Gangrene pathophysiology: Difference between revisions
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{{CMG}}{{AE}} [[User:Edzelco|Edzel Lorraine Co, D.M.D., M.D.]] | {{CMG}}{{AE}} [[User:Edzelco|Edzel Lorraine Co, D.M.D., M.D.]] | ||
==Overview== | |||
The three main types of [[gangrene]] occur in different mechanisms. [[Dry gangrene]] involves a reduction in the [[perfusion]] of the [[arteries]] results in the compensatory dilation of the [[arterioles]], which eventually results in [[distal]] [[edema]], and damage of the [[endothelial tissue]].<ref name="pmid32809387">{{cite journal| author=| title=StatPearls | journal= | year= 2022 | volume= | issue= | pages= | pmid=32809387 | doi= | pmc= | url= }} </ref> In [[wet gangrene]], [[saprogenic]] [[microorganisms]] (''[[Bacillus fusiformis]]'', or ''[[Clostridium perfringens]]'') infect the [[tissues]], thereby causing an emission of a foul odor and [[edema]]. <ref name="pmid29910628">{{cite journal| author=Al Wahbi A| title=Autoamputation of diabetic toe with dry gangrene: a myth or a fact? | journal=Diabetes Metab Syndr Obes | year= 2018 | volume= 11 | issue= | pages= 255-264 | pmid=29910628 | doi=10.2147/DMSO.S164199 | pmc=5987754 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29910628 }} </ref> Multiplication of [[exotoxins]] from ''[[Clostridium perