Autoimmune lymphoproliferative syndrome other diagnostic studies: Difference between revisions
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== Overview == | ==Overview== | ||
The [[histopathologic]] study may be helpful in the [[diagnosis]] of [[Autoimmune lymphoproliferative syndrome]]([[ALPS]]). Findings suggestive of [[ALPS]] include paracortical expansion due to infiltration of [[polyclonal]] [[TCR]] α/β+ [[DNT]] [[cells]], follicular [[hyperplasia]], and [[polyclonal]] [[plasmacytosis]]. | The [[histopathologic]] study may be helpful in the [[diagnosis]] of [[Autoimmune lymphoproliferative syndrome]]([[ALPS]]). Findings suggestive of [[ALPS]] include paracortical expansion due to infiltration of [[polyclonal]] [[TCR]] α/β+ [[DNT]] [[cells]], follicular [[hyperplasia]], and [[polyclonal]] [[plasmacytosis]]. | ||
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[[Histopathological]] study findings can be helpful to [[diagnose]] [[Autoimmune lymphoproliferative syndrome]]. The findings are | [[Histopathological]] study findings can be helpful to [[diagnose]] [[Autoimmune lymphoproliferative syndrome]]. The findings are | ||
* Paracortical expansion with infiltration of [[polyclonal]] [[TCR]] α/β+ [[DNT]] [[cells]].<ref name="LiHuang2015">{{cite journal|last1=Li|first1=Pu|last2=Huang|first2=Ping|last3=Yang|first3=Ye|last4=Hao|first4=Mu|last5=Peng|first5=Hongwei|last6=Li|first6=Fei|title=Updated Understanding of Autoimmune Lymphoproliferative Syndrome (ALPS)|journal=Clinical Reviews in Allergy & Immunology|volume=50|issue=1|year=2015|pages=55–63|issn=1080-0549|doi=10.1007/s12016-015-8466-y}}</ref> | |||
* [[DNT]] [[cells]] express TIA-1 and CD57, CD45RO negative | *Paracortical expansion with infiltration of [[polyclonal]] [[TCR]] α/β+ [[DNT]] [[cells]].<ref name="LiHuang2015">{{cite journal|last1=Li|first1=Pu|last2=Huang|first2=Ping|last3=Yang|first3=Ye|last4=Hao|first4=Mu|last5=Peng|first5=Hongwei|last6=Li|first6=Fei|title=Updated Understanding of Autoimmune Lymphoproliferative Syndrome (ALPS)|journal=Clinical Reviews in Allergy & Immunology|volume=50|issue=1|year=2015|pages=55–63|issn=1080-0549|doi=10.1007/s12016-015-8466-y}}</ref> | ||
* Follicular [[hyperplasia]] | *[[DNT]] [[cells]] express TIA-1 and CD57, CD45RO negative | ||
* Polyclonal [[plasmacytosis]] | *Follicular [[hyperplasia]] | ||
* [[Spleen]] has expanded [[T cell]] areas dominated by [[DNT]] [[cells]]. | *Polyclonal [[plasmacytosis]] | ||
*[[Spleen]] has expanded [[T cell]] areas dominated by [[DNT]] [[cells]]. | |||
* | |||
==References== | ==References== | ||
Revision as of 02:19, 3 July 2021
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
The histopathologic study may be helpful in the diagnosis of Autoimmune lymphoproliferative syndrome(ALPS). Findings suggestive of ALPS include paracortical expansion due to infiltration of polyclonal TCR α/β+ DNT cells, follicular hyperplasia, and polyclonal plasmacytosis.
Other Diagnostic Studies
Histopathological study findings can be helpful to diagnose Autoimmune lymphoproliferative syndrome. The findings are
- Paracortical expansion with infiltration of polyclonal TCR α/β+ DNT cells.[1]
- DNT cells express TIA-1 and CD57, CD45RO negative
- Follicular hyperplasia
- Polyclonal plasmacytosis
- Spleen has expanded T cell areas dominated by DNT cells.
References
- ↑ Li, Pu; Huang, Ping; Yang, Ye; Hao, Mu; Peng, Hongwei; Li, Fei (2015). "Updated Understanding of Autoimmune Lymphoproliferative Syndrome (ALPS)". Clinical Reviews in Allergy & Immunology. 50 (1): 55–63. doi:10.1007/s12016-015-8466-y. ISSN 1080-0549.