Lymphadenopathy diagnostic criteria

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2]Delband Yekta Moazami, M.D.[3]

Overview

Diagnostic criteria for malignant lymphadenopathy may include: the size of node more than 2 cm, a node that is draining, hard, or fixed to underlying tissue, atypical location (e.g. supraclavicular node), associated risk factors (e.g. HIV or TB), fever, and/or weight loss, and splenomegaly. On the other hand, diagnostic criteria for benign lymphadenopathy may include: node smaller than 1 cm, a node that is mobile, soft-or tender, and is not fixed to underlying tissue, typical location (e.g. supraclavicular node), no associated risk factors, and palpable and painful enlargement.

Diagnostic Criteria

Malignant Lymphadenopathy

• Node > 2 cm
• Node that is draining, hard, or fixed to underlying tissue
• Atypical location (e.g. supraclavicular node)
• Risk factors (e.g. HIV or TB)
• Fever and/or weight loss
• Splenomegaly

Benign Lymphadenopathy

• Node < 1 cm
• Node that is mobile, soft-or tender, and is not fixed to underlying tissue
• Common location (e.g. supraclavicular node)
• No associated risk factors
• Palpable and painful enlargement