Immune Thrombocytopenia pathophysiology: Difference between revisions
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Genes involved in the pathogenesis of | Genes involved in the pathogenesis of immune thrombocytopenia include: | ||
*[ | *[[Transmembrane protein|Transmembrane]] [[mucin]], MUC3A. ([[Missense mutation|missense]] [[mutation]]) | ||
*[ | *[[Secretory protein|Secretory]] [[mucin]], MUC5B. ( missense mutation) | ||
*[ | *Secretory mucin, MUC6. (missense mutation) <ref name="ZhuYuan2020">{{cite journal|last1=Zhu|first1=Jing-jing|last2=Yuan|first2=Dai|last3=Sun|first3=Rui-Jie|last4=Liu|first4=Shu-yan|last5=Shan|first5=Ning-ning|title=Mucin mutations and aberrant expression are associated with the pathogenesis of immune thrombocytopenia|journal=Thrombosis Research|volume=194|year=2020|pages=222–228|issn=00493848|doi=10.1016/j.thromres.2020.08.005}}</ref> | ||
*Fc<math>\gamma</math>R [[polymorphism]].<ref name="Johnsen2012">{{cite journal|last1=Johnsen|first1=Jill|title=Pathogenesis in immune thrombocytopenia: new insights|journal=Hematology|volume=2012|issue=1|year=2012|pages=306–312|issn=1520-4391|doi=10.1182/asheducation.V2012.1.306.3798320}}</ref> | |||
*IKZF1 [[haploinsufficiency]] ( [[hematopoietic]] [[zinc finger]] [[transcription factor]] which directly binds to [[DNA]]. presents in familial immune thrombocytopenia.)<ref name="SriaroonChang2019">{{cite journal|last1=Sriaroon|first1=Panida|last2=Chang|first2=Yenhui|last3=Ujhazi|first3=Boglarka|last4=Csomos|first4=Krisztian|last5=Joshi|first5=Hemant R.|last6=Zhou|first6=Qin|last7=Close|first7=Devin W.|last8=Walter|first8=Jolan E.|last9=Kumánovics|first9=Attila|title=Familial Immune Thrombocytopenia Associated With a Novel Variant in IKZF1|journal=Frontiers in Pediatrics|volume=7|year=2019|issn=2296-2360|doi=10.3389/fped.2019.00139}}</ref> | |||
*HIF1 [[signaling pathway]]. | |||
*[[mTOR]] signaling pathway. | |||
*PI3K/Akt signaling pathway.<ref name="SunLiu2020">{{cite journal|last1=Sun|first1=Ruijie|last2=Liu|first2=Shu-Yan|last3=Zhang|first3=Xiao-Mei|last4=Zhu|first4=Jing-Jing|last5=Yuan|first5=Dai|last6=Shan|first6=Ning-Ning|year=2020|doi=10.21203/rs.3.rs-131436/v1}}</ref> | |||
* | |||
OR | OR | ||
Revision as of 15:18, 4 February 2021
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Immune Thrombocytopenia Microchapters |
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Diagnosis |
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Immune Thrombocytopenia pathophysiology On the Web |
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American Roentgen Ray Society Images of Immune Thrombocytopenia pathophysiology |
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Risk calculators and risk factors for Immune Thrombocytopenia pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Maryam Barkhordarian, M.D.[2]
Overview
The exact pathogenesis of [disease name] is not fully understood.
OR
It is thought that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
OR
[Pathogen name] is usually transmitted via the [transmission route] route to the human host.
OR
Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
OR
[Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
OR
The progression to [disease name] usually involves the [molecular pathway].
OR
The pathophysiology of [disease/malignancy] depends on the histological subtype.
Pathophysiology
Pathogenesis
- Immune thrombocytopenia arises from platelets, which are blood cells that are normally involved in hemostasis.
- It is understood that Immune thrombocytopenia is caused by destruction of one's own platelets and megakaryocytes.
- The progression to immune thrombocytopenia usually involves the genetic predisposition, immune dysregulation and environmental factors which lead to autoimmunity.
- Molecular mimicry between foreign antigens and autologous platelet antigens leads to activation of cross-reactive B and T cell, starting autoimmune response.[1]
Genetics
[Disease name] is transmitted in [mode of genetic transmission] pattern.
OR
Genes involved in the pathogenesis of immune thrombocytopenia include:
- Transmembrane mucin, MUC3A. (missense mutation)
- Secretory mucin, MUC5B. ( missense mutation)
- Secretory mucin, MUC6. (missense mutation) [2]
- Fc<math>\gamma</math>R polymorphism.[3]
- IKZF1 haploinsufficiency ( hematopoietic zinc finger transcription factor which directly binds to DNA. presents in familial immune thrombocytopenia.)[4]
- HIF1 signaling pathway.
- mTOR signaling pathway.
- PI3K/Akt signaling pathway.[5]
OR
The development of [disease name] is the result of multiple genetic mutations such as:
- [Mutation 1]
- [Mutation 2]
- [Mutation 3]
Associated Conditions
Conditions associated with [disease name] include:
- [Condition 1]
- [Condition 2]
- [Condition 3]
Gross Pathology
On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
Microscopic Pathology
On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
References
- ↑ Li, June; Sullivan, Jade A.; Ni, Heyu (2018). "Pathophysiology of immune thrombocytopenia". Current Opinion in Hematology. 25 (5): 373–381. doi:10.1097/MOH.0000000000000447. ISSN 1065-6251.
- ↑ Zhu, Jing-jing; Yuan, Dai; Sun, Rui-Jie; Liu, Shu-yan; Shan, Ning-ning (2020). "Mucin mutations and aberrant expression are associated with the pathogenesis of immune thrombocytopenia". Thrombosis Research. 194: 222–228. doi:10.1016/j.thromres.2020.08.005. ISSN 0049-3848.
- ↑ Johnsen, Jill (2012). "Pathogenesis in immune thrombocytopenia: new insights". Hematology. 2012 (1): 306–312. doi:10.1182/asheducation.V2012.1.306.3798320. ISSN 1520-4391.
- ↑ Sriaroon, Panida; Chang, Yenhui; Ujhazi, Boglarka; Csomos, Krisztian; Joshi, Hemant R.; Zhou, Qin; Close, Devin W.; Walter, Jolan E.; Kumánovics, Attila (2019). "Familial Immune Thrombocytopenia Associated With a Novel Variant in IKZF1". Frontiers in Pediatrics. 7. doi:10.3389/fped.2019.00139. ISSN 2296-2360.
- ↑ Sun, Ruijie; Liu, Shu-Yan; Zhang, Xiao-Mei; Zhu, Jing-Jing; Yuan, Dai; Shan, Ning-Ning (2020). doi:10.21203/rs.3.rs-131436/v1. Missing or empty
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