Clinical depression differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2]

Differential Diagnosis

Manic episodes with irritable mood or mixed episodes Substance/medication-induced depressive or bipolar disorder Attention-deficit hyperactivity disorder Adjustment disorder with depressed mood Sadness

Differential diagnosis for Major depressive disorder
Depressive disorder	Distinguishingfeature from MDD
Bipolar I or Bipolar II disorder	*One or more manic or hypomanic episodes are required for diagnosis. If manic or hypomanic episodes have ever been present, the patient cannot be diagnosed with major depressive disorder. If patients with major depressive symptoms have some manic or hypomanic symptoms that are not enough for diagnosis of mania and hypomania (i.e. fewer symptoms or shorter duration), they are specified as "major depressive symptoms with mixed features".
Depressive disorder due to another medical condition	Diagnosis of Depressive disorder due to another medical condition requires the presence of a medical condition as the etiology of depressive symptoms. In Fact, MDD is not diagnosed if depressive symptoms are due to the direct physiologic effects of a medical condition.
Substance/medication-induced depressive disorder	...
Persistent depressive disorder (dysthymia)	...
premenestrual dysphoric disorder	...
Disruptive mood dysregulation disorder	...