Sandbox:Hanan Elkalawy

Historical perspective

Pathophysiology

Cause

• CVS
• CNS
  • Parkinson
    • Tremor
• Respiratory

aaaa	aaaaa
'	Erythema gyratum repens is associated with internal malignancy in 82% of cases The most common neoplasms are Lung/bronchogenic, breast cancer, and GI tract (stomach, esophageal) cancer. The other associated neoplasms are: Urinary bladder, prostate, uterine and/or cervix, and anal cancer
Non-paraneoplastic EGR	Idiopathic EGR
Erythema gyratum repens with no underlying malignancy, associated conditions, or precipitating cause
|EGR-like eruptions
Can appear in various autoimmune conditions Characterized by annular lesions with expanding concentric pattern and coalescing to form a zebra-like pattern or grain of wood pattern EGR-like eruption in Sjögren syndrome (SS) is extremely rare
EGR with concomitant skin disease
Pityriasis rubra pilaris, psoriasis, ichthyosis, CREST (calcinosis, Raynaud phenomenon, esophageal motility disorder, sclerodactyly, and telangiectasia) syndrome, virginal breast hypertrophy, rheumatoid arthritis, tuberculosis, bullous pemphigoid, linear IgA disease, and hypereosinophilic syndrome, cryptogenic organizing pneumonia
Drug-induced EGR
Azathioprine with type I autoimmune hepatitis Interferon given for hepatitis C virus–related chronic hepatitis

Table2

Variant	Associated mutation