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===={{CMG}}; {{AE}} {{Aneeza Jamshed}}==== | ===={{CMG}}; {{AE}} {{Aneeza Jamshed}}==== | ||
=LIBMAN-SACK ENDOCARDITIS:= | |||
===OVERVIEW:=== | ===OVERVIEW:=== | ||
Libman-sack endocarditis is the one of the cardiac manifestations of autoimmune systemic diseases most commonly [[Systemic lupus erythematosus|Systemic Lupus Erythematosus]]. It may also be a finding in malignancy with the non-bacterial non-thrombotic involvement of the valves, most commonly the aortic and mitral valve. The most common complications include embolic phenomenon like cerebrovascular disease. The disease activity and titer of the antibodies in Systemic Lupus Erythematosus can be linked to Libman-sack Endocarditis<ref name="pmidPMID: 20422938">{{cite journal| author=Carrillo-Esper R, Carrillo-Córdova JR, Carrillo-Córdova LD, Carrillo-Córdova CA| title=[Libman-Sacks endocarditis]. | journal=Gac Med Mex | year= 2010 | volume= 146 | issue= 1 | pages= 67-9 | pmid=PMID: 20422938 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20422938 }} </ref>. | Libman-sack endocarditis is the one of the cardiac manifestations of autoimmune systemic diseases most commonly [[Systemic lupus erythematosus|Systemic Lupus Erythematosus]]. It may also be a finding in malignancy with the non-bacterial non-thrombotic involvement of the valves, most commonly the aortic and mitral valve. The most common complications include embolic phenomenon like cerebrovascular disease and infective endocarditis with valvular insufficeincy. The disease activity and titer of the antibodies in Systemic Lupus Erythematosus can be linked to Libman-sack Endocarditis<ref name="pmidPMID: 20422938">{{cite journal| author=Carrillo-Esper R, Carrillo-Córdova JR, Carrillo-Córdova LD, Carrillo-Córdova CA| title=[Libman-Sacks endocarditis]. | journal=Gac Med Mex | year= 2010 | volume= 146 | issue= 1 | pages= 67-9 | pmid=PMID: 20422938 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20422938 }} </ref>. | ||
= | ===HISTORICAL PERSPECTIVES:=== | ||
<ref name=" | Libman and Sack in 1924, first coined this term for the sterile verrucous vegetations of the mitral and aortic valves in patients of Systemic Lupus Erythematosus<ref name="pmidPMID: 19089657">{{cite journal| author=Lee JL, Naguwa SM, Cheema GS, Gershwin ME| title=Revisiting Libman-Sacks endocarditis: a historical review and update. | journal=Clin Rev Allergy Immunol | year= 2009 | volume= 36 | issue= 2-3 | pages= 126-30 | pmid=PMID: 19089657 | doi=10.1007/s12016-008-8113-y | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19089657 }} </ref>. | ||
<br /> | |||
=== PATHOPHYSIOLOGY: === | |||
Revision as of 12:07, 4 April 2021
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aneeza Jamshed, M.B.B.S.[2]
LIBMAN-SACK ENDOCARDITIS:
OVERVIEW:
Libman-sack endocarditis is the one of the cardiac manifestations of autoimmune systemic diseases most commonly Systemic Lupus Erythematosus. It may also be a finding in malignancy with the non-bacterial non-thrombotic involvement of the valves, most commonly the aortic and mitral valve. The most common complications include embolic phenomenon like cerebrovascular disease and infective endocarditis with valvular insufficeincy. The disease activity and titer of the antibodies in Systemic Lupus Erythematosus can be linked to Libman-sack Endocarditis[1].
HISTORICAL PERSPECTIVES:
Libman and Sack in 1924, first coined this term for the sterile verrucous vegetations of the mitral and aortic valves in patients of Systemic Lupus Erythematosus[2].
PATHOPHYSIOLOGY:
| Criteria | Symptomatic WM | Asymptomatic WM | IgM-Related Disorders | MGUS |
|---|---|---|---|---|
| IgM monoclonal protein | + | + | + | + |
| Bone marrow infiltration | + | + | - | - |
| Symptoms attributable to IgM | + | - | + | - |
| Symptoms attributable to tumor infiltration | + | - | - | - |
|
Libman-Sacks endocarditis Microchapters |
|
Differentiating Libman-Sacks Endocarditis from other Diseases |
|---|
Reference
- ↑ Carrillo-Esper R, Carrillo-Córdova JR, Carrillo-Córdova LD, Carrillo-Córdova CA (2010). "[Libman-Sacks endocarditis]". Gac Med Mex. 146 (1): 67–9. PMID 20422938 PMID: 20422938 Check
|pmid=value (help). - ↑ Lee JL, Naguwa SM, Cheema GS, Gershwin ME (2009). "Revisiting Libman-Sacks endocarditis: a historical review and update". Clin Rev Allergy Immunol. 36 (2–3): 126–30. doi:10.1007/s12016-008-8113-y. PMID 19089657 PMID: 19089657 Check
|pmid=value (help).