Renal agenesis pathophysiology: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
* [[Kidney|Renal]] development (interactions between the [[ureteric bud]] ([[Wolffian duct|mesonephric duct]]) and the metanephric mesenchyme) starts at the 5th week of [[gestation]]. | * [[Kidney|Renal]] development (interactions between the [[ureteric bud]] ([[Wolffian duct|mesonephric duct]]) and the metanephric mesenchyme) starts at the 5th week of [[gestation]].<ref name="pmid17878895">{{cite journal| author=Schedl A| title=Renal abnormalities and their developmental origin. | journal=Nat Rev Genet | year= 2007 | volume= 8 | issue= 10 | pages= 791-802 | pmid=17878895 | doi=10.1038/nrg2205 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17878895 }} </ref> | ||
* Renal agenesis results from: | * Renal agenesis results from:<ref name="pmid18446149">{{cite journal| author=Kerecuk L, Schreuder MF, Woolf AS| title=Renal tract malformations: perspectives for nephrologists. | journal=Nat Clin Pract Nephrol | year= 2008 | volume= 4 | issue= 6 | pages= 312-25 | pmid=18446149 | doi=10.1038/ncpneph0807 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18446149 }} </ref> | ||
** Failure of the [[ureteric bud]] to form the [[ureter]], [[renal pelvis]] and the [[collecting duct system]] | ** Failure of the [[ureteric bud]] to form the [[ureter]], [[renal pelvis]] and the [[collecting duct system]] | ||
** Failure of the renal [[mesenchyme]] to form [[Nephron|nephrons]] | ** Failure of the renal [[mesenchyme]] to form [[Nephron|nephrons]] | ||
* Renal agenesis is a [[Congenital disorder|congenital]] condition caused by complete failure of [[Embryo|embryonic]] kidney formation. | * Renal agenesis is a [[Congenital disorder|congenital]] condition caused by the complete failure of [[Embryo|embryonic]] kidney formation.<ref name="pmid28722320">{{cite journal| author=Laurichesse Delmas H, Kohler M, Doray B, Lémery D, Francannet C, Quistrebert J | display-authors=etal| title=Congenital unilateral renal agenesis: Prevalence, prenatal diagnosis, associated anomalies. Data from two birth-defect registries. | journal=Birth Defects Res | year= 2017 | volume= 109 | issue= 15 | pages= 1204-1211 | pmid=28722320 | doi=10.1002/bdr2.1065 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28722320 }} </ref> | ||
* Unilateral renal agenesis (URA) is the one-sided [[Congenital disorder|congenital]] failure of [[Embryo|embryonic]] kidney formation | * Unilateral renal agenesis (URA) is the one-sided [[Congenital disorder|congenital]] failure of [[Embryo|embryonic]] kidney formation.<ref name="pmid8540439">{{cite journal| author=Robson WL, Leung AK, Rogers RC| title=Unilateral renal agenesis. | journal=Adv Pediatr | year= 1995 | volume= 42 | issue= | pages= 575-92 | pmid=8540439 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8540439 }} </ref><ref name="pmid16956352">{{cite journal| author=Woolf AS, Hillman KA| title=Unilateral renal agenesis and the congenital solitary functioning kidney: developmental, genetic and clinical perspectives. | journal=BJU Int | year= 2007 | volume= 99 | issue= 1 | pages= 17-21 | pmid=16956352 | doi=10.1111/j.1464-410X.2006.06504.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16956352 }} </ref> | ||
==References== | ==References== | ||
Revision as of 15:25, 30 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shakiba Hassanzadeh, MD[2]
Overview
Renal agenesis results from the failure of the ureteric bud to form the ureter, renal pelvis and the collecting duct system and the failure of the renal mesenchyme to form nephrons.
Pathophysiology
- Renal development (interactions between the ureteric bud (mesonephric duct) and the metanephric mesenchyme) starts at the 5th week of gestation.[1]
- Renal agenesis results from:[2]
- Failure of the ureteric bud to form the ureter, renal pelvis and the collecting duct system
- Failure of the renal mesenchyme to form nephrons
- Renal agenesis is a congenital condition caused by the complete failure of embryonic kidney formation.[3]
- Unilateral renal agenesis (URA) is the one-sided congenital failure of embryonic kidney formation.[4][5]
References
- ↑ Schedl A (2007). "Renal abnormalities and their developmental origin". Nat Rev Genet. 8 (10): 791–802. doi:10.1038/nrg2205. PMID 17878895.
- ↑ Kerecuk L, Schreuder MF, Woolf AS (2008). "Renal tract malformations: perspectives for nephrologists". Nat Clin Pract Nephrol. 4 (6): 312–25. doi:10.1038/ncpneph0807. PMID 18446149.
- ↑ Laurichesse Delmas H, Kohler M, Doray B, Lémery D, Francannet C, Quistrebert J; et al. (2017). "Congenital unilateral renal agenesis: Prevalence, prenatal diagnosis, associated anomalies. Data from two birth-defect registries". Birth Defects Res. 109 (15): 1204–1211. doi:10.1002/bdr2.1065. PMID 28722320.
- ↑ Robson WL, Leung AK, Rogers RC (1995). "Unilateral renal agenesis". Adv Pediatr. 42: 575–92. PMID 8540439.
- ↑ Woolf AS, Hillman KA (2007). "Unilateral renal agenesis and the congenital solitary functioning kidney: developmental, genetic and clinical perspectives". BJU Int. 99 (1): 17–21. doi:10.1111/j.1464-410X.2006.06504.x. PMID 16956352.