Narcolepsy historical perspective: Difference between revisions
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*[[Canine]] narcolepsy in various breeds of dogs was identified and described in 1973, by Knecht and Mitler.<ref name="pmid4736237">{{cite journal| author=Knecht CD, Oliver JE, Redding R, Selcer R, Johnson G| title=Narcolepsy in a dog and a cat. | journal=J Am Vet Med Assoc | year= 1973 | volume= 162 | issue= 12 | pages= 1052-3 | pmid=4736237 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4736237 }} </ref><ref name="pmid4472992">{{cite journal| author=Mitler MM, Boysen BG, Campbell L, Dement WC| title=Narcolepsy-cataplexy in a female dog. | journal=Exp Neurol | year= 1974 | volume= 45 | issue= 2 | pages= 332-40 | pmid=4472992 | doi=10.1016/0014-4886(74)90122-8 | pmc=2391078 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4472992 }} </ref> | *[[Canine]] narcolepsy in various breeds of dogs was identified and described in 1973, by Knecht and Mitler.<ref name="pmid4736237">{{cite journal| author=Knecht CD, Oliver JE, Redding R, Selcer R, Johnson G| title=Narcolepsy in a dog and a cat. | journal=J Am Vet Med Assoc | year= 1973 | volume= 162 | issue= 12 | pages= 1052-3 | pmid=4736237 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4736237 }} </ref><ref name="pmid4472992">{{cite journal| author=Mitler MM, Boysen BG, Campbell L, Dement WC| title=Narcolepsy-cataplexy in a female dog. | journal=Exp Neurol | year= 1974 | volume= 45 | issue= 2 | pages= 332-40 | pmid=4472992 | doi=10.1016/0014-4886(74)90122-8 | pmc=2391078 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4472992 }} </ref> | ||
*Dr. Honda (1981), together with Drs. Asaka and Juji, initiated a [[research]] study on narcolepsy and observed a significant increase in the [[frequency]] of [[HLA-B35]] in [[patients]] with narcolepsy, which lead to [[Discovery system|discovery]] in 1983 that all [[patients]] with narcolepsy were [[HLA-DR2]] positive, while only 30% [[healthy]] [[Control group|controls]] had similar [[HLA-DR2]].<ref>Honda Y, Asake A, Tanaka Y, Juji T. Discrimination of narcolepsy by using genetic markers and HLA. Sleep Res.,1 2: 254, 1983.</ref><ref>Honda Y. Introduction to " HLA in Narcolepsy". 1-10. In: Honda Y, Juji T (Eds.). HLA in Narcolepsy. 1988.</ref><ref name="pmid6597978">{{cite journal| author=Juji T, Satake M, Honda Y, Doi Y| title=HLA antigens in Japanese patients with narcolepsy. All the patients were DR2 positive. | journal=Tissue Antigens | year= 1984 | volume= 24 | issue= 5 | pages= 316-9 | pmid=6597978 | doi=10.1111/j.1399-0039.1984.tb02144.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6597978 }} </ref><ref name="MatsukiHonda1988">{{cite journal|last1=Matsuki|first1=K.|last2=Honda|first2=Y.|last3=Satake|first3=M.|last4=Juji|first4=T.|title=HLA in Narcolepsy in Japan|year=1988|pages=58–75|doi=10.1007/978-3-642-83387-8_4}}</ref> This discovery was subsequently confirmed in [[research]] studies conducted by Langdon N (1984), Billiard M (1985), Mueller-Eckhardt G (1986), and Poirier G (1986).<ref name="Mueller-EckhardtMeier-Ewert2008">{{cite journal|last1=Mueller-Eckhardt|first1=Gertrud|last2=Meier-Ewert|first2=K.|last3=Schendel|first3=Dolores J.|last4=Reinecker|first4=F. B.|last5=Multhoff|first5=Gabriele|last6=Mueller-Eckhardt|first6=C.|title=HLA and narcolepsy in a German population|journal=Tissue Antigens|volume=28|issue=3|year=2008|pages=163–169|issn=00012815|doi=10.1111/j.1399-0039.1986.tb00476.x}}</ref><ref name="LangdonDam1984">{{cite journal|last1=Langdon|first1=Nicola|last2=Dam|first2=MiekeVan|last3=Welsh|first3=KenI.|last4=Vaughan|first4=RobertW.|last5=Parkes|first5=David|title=GENETIC MARKERS IN NARCOLEPSY|journal=The Lancet|volume=324|issue=8413|year=1984|pages=1178–1180|issn=01406736|doi=10.1016/S0140-6736(84)92742-9}}</ref><ref name="pmid2857308">{{cite journal| author=| title=Extraordinary association between HLA-DR2 and narcolepsy. | journal=Lancet | year= 1985 | volume= 1 | issue= 8422 | pages= 226-7 | pmid=2857308 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2857308 }} </ref><ref name="pmid3486443">{{cite journal| author=Poirier G, Montplaisir J, Décary F, Momège D, Lebrun A| title=HLA antigens in narcolepsy and idiopathic central nervous system hypersomnolence. | journal=Sleep | year= 1986 | volume= 9 | issue= 1 Pt 2 | pages= 153-8 | pmid=3486443 | doi=10.1093/sleep/9.1.153 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3486443 }} </ref> | *Dr. Honda (1981), together with Drs. Asaka and Juji, initiated a [[research]] study on narcolepsy and observed a significant increase in the [[frequency]] of [[HLA-B35]] in [[patients]] with narcolepsy, which lead to [[Discovery system|discovery]] in 1983 that all [[patients]] with narcolepsy were [[HLA-DR2]] positive, while only 30% [[healthy]] [[Control group|controls]] had similar [[HLA-DR2]].<ref>Honda Y, Asake A, Tanaka Y, Juji T. Discrimination of narcolepsy by using genetic markers and HLA. Sleep Res.,1 2: 254, 1983.</ref><ref>Honda Y. Introduction to " HLA in Narcolepsy". 1-10. In: Honda Y, Juji T (Eds.). HLA in Narcolepsy. 1988.</ref><ref name="pmid6597978">{{cite journal| author=Juji T, Satake M, Honda Y, Doi Y| title=HLA antigens in Japanese patients with narcolepsy. All the patients were DR2 positive. | journal=Tissue Antigens | year= 1984 | volume= 24 | issue= 5 | pages= 316-9 | pmid=6597978 | doi=10.1111/j.1399-0039.1984.tb02144.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6597978 }} </ref><ref name="MatsukiHonda1988">{{cite journal|last1=Matsuki|first1=K.|last2=Honda|first2=Y.|last3=Satake|first3=M.|last4=Juji|first4=T.|title=HLA in Narcolepsy in Japan|year=1988|pages=58–75|doi=10.1007/978-3-642-83387-8_4}}</ref> This discovery was subsequently confirmed in [[research]] studies conducted by Langdon N (1984), Billiard M (1985), Mueller-Eckhardt G (1986), and Poirier G (1986).<ref name="Mueller-EckhardtMeier-Ewert2008">{{cite journal|last1=Mueller-Eckhardt|first1=Gertrud|last2=Meier-Ewert|first2=K.|last3=Schendel|first3=Dolores J.|last4=Reinecker|first4=F. B.|last5=Multhoff|first5=Gabriele|last6=Mueller-Eckhardt|first6=C.|title=HLA and narcolepsy in a German population|journal=Tissue Antigens|volume=28|issue=3|year=2008|pages=163–169|issn=00012815|doi=10.1111/j.1399-0039.1986.tb00476.x}}</ref><ref name="LangdonDam1984">{{cite journal|last1=Langdon|first1=Nicola|last2=Dam|first2=MiekeVan|last3=Welsh|first3=KenI.|last4=Vaughan|first4=RobertW.|last5=Parkes|first5=David|title=GENETIC MARKERS IN NARCOLEPSY|journal=The Lancet|volume=324|issue=8413|year=1984|pages=1178–1180|issn=01406736|doi=10.1016/S0140-6736(84)92742-9}}</ref><ref name="pmid2857308">{{cite journal| author=| title=Extraordinary association between HLA-DR2 and narcolepsy. | journal=Lancet | year= 1985 | volume= 1 | issue= 8422 | pages= 226-7 | pmid=2857308 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2857308 }} </ref><ref name="pmid3486443">{{cite journal| author=Poirier G, Montplaisir J, Décary F, Momège D, Lebrun A| title=HLA antigens in narcolepsy and idiopathic central nervous system hypersomnolence. | journal=Sleep | year= 1986 | volume= 9 | issue= 1 Pt 2 | pages= 153-8 | pmid=3486443 | doi=10.1093/sleep/9.1.153 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3486443 }} </ref> | ||
