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{{CMG}} {{AE}} {{Kalpana Giri}}





Revision as of 11:51, 20 July 2021

Asplenia Microchapters

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Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Asplenia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

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Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

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Case #1

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Risk calculators and risk factors for Asplenia risk factors

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Kalpana Giri, MBBS[2]


Overview

Common risk factors include: Trauma; atraumatic indication for splenectomy includes: hematological autoimmune disorder, Idiopathic Thrombocytopenic Purpura (ITP), Autoimmune Hemolytic Anemia (AIHA); Surgery includes: unexplained splenomegaly, autoimmune, malignant. Less Common Risk Factors include: mutation in gene RPSA and human genes, connexin 43 and ZIC3.

Risk Factors

Common Risk Factors

Less Common Risk Factors

References

  1. Erdem SB, Genel F, Erdur B, Ozbek E, Gulez N, Mese T (2015). "Asplenia in children with congenital heart disease as a cause of poor outcome". Cent Eur J Immunol. 40 (2): 266–9. doi:10.5114/ceji.2015.52841. PMC 4637402. PMID 26557043.
  2. Browning MG, Bullen N, Nokes T, Tucker K, Coleman M (2017). "The evolving indications for splenectomy". Br J Haematol. 177 (2): 321–324. doi:10.1111/bjh.14060. PMID 27018168.
  3. Bolze A (2014). "[Connecting isolated congenital asplenia to the ribosome]". Biol Aujourdhui. 208 (4): 289–98. doi:10.1051/jbio/2015001. PMID 25840456.
  4. Ahmed SA, Zengeya S, Kini U, Pollard AJ (2010). "Familial isolated congenital asplenia: case report and literature review". Eur J Pediatr. 169 (3): 315–8. doi:10.1007/s00431-009-1030-0. PMID 19618213.

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