Tricuspid atresia pathophysiology: Difference between revisions
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== Classification == | == Classification == | ||
Tricuspid atresia is classified according to connection between ventricles with great arteries(aorta, pulmonary) into two subgroups: | *Tricuspid atresia is classified according to the connection between ventricles with great arteries(aorta, pulmonary) into two subgroups: | ||
* | ** Normal connection between [[ventricles]] with the [[aorta ]]and [[pulmonary artery]]. It is a common type that is consistent with 70%-80% of cases. Most patients are[[ cyanotic]]. | ||
* Aorta originated from small | ** [[Aorta]] originated from small [[right ventricle]] and the[[ pulmonary artery ]]comes from the[[ left ventricle]]. [[Heart failure]] and [[pulmonary hypertension ]]are common and patients are not[[ cyanotic]]. Flow in the aorta is dependent on [[ventricular setrum defect]](VSD) size. [[Subaortic stenosis]] and [[aortic arch]] anomalies are common. | ||
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Revision as of 14:01, 24 August 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Sara Zand, M.D.[2] Keri Shafer, M.D. [3] Priyamvada Singh, MBBS [4]; Assistant Editor-In-Chief: Kristin Feeney, B.S. [5]
Historical perspective
- Tricuspid atresia was first discovered by Friedrich Ludwig kreysig in 1817, a German physician who found the obstruction between the right atrium and right ventricle in the autopsy of cyanotic infants.
- The classic term of tricuspid atresia was used firstly by schuberg in 1861.
Pathophysiology
Normal Human Heart
Tricuspid Atresia
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- Tricuspid atresia occurs during prenatal development.
- In tricuspid atresia, there is no continuity between the right atrium and right ventricle.
- Inferior vena cava and superior vena cava collect venous nonoxygenated blood into the right atrium.
- Through atrial septal defect (ASD)blood reaches into the left atrium, then left ventricle andaorta.
- This blood is a mixture of saturated and unsaturated O2.
- If there is a ventricular septal defect (VSD), this mixed blood in the left ventricle flows into the right ventricle, then via pulmonary artery reaches pulmonary bed and becomes oxygenated, then returns back into the left atrium viapulmonary veins.
- In diminished pulmonary blood flow whether the flow is dependent on patent ductus arteriosus (PDA), the mixed-blood in aorta flows from this passage intopulmonary artery and pulmonary bed.
- In the presence of normal positioning of great arteries, cyanosis is more prominent and is affected by the size ofVSD.
- Transpositioning great arteries (TGA) and subaortic stenosis are other associated anomalies.
Classification
- Tricuspid atresia is classified according to the connection between ventricles with great arteries(aorta, pulmonary) into two subgroups:
- Normal connection between ventricles with the aorta and pulmonary artery. It is a common type that is consistent with 70%-80% of cases. Most patients arecyanotic.
- Aorta originated from small right ventricle and thepulmonary artery comes from theleft ventricle. Heart failure and pulmonary hypertension are common and patients are notcyanotic. Flow in the aorta is dependent on ventricular setrum defect(VSD) size. Subaortic stenosis and aortic arch anomalies are common.