Cavernous angioma history and symptoms: Difference between revisions
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*This condition usually presents as significant amount of [[dilation of blood vessels]] lined by a single layer of [[endothelium]]. There is a lack of [[neuronal tissue]] interspersed within the lesion. | *This condition usually presents as significant amount of [[dilation of blood vessels]] lined by a single layer of [[endothelium]]. There is a lack of [[neuronal tissue]] interspersed within the lesion. | ||
*These thinly-walled [[vessels]] are comparable to [[sinusoidal]] cavities with stagnant [[blood]]. | *These thinly-walled [[vessels]] are comparable to [[sinusoidal]] cavities with stagnant [[blood]]. | ||
*The diameters of affected [[blood vessels]] in patients with [[CCM]] vary significantly ranging from millimeters to centimeters. [[CCM]] lesions usually look like raspberries in [[gross appearance]]. | *The diameters of affected [[blood vessels]] in patients with [[CCM]] vary significantly, ranging from millimeters to centimeters. [[CCM]] lesions usually look like raspberries in [[gross appearance]]. | ||
*Patients with CCM can be asymptomatic or can have severe symptoms such as [[headaches]], [[paralysis|paralysis,]] [[seizures]], [[cerebral hemorrhage]], [[Hemorrhagic stroke|hemorrhagic stroke,]] or even death. | *Patients with CCM can be asymptomatic or can have severe symptoms such as [[headaches]], [[paralysis|paralysis,]] [[seizures]], [[cerebral hemorrhage]], [[Hemorrhagic stroke|hemorrhagic stroke,]] or even death. | ||
Revision as of 11:34, 11 March 2022
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Edzel Lorraine Co, D.M.D., M.D.
Overview
Cerebral cavernous malformations (CCMs) have varying presentations and these can be in the form of hemorrhagic stroke, focal neurological deficits, recurrent headaches, and seizures. Howevever, CCMs can be asymptomatic sometimes. [1]
History and Symptoms
- This condition usually presents as significant amount of dilation of blood vessels lined by a single layer of endothelium. There is a lack of neuronal tissue interspersed within the lesion.
- These thinly-walled vessels are comparable to sinusoidal cavities with stagnant blood.
- The diameters of affected blood vessels in patients with CCM vary significantly, ranging from millimeters to centimeters. CCM lesions usually look like raspberries in gross appearance.
- Patients with CCM can be asymptomatic or can have severe symptoms such as headaches, paralysis, seizures, cerebral hemorrhage, hemorrhagic stroke, or even death.
- The nature and severity of the symptoms depend on the lesion's location in the brain. Approximately 70% of these lesions occur in the supratentorial region of the brain.
- The remaining 30% occur in the infratentorial region.
References
- ↑ Zafar A, Quadri SA, Farooqui M, Ikram A, Robinson M, Hart BL; et al. (2019). "Familial Cerebral Cavernous Malformations". Stroke. 50 (5): 1294–1301. doi:10.1161/STROKEAHA.118.022314. PMC 6924279 Check
|pmc=value (help). PMID 30909834.