Lymphadenopathy other diagnostic studies: Difference between revisions
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==Other Diagnostic Studies== | ==Other Diagnostic Studies== | ||
Indications for a lymph node biopsy include: | Indications for a lymph node biopsy include:<ref name="pmid10">{{cite journal |vauthors=Schmoldt A, Benthe HF, Haberland G, Durham BH, Chiu FT, Tsui FP, Zon G |title=Digitoxin metabolism by rat liver microsomes |journal=Biochem Pharmacol |volume=24 |issue=17 |pages=1639–41 |date=September 1975 |pmid=10 |doi=10.1021/jm00193a010 |url=}}</ref> | ||
* Swollen glands that do not go away even after the infection has subsided | * Swollen glands that do not go away even after the infection has subsided | ||
* Presence of lymph nodes on a [[CT]] or [[MRI]] scan | * Presence of lymph nodes on a [[CT]] or [[MRI]] scan | ||
* Spread of [[breast cancer]] or [[melanoma]] (sentinel lymph node biopsy) | * Spread of [[breast cancer]] or [[melanoma]] (sentinel lymph node biopsy) | ||
Three types of biopsy methods can be used to diagnose swollen lymph nodes. They are: | Three types of biopsy methods can be used to diagnose swollen lymph nodes. They are: | ||
* ''Fine needle aspiration cytology''- thin needle is used to take samples from the lymph node. Usually used for recurrent cancers. Lacks information about tissue architecture. False positives are common. | * ''Fine needle aspiration cytology''- a thin needle is used to take samples from the lymph node. Usually used for recurrent cancers. Lacks information about tissue architecture. False positives are common. | ||
* ''Core needle biopsy''- a specialized needle is used to take a sample of tissue from the lymph node. Provides some detail about architecture. | * ''Core needle biopsy''- a specialized needle is used to take a sample of tissue from the lymph node. Provides some detail about architecture. The tissue sample can be used for other special studies. | ||
* ''Open biopsy''- best diagnostic biopsy method, because the tissue taken is intact and will provide finer details about the presence of abnormal cells and structure of the lymph node. Performed under local anesthesia. | * ''Open biopsy''- best diagnostic biopsy method, because the tissue taken is intact and will provide finer details about the presence of abnormal cells and structure of the lymph node. Performed under local anesthesia. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]
Other Diagnostic Studies
Indications for a lymph node biopsy include:[1]
- Swollen glands that do not go away even after the infection has subsided
- Presence of lymph nodes on a CT or MRI scan
- Spread of breast cancer or melanoma (sentinel lymph node biopsy)
Three types of biopsy methods can be used to diagnose swollen lymph nodes. They are:
- Fine needle aspiration cytology- a thin needle is used to take samples from the lymph node. Usually used for recurrent cancers. Lacks information about tissue architecture. False positives are common.
- Core needle biopsy- a specialized needle is used to take a sample of tissue from the lymph node. Provides some detail about architecture. The tissue sample can be used for other special studies.
- Open biopsy- best diagnostic biopsy method, because the tissue taken is intact and will provide finer details about the presence of abnormal cells and structure of the lymph node. Performed under local anesthesia.
References
- ↑ Schmoldt A, Benthe HF, Haberland G, Durham BH, Chiu FT, Tsui FP, Zon G (September 1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. doi:10.1021/jm00193a010. PMID 10.