COVID-19 Variants of Concern

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief:

Variants of Concern

Alpha B.1.1.7

	Name	First Discovered	Spike Protein Substitutions	BEI Reference Isolate	Importance
Alpha B.1.1.7	20I/501Y.V1	United Kingdom	69del, 70del, 144del, (E484K*), (S494P*), N501Y, A570D, D614G, P681H, T716I, S982A, D1118H (K1191N*)	NR-54000external icon	Approximately 50% increased transmissibility Increased severity according to hospitalizations and case fatality rates Little effect on neutralization by convalescent and post-vaccination sera
Beta B.1.357	20H/501.V2	South Africa	D80A, D215G, 241del, 242del, 243del, K417N, E484K, N501Y, D614G, A701V	NR-55282	Approximately 50% increased transmissibility A marked decrease in the susceptibility to the combination of bamlanivimab and etesevimab monoclonal antibody treatment; however, other EUA monoclonal antibody treatments are available Decreased neutralization by convalescent and post-vaccination sera
Gamma P.1	20J/501Y.V3	Brazil and Japan	L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I	NR-54982	A marked decrease in the susceptibility to the combination of bamlanivimab and etesevimab monoclonal antibody treatment; however, other EUA monoclonal antibody treatments are available Decreased neutralization by convalescent and post-vaccination sera
Delta B.1.617.2
Lambda C.37