*Link with the [[HLA-DQB1]]*0602 [[gene]] on [[chromosome]] 6 was established in 1980s. As many [[HLA]] associated [[disorders]] are also [[autoimmune]] in nature, it raised the possibility that narcolepsy may be an [[Autoimmune disease|autoimmune disorder]].<ref name="CarlanderEliaou1993">{{cite journal|last1=Carlander|first1=B|last2=Eliaou|first2=JF|last3=Billiard|first3=M|title=Autoimmune hypothesis in narcolepsy|journal=Neurophysiologie Clinique/Clinical Neurophysiology|volume=23|issue=1|year=1993|pages=15–22|issn=09877053|doi=10.1016/S0987-7053(05)80279-5}}</ref><ref name="MignotTafti1995">{{cite journal|last1=Mignot|first1=Emmanuel|last2=Tafti|first2=Mehdi|last3=Dement|first3=William C.|last4=Grumet|first4=F.Carl|title=Narcolepsy and immunity|journal=Advances in Neuroimmunology|volume=5|issue=1|year=1995|pages=23–37|issn=09605428|doi=10.1016/0960-5428(94)00043-N}}</ref><ref name="pmid3080168">{{cite journal| author=Parkes JD, Langdon N, Lock C| title=Narcolepsy and immunity. | journal=Br Med J (Clin Res Ed) | year= 1986 | volume= 292 | issue= 6517 | pages= 359-60 | pmid=3080168 | doi=10.1136/bmj.292.6517.359 | pmc=1339341 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3080168 }} </ref> | *Link with the [[HLA-DQB1]]*0602 [[gene]] on [[chromosome]] 6 was established in 1980s.<ref name="MatsukiGrumet1992">{{cite journal|last1=Matsuki|first1=Kazumasa|last2=Grumet|first2=F.Carl|last3=Lin|first3=Xiaoyan|last4=Gelb|first4=Michael|last5=Guilleminault|first5=Christian|last6=Dement|first6=WilliamC.|last7=Mignot|first7=Emmanuel|title=DQ (rather than DR) gene marks susceptibility to narcolepsy|journal=The Lancet|volume=339|issue=8800|year=1992|pages=1052|issn=01406736|doi=10.1016/0140-6736(92)90571-J}}</ref><ref name="MignotKimura1997">{{cite journal|last1=Mignot|first1=E.|last2=Kimura|first2=A.|last3=Lattermann|first3=A.|last4=Lin|first4=X.|last5=Yasunaga|first5=S.|last6=Mueller-Eckhardt|first6=G.|last7=Rattazzi|first7=C.|last8=Lin|first8=L.|last9=Guilleminault|first9=C.|last10=Grumet|first10=F. C.|last11=Mayer|first11=G.|last12=Dement|first12=W. C.|last13=Underhill|first13=P.|title=Extensive HLA class II studies in 58 non-DRB1*15 (DR2) narcoleptic patients with cataplexy|journal=Tissue Antigens|volume=49|issue=4|year=1997|pages=329–341|issn=00012815|doi=10.1111/j.1399-0039.1997.tb02761.x}}</ref><ref name="MignotLin1994">{{cite journal|last1=Mignot|first1=E.|last2=Lin|first2=X.|last3=Arrigoni|first3=J.|last4=Macaubas|first4=C.|last5=Olive|first5=F.|last6=Hallmayer|first6=J.|last7=Underhill|first7=P.|last8=Guilleminault|first8=C.|last9=Dement|first9=W. C.|last10=Grumet|first10=F. C.|title=DQB1*0602 and DQA1*0102 (DQ1) Are Better Markers Than DR2 for Narcolepsy in Caucasian and Black Americans|journal=Sleep|volume=17|issue=suppl_8|year=1994|pages=S60–S67|issn=1550-9109|doi=10.1093/sleep/17.suppl_8.S60}}</ref> As many [[HLA]] associated [[disorders]] are also [[autoimmune]] in nature, it raised the possibility that narcolepsy may be an [[Autoimmune disease|autoimmune disorder]].<ref name="CarlanderEliaou1993">{{cite journal|last1=Carlander|first1=B|last2=Eliaou|first2=JF|last3=Billiard|first3=M|title=Autoimmune hypothesis in narcolepsy|journal=Neurophysiologie Clinique/Clinical Neurophysiology|volume=23|issue=1|year=1993|pages=15–22|issn=09877053|doi=10.1016/S0987-7053(05)80279-5}}</ref><ref name="MignotTafti1995">{{cite journal|last1=Mignot|first1=Emmanuel|last2=Tafti|first2=Mehdi|last3=Dement|first3=William C.|last4=Grumet|first4=F.Carl|title=Narcolepsy and immunity|journal=Advances in Neuroimmunology|volume=5|issue=1|year=1995|pages=23–37|issn=09605428|doi=10.1016/0960-5428(94)00043-N}}</ref><ref name="pmid3080168">{{cite journal| author=Parkes JD, Langdon N, Lock C| title=Narcolepsy and immunity. | journal=Br Med J (Clin Res Ed) | year= 1986 | volume= 292 | issue= 6517 | pages= 359-60 | pmid=3080168 | doi=10.1136/bmj.292.6517.359 | pmc=1339341 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3080168 }} </ref> | ||
*[[Hypocretin]]<nowiki/>s ([[orexins]]) were identified in 1990s. In 1998, DeLecea and Sakurai identified [[hypocretin]]<nowiki/>s/[[orexins]] almost simultaneously with a difference of a few weeks. | *[[Hypocretin]]<nowiki/>s ([[orexins]]) were identified in 1990s. In 1998, DeLecea and Sakurai identified [[hypocretin]]<nowiki/>s/[[orexins]] almost simultaneously with a difference of a few weeks. | ||
*[[Hypocretin]] [[deficiency]] was associated with [[human]] narcolepsy by Nishino and Ripley in 2000. | *[[Hypocretin]] [[deficiency]] was associated with [[human]] narcolepsy by Nishino and Ripley in 2000. |
Revision as of 09:49, 10 August 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Muhammad Waleed Haider, M.D.[2]
Overview
Historical Perspective
Discovery
- The earliest account of narcolepsy was described by Thomas Willis (1621-1675) in patients, "with a sleepy disposition who suddenly falls fast asleep."
- The term narcolepsy is derived by combining the Greek narke numbness, stupor and lepsis attack, to seize.
- The first-ever convincing descriptions of narcolepsy and cataplexy were reported by Westphal (1877) and Fisher (1878) in Germany.[1][2] Both descriptions observed a hereditary factor in narcolepsy; the mother of Westphal's patient and a sister of Fisher's patient had similar clinical features. They also reported the unique association of excitement and sleepiness triggering episodes of muscle weakness.
- French physician Jean-Baptiste-Édouard Gélineau (1880) described this condition in a wine merchant as neurosis or a functional condition.[3] Gélineau gave narcolepsy its name, which is the English form of the French word narcolepsie, and recognized narcolepsy as a specific clinical entity.[4][5][6] Although Gélineau named this distinct clinical entity he did not differentiate episodes of muscle weakness and sleep attacks triggered by emotions as he proposed common physiology for these two distinct symptoms of narcolepsy.
- Cataplexy from the Greek kataplexis (fixation of the eyes), was first named by Loëwenfeld (1902) as he was the first to name brief episodes of muscle weakness triggered by emotions.[7]
- Kinnier Wilson (1928) first coined the term, "sleep paralysis."
- Large case series of narcolepsy with cataplexy was published by Addie (1926), Wilson (1927), and Daniels (1934).[8][9][10] Review of narcolepsy-cataplexy by Daniels is considered by many as one of the most insightful clinical reviews published.
- Various causes or lesions were proposed for narcolepsy. Tumors situated in relation to the third ventricle were suggested as a possible cause of narcolepsy by Wilson. The association of oculomotor paralysis and somnolence led to the pioneering work of Von Economo (1930) who first recognized the posterior hypothalamus as a critical region for the promotion of wakefulness and correctly proposed that a region in the posterior hypothalamus was lesioned in human narcolepsy.[11] He specifically wrote: “it is very probable, though not proved, that the narcolepsy of Redlich, Westphal, and Gélineau has its primary cause in a yet unknown disease of that region”.
