Tetradecanoylphorbol-13-acetate response element gene transcriptions: Difference between revisions
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==Consensus sequences== | ==Consensus sequences== | ||
12-''O''-tetradecanoylphorbol-13-acetate (TPA) responsive element (TRE) (TGAGTCA).<ref name=Sato/> | 12-''O''-tetradecanoylphorbol-13-acetate (TPA) responsive element (TRE) (TGAGTCA).<ref name=Sato>{{ cite journal | ||
|author=Hiroshi Sato, Megumi Kita, and Motoharu Seiki | |||
|title=v-Src Activates the Expression of 92-kDa Type IV Collagenase Gene through the AP-1 Site and the GT Box Homologous to Retinoblastoma Control Elements | |||
|journal=The Journal of Biological Chemistry | |||
|date=5 November 1993 | |||
|volume=268 | |||
|issue=31 | |||
|pages=23460-8 | |||
|url=https://www.jbc.org/content/268/31/23460.full.pdf | |||
|arxiv= | |||
|bibcode= | |||
|doi= | |||
|pmid= | |||
|accessdate=13 August 2020 }}</ref> | |||
==Samplings== | ==Samplings== | ||
Revision as of 04:16, 24 August 2020
Activator protein 1 (AP-1) was first discovered as a 12-O-Tetradecanoylphorbol-13-acetate (TPA)-activated transcription factor that bound to a cis-regulatory element of the human metallothionein IIa (hMTIIa) promoter and SV40.[1] The AP-1 binding site was identified as the TPA response element (TRE) with the consensus sequence 5’-TGA G/C TCA-3’.[2]
Consensus sequences
12-O-tetradecanoylphorbol-13-acetate (TPA) responsive element (TRE) (TGAGTCA).[3]
Samplings
See also
References
- ↑ Lee W, Haslinger A, Karin M, Tjian R (January 1987). "Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40". Nature. 325 (6102): 368–72. Bibcode:1987Natur.325..368L. doi:10.1038/325368a0. PMID 3027570.
- ↑ Angel P, Imagawa M, Chiu R, Stein B, Imbra RJ, Rahmsdorf HJ, Jonat C, Herrlich P, Karin M (June 1987). "Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor". Cell. 49 (6): 729–39. doi:10.1016/0092-8674(87)90611-8. PMID 3034432.
- ↑ Hiroshi Sato, Megumi Kita, and Motoharu Seiki (5 November 1993). "v-Src Activates the Expression of 92-kDa Type IV Collagenase Gene through the AP-1 Site and the GT Box Homologous to Retinoblastoma Control Elements" (PDF). The Journal of Biological Chemistry. 268 (31): 23460–8. Retrieved 13 August 2020.