is the template for the “Differential Diagnosis Page” of a single-page <u>with</u> differential diagnosis table(s).</FONT></STRONG> |
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| | <STRONG><FONT SIZE=5>Please link the “Return to Home” button to the “Main Page”.</FONT></STRONG> |
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| ==Overview== | | ==Overview== |
| COVID-19-associated hepatic Injury must be differentiated from other conditions that may cause elevation of [[liver enzymes]].
| | Disease_Name must be differentiated from Disease_A, Disease_B, and Disease_C. |
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| ==Differential Diagnosis== | | ==Differential Diagnosis== |
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| COVID-19-associated hepatic Injury must be differentiated from other conditions that may cause elevation of [[liver enzymes]].
| | Disease_Name must be differentiated from Disease_A, Disease_B, and Disease_C. |
| {|
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| |- style="background: #4479BA; color: #FFFFFF; text-align: center;"
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| ! colspan="2" rowspan="3" align="center" style="background:#4479BA; color: #FFFFFF;" |Disease
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| ! colspan="5" align="center" style="background:#4479BA; color: #FFFFFF;" |Clinical manifestations
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| ! colspan="3" align="center" style="background:#4479BA; color: #FFFFFF;" |Laboratory findings
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| ! rowspan="3" align="center" style="background:#4479BA; color: #FFFFFF;" |Additional findings
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| |-
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| ! colspan="3" align="center" style="background:#4479BA; color: #FFFFFF;" |Symptoms
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| ! colspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |Signs
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| ! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |Transaminitis (elevated AST and ALT)
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| ! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |Viral markers
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| ! rowspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |Autoimmune markers
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| |-
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| ! align="center" style="background:#4479BA; color: #FFFFFF;" |Nausea & vomiting
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| ! align="center" style="background:#4479BA; color: #FFFFFF;" |Abdominal pain
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| ! align="center" style="background:#4479BA; color: #FFFFFF;" |Arthralgia
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| ! align="center" style="background:#4479BA; color: #FFFFFF;" |Jaundice
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| ! align="center" style="background:#4479BA; color: #FFFFFF;" |Hepatomegaly
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| |-
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| | rowspan="6" style="background:#4479BA; color: #FFFFFF" |Acute viral hepatitis
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| | style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hepatitis A]]
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +++
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | ++
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +++
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +++
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[HAV]] Ab
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | ---
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| | style="padding: 5px 5px; background: #F5F5F5;" align="left" |
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| * Fecal-oral transmission
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| * Usually acute and self limit
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| * [[Fever]] usually present
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| |-
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| | style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hepatitis B]]
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +++
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | ++
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | ++
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +++
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +++
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |HBs Ag, HBc Ab, HBe Ag
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | ---
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| | style="padding: 5px 5px; background: #F5F5F5;" align="left" |
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| * Percutaneous transmission most common
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| * May cause acute hepatic failure or may become chronic
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| * [[Fever]] usually present
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| |-
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| | style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hepatitis C]]
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | +++
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>++</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>++</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>+++</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>+</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>+++</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |HCV Ab
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>---</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="left" |
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| * Percutaneous transmission is most common
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| * Higher rate of chronic progression
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| * Associated with extra hepatic manifestation such as [[cryoglobulinemia]] and [[membranoproliferative glomerulonephritis]]
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| * [[Fever]] usually present
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| |-
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| | style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hepatitis E]]
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>++</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>++</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>+/-</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>++</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>+</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>+++</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |HEV Ab
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>---</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="left" |
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| * Fecal-oral transmission
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| * May cause fulminant disease in pregnancy
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| * [[Fever]] usually present
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| |-
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| | style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Cytomegalovirus infection natural history, complications and prognosis|CMV hepatitis]]
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>+/-</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>++</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>-</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>+</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>+</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>++</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |CMV-specific immunoglobulin (Ig)M antibody
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>--</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="left" |
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| * Usually manifests as mononucleosis syndrome
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| * [[fever]] usually present
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| |-
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| | style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[EBV]] hepatitis
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>+/-</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>++</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>-</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>+/-</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>+</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>++</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Antibody|Heterophile antibody test]], monospot test
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>--</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="left" |
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| * Systemic manifestations as mononucleosis syndrome
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| * Fever usually present
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| |-
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| | colspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |Autoimmune hepatitis
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>-</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>+</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>+/-</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>++</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>+</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>+++</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>---</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Antinuclear antibodies|ANA]], [[Anti-SM antibody|ASMA]], anti SLA/LP, [[ANCA]], ALKM-1 antibodies
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| | style="padding: 5px 5px; background: #F5F5F5;" align="left" |
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| * Liver biopsy may be required for diagnosis
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| |-
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| | colspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |Alcoholic hepatitis
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>+/-</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>+</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>-</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>+</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>-</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aspartate transaminase|AST]]>[[Alanine transaminase|ALT]]
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" | ---
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>---</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="left" |
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| * History of alcohol intake
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| |-
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| | colspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |Drug induced hepatitis
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>+/-</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>+</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>-</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>+</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>+</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>++</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>---</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>---</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="left" |
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| * May cause either cholestatic or hepatocellular injury
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| |-
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| | colspan="2" align="center" style="background:#4479BA; color: #FFFFFF;" |Drug
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>+/-</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>+</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>-</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>+</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>+</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>++</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>---</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="center" |<nowiki>---</nowiki>
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| | style="padding: 5px 5px; background: #F5F5F5;" align="left" |
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| * May cause either cholestatic or hepatocellular injury
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| |}
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| | (Insert the differential diagnosis table below) |
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| == References == | | == References == |
| {{reflist|2}} | | {{reflist|2}} |