- The classic description of narcolepsy tetrad was possible due to further work by Yoss and Daly at the Mayo clinic in 1957 and Bedrich Roth in Prague.[12][13]
- REM sleep at the onset of sleep attack in narcoleptic patients was first ever recorded and reported by Vogel (1960), an observation extended by Rechschaffen and Dement in 1967.[14][15] Hishikawa (1968) studied the EEG of narcoleptic patients.[16] These authors together first articulated the now classical hypothesis of dissociated REM sleep and explained some symptoms of narcolepsy. Their discovery established a multiple sleep latency test as a standard diagnostic test for narcolepsy in 1970.[17][18]
- The first epidemiological studies of narcolepsy were performed by Roth (1980) and Dement (1972-73), revealing a prevalence of 0.02-0.05% for narcolepsy with cataplexy. [19][20][21]
- Canine narcolepsy in various breeds of dogs was identified and described in 1973, by Knecht and Mitler.[22][23]
- Dr. Honda (1981), together with Drs. Asaka and Juji, initiated a research study on narcolepsy and observed a significant increase in the frequency of HLA-B35 in patients with narcolepsy, which lead to discovery in 1983 that all patients with narcolepsy were HLA-DR2 positive, while only 30% healthy controls had similar HLA-DR2.[24][25][26][27] This discovery was subsequently confirmed in research studies conducted by Langdon N (1984), Billiard M (1985), Mueller-Eckhardt G (1986), and Poirier G (1986).[28][29][30][31]
- Link with the HLA-DQB1*0602 gene on chromosome 6 was established in 1980s.[32][33][34] As many HLA associated disorders are also autoimmune in nature, it raised the possibility that narcolepsy may be an autoimmune disorder.[35][36][37]
- Hypocretins (orexins) were identified in 1990s. In 1998, DeLecea and Sakurai identified hypocretins/orexins almost simultaneously with a difference of a few weeks.
- Hypocretin deficiency was associated with human narcolepsy by Nishino and Ripley in 2000.
Landmark Events in the Development of Treatment Strategies
- Various methods were initially proposed in the treatment of narcolepsy until Prinzmetal and Bloomberg introduced amphetamines in 1935.[38]
- After the discovery of tricyclic antidepressants in 1957, Akimoto, Honda, and Takahashi used imipramine in the treatment of cataplexy in humans.[39]
- Methylphenidate was introduced by Yoss and Daly in the 1960s.[40]
Impact on Cultural History
Famous Cases
The following are a few famous cases of [disease name]:
References
- ↑ Fischer, Franz (1878). "Epileptoide Schlafzustände". Archiv für Psychiatrie und Nervenkrankheiten. 8 (1): 200–203. doi:10.1007/BF01791317. ISSN 0003-9373.
- ↑ Westphal C. Eigenthümliche mit Einschläfen verbundene Anfälle. Arch. Psychiat., 7: 631-635 1877.
- ↑ Schenck CH, Bassetti CL, Arnulf I, Mignot E (2007). "English translations of the first clinical reports on narcolepsy and cataplexy by Westphal and Gélineau in the late 19th century, with commentary". J Clin Sleep Med. 3 (3): 301–11. PMC 2564780. PMID 17561602.
- ↑ Janković S, Susić V, Sokić D, Lević Z (1996). "[Dr. John Baptiste Edouard Gélineau]". Srp Arh Celok Lek. 124 (11–12): 331–5. PMID 9132972.
- ↑ Gélineau J. De la narcolepsie. Gazette des hôpitaux,. 53: 626-628, 1880.
- ↑ Gélineau JBE. De la narcolepsie. Surgères, Charente-Inférieure: Imprimerie de Surgères, 64, 1881.
- ↑ Löwenfeld L. Uber Narkolepsie. Munch. Med. Wochenschr., 49: 1041-1045, 1902.
- ↑ Addie W. IdIopathic narcolepsy: a disease sui generis; with remarks on the mechanism of sleep. Brain, 49: 257-306, 1926.
- ↑ Wilson SAK. The narcolepsies. Annual Congress Assoc. Phys., June 3: 63-109, 1927.
- ↑ Daniels LE. Narcolepsy. Medicine, 13(1): 1-122, 1934.
- ↑ Van Economo C. Sleep as a problem of localization. J. Nerv. Ment. Disease, 71(3): 249-259, 1930.
- ↑ . doi:10.1159/isbn.978-3-318-05312-8. Missing or empty
|title=
(help) - ↑ YOSS RE, DALY DD (1957). "Criteria for the diagnosis of the narcoleptic syndrome". Proc Staff Meet Mayo Clin. 32 (12): 320–8. PMID 13441766.
- ↑ Vogel, Gerald (1960). "Studies in Psychophysiology of Dreams". Archives of General Psychiatry. 3 (4): 421. doi:10.1001/archpsyc.1960.01710040091011. ISSN 0003-990X.
- ↑ Rechtschaffen A, Dement W (1967). "Studies on the relation of narcolepsy, cataplexy, and sleep with low voltage random EEG activity". Res Publ Assoc Res Nerv Ment Dis. 45: 488–505. PMID 6083200.
