Primary ciliary dyskinesia screening: Difference between revisions
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==Overview== | ==Overview== | ||
There is insufficient evidence to recommend routine screening for primary ciliary dyskinesia, however patients with persistent sinusitis, rhinitis, and no known etiology should be screened by nasal nitric oxide test, low levels of nasal nitric oxide is diagnostic of primary ciliary dyskinesia and should prompt further testing with biopsy and ciliary beat pattern(CBP). | There is insufficient [[evidence]] to recommend routine [[screening]] for primary ciliary dyskinesia, however patients with persistent [[sinusitis]], [[rhinitis]], and no known [[etiology]] should be screened by [[Nitric oxide|nasal nitric oxide test]], low levels of nasal [[nitric oxide]] is diagnostic of primary ciliary dyskinesia and should prompt further testing with [[biopsy]] and ciliary beat pattern(CBP). | ||
==Screening== | ==Screening== | ||
There is insufficient evidence to recommend routine screening for primary ciliary dyskinesia, however patients with persistent sinusitis, rhinitis, and no known etiology should be screened by nasal nitric oxide test, low levels of nasal nitric oxide is diagnostic of primary ciliary dyskinesia and should prompt further testing with biopsy and ciliary beat pattern(CBP). | There is insufficient evidence to recommend routine [[screening]] for [[primary ciliary dyskinesia]], however patients with persistent [[sinusitis]], [[rhinitis]], and no known [[etiology]] should be screened by nasal [[nitric oxide]] test, low levels of nasal [[nitric oxide]] is [[diagnostic]] of primary ciliary dyskinesia and should prompt further testing with [[biopsy]] and ciliary beat pattern(CBP). | ||
*Nasal nitric oxide test is more reliable in children above 5 years old and in adults because of difficult techniques and interpretation. | *Nasal nitric oxide test is more reliable in children above 5 years old and in adults because of difficult techniques and interpretation. | ||
*Saccharine test is performed to assess transport in the nose and mucociliary clearance.<ref>{{cite web |url=https://www.tandfonline.com/doi/abs/10.1080/01913120590951220 |title=Primary Ciliary Dyskinesia: A Review: Ultrastructural Pathology: Vol 29, No 3-4 |format= |work= |accessdate=}}</ref><ref>{{cite web |url=https://www.medscape.com/answers/299299-121847/which-tests-are-performed-for-primary-ciliary-dyskinesia-kartagener-syndrome-screening |title=Which tests are performed for primary ciliary dyskinesia (Kartagener syndrome) screening? |format= |work= |accessdate=}}</ref> | *Saccharine test is performed to assess transport in the nose and [[mucociliary clearance]].<ref>{{cite web |url=https://www.tandfonline.com/doi/abs/10.1080/01913120590951220 |title=Primary Ciliary Dyskinesia: A Review: Ultrastructural Pathology: Vol 29, No 3-4 |format= |work= |accessdate=}}</ref><ref>{{cite web |url=https://www.medscape.com/answers/299299-121847/which-tests-are-performed-for-primary-ciliary-dyskinesia-kartagener-syndrome-screening |title=Which tests are performed for primary ciliary dyskinesia (Kartagener syndrome) screening? |format= |work= |accessdate=}}</ref> | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Genetic disorders]] | [[Category:Genetic disorders]] | ||
Revision as of 10:58, 5 September 2021
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Primary ciliary dyskinesia Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Hafsa Ghaffar, M.B.B.S[2]
Overview
There is insufficient evidence to recommend routine screening for primary ciliary dyskinesia, however patients with persistent sinusitis, rhinitis, and no known etiology should be screened by nasal nitric oxide test, low levels of nasal nitric oxide is diagnostic of primary ciliary dyskinesia and should prompt further testing with biopsy and ciliary beat pattern(CBP).
Screening
There is insufficient evidence to recommend routine screening for primary ciliary dyskinesia, however patients with persistent sinusitis, rhinitis, and no known etiology should be screened by nasal nitric oxide test, low levels of nasal nitric oxide is diagnostic of primary ciliary dyskinesia and should prompt further testing with biopsy and ciliary beat pattern(CBP).
- Nasal nitric oxide test is more reliable in children above 5 years old and in adults because of difficult techniques and interpretation.
- Saccharine test is performed to assess transport in the nose and mucociliary clearance.[1][2]