Primary ciliary dyskinesia diagnostic study of choice: Difference between revisions
| Line 25: | Line 25: | ||
Candidates presenting with any of the following should be tested to rule out PCD, | Candidates presenting with any of the following should be tested to rule out PCD, | ||
*Situs inversus with respiratory or nasal symptoms | *[[Situs inversus]] with [[respiratory]] or [[nasal]] symptoms | ||
*Neonates born with respiratory distress of unknown origin | *[[Neonates]] born with [[respiratory distress]] of unknown origin | ||
*A Sibling with primary ciliary dyskinesia (PCD ) or a daily life-long wet cough | *A Sibling with primary ciliary dyskinesia (PCD ) or a daily life-long wet cough | ||
*If suspecting cystic fibrosis, also discuss testing for PCD especially if rhinitis, sinusitis, or glue ear symptoms are present. | *If suspecting [[cystic fibrosis]], also discuss testing for PCD especially if [[rhinitis]], [[Sinusitis|sinusitis,]] or glue ear symptoms are present. | ||
*Bronchiectasis of unknown etiology. | *[[Bronchiectasis]] of unknown [[Etiology|etiology.]] | ||
*Serous otitis media in association with upper and lower respiratory disease. | *Serous [[otitis media]] in association with upper and lower respiratory disease. | ||
*Cardiac disease associated with heterotaxy. | *[[Cardiac disease]] associated with heterotaxy. | ||
==References== | ==References== | ||
Revision as of 11:01, 3 September 2021
|
Primary ciliary dyskinesia Microchapters |
|
Differentiating Primary ciliary dyskinesia from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Primary ciliary dyskinesia diagnostic study of choice On the Web |
|
American Roentgen Ray Society Images of Primary ciliary dyskinesia diagnostic study of choice |
|
FDA on Primary ciliary dyskinesia diagnostic study of choice |
|
CDC on Primary ciliary dyskinesia diagnostic study of choice |
|
Primary ciliary dyskinesia diagnostic study of choice in the news |
|
Blogs on Primary ciliary dyskinesia diagnostic study of choice |
|
Risk calculators and risk factors for Primary ciliary dyskinesia diagnostic study of choice |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Hafsa Ghaffar, M.B.B.S[2]
Overview
Diagnostic Study of Choice
Study of choice
There is no single diagnostic test for primary ciliary dyskinesia. A combination of the following techniques could contribute to the diagnosis of Primary ciliary dyskinesia.
- Nasal nitric oxide test (nNo)
- Assessment of ciliary ultrastructure by Transmission Electron Microscopy(TEM), Gold standard.
- Ciliary beat frequency CBF and Ciliary beat pattern CBP.
- Radio-aerosol MCC
- Electron microscopy Tomography.[1]
Sequence of Diagnostic Studies
Electron microscopy should be performed when standard microscopy fails to establish the diagnosis. Repeat testing is often required as most tests are inconclusive.
Name of Diagnostic Criteria
Candidates presenting with any of the following should be tested to rule out PCD,
- Situs inversus with respiratory or nasal symptoms
- Neonates born with respiratory distress of unknown origin
- A Sibling with primary ciliary dyskinesia (PCD ) or a daily life-long wet cough
- If suspecting cystic fibrosis, also discuss testing for PCD especially if rhinitis, sinusitis, or glue ear symptoms are present.
- Bronchiectasis of unknown etiology.
- Serous otitis media in association with upper and lower respiratory disease.
- Cardiac disease associated with heterotaxy.