- ↑ Hishikawa Y, Nan'no H, Tachibana M, Furuya E, Koida H, Kaneko Z (1968). "The nature of sleep attack and other symptoms of narcolepsy". Electroencephalogr Clin Neurophysiol. 24 (1): 1–10. doi:10.1016/0013-4694(68)90060-6. PMID 4169745.
- ↑ Richardson GS, Carskadon MA, Flagg W, Van den Hoed J, Dement WC, Mitler MM (1978). "Excessive daytime sleepiness in man: multiple sleep latency measurement in narcoleptic and control subjects". Electroencephalogr Clin Neurophysiol. 45 (5): 621–7. doi:10.1016/0013-4694(78)90162-1. PMC 2391074. PMID 81764.
- ↑ Carskadon MA, Dement WC, Mitler MM, Roth T, Westbrook PR, Keenan S (1986). "Guidelines for the multiple sleep latency test (MSLT): a standard measure of sleepiness". Sleep. 9 (4): 519–24. doi:10.1093/sleep/9.4.519. PMID 3809866.
- ↑ Roth, Bedrich, and Roger J. Broughton. Narcolepsy and hypersomnia. Basel New York: Karger, 1980. Print.
- ↑ Dement WC, Zarcone V, Varner V. The prevalence of narcolepsy. Sleep Res., 1: 148-149 1972.
- ↑ Dement WC, Carskadon M, Ley R. The prevalence of narcolepsy II. Sleep Res., 2: 147, 1973.
- ↑ Knecht CD, Oliver JE, Redding R, Selcer R, Johnson G (1973). "Narcolepsy in a dog and a cat". J Am Vet Med Assoc. 162 (12): 1052–3. PMID 4736237.
- ↑ Mitler MM, Boysen BG, Campbell L, Dement WC (1974). "Narcolepsy-cataplexy in a female dog". Exp Neurol. 45 (2): 332–40. doi:10.1016/0014-4886(74)90122-8. PMC 2391078. PMID 4472992.
- ↑ Honda Y, Asake A, Tanaka Y, Juji T. Discrimination of narcolepsy by using genetic markers and HLA. Sleep Res.,1 2: 254, 1983.
- ↑ Honda Y. Introduction to " HLA in Narcolepsy". 1-10. In: Honda Y, Juji T (Eds.). HLA in Narcolepsy. 1988.
- ↑ Juji T, Satake M, Honda Y, Doi Y (1984). "HLA antigens in Japanese patients with narcolepsy. All the patients were DR2 positive". Tissue Antigens. 24 (5): 316–9. doi:10.1111/j.1399-0039.1984.tb02144.x. PMID 6597978.
- ↑ Matsuki, K.; Honda, Y.; Satake, M.; Juji, T. (1988). "HLA in Narcolepsy in Japan": 58–75. doi:10.1007/978-3-642-83387-8_4.
- ↑ Mueller-Eckhardt, Gertrud; Meier-Ewert, K.; Schendel, Dolores J.; Reinecker, F. B.; Multhoff, Gabriele; Mueller-Eckhardt, C. (2008). "HLA and narcolepsy in a German population". Tissue Antigens. 28 (3): 163–169. doi:10.1111/j.1399-0039.1986.tb00476.x. ISSN 0001-2815.
- ↑ Langdon, Nicola; Dam, MiekeVan; Welsh, KenI.; Vaughan, RobertW.; Parkes, David (1984). "GENETIC MARKERS IN NARCOLEPSY". The Lancet. 324 (8413): 1178–1180. doi:10.1016/S0140-6736(84)92742-9. ISSN 0140-6736.
- ↑ "Extraordinary association between HLA-DR2 and narcolepsy". Lancet. 1 (8422): 226–7. 1985. PMID 2857308.
- ↑ Poirier G, Montplaisir J, Décary F, Momège D, Lebrun A (1986). "HLA antigens in narcolepsy and idiopathic central nervous system hypersomnolence". Sleep. 9 (1 Pt 2): 153–8. doi:10.1093/sleep/9.1.153. PMID 3486443.
- ↑ Matsuki, Kazumasa; Grumet, F.Carl; Lin, Xiaoyan; Gelb, Michael; Guilleminault, Christian; Dement, WilliamC.; Mignot, Emmanuel (1992). "DQ (rather than DR) gene marks susceptibility to narcolepsy". The Lancet. 339 (8800): 1052. doi:10.1016/0140-6736(92)90571-J. ISSN 0140-6736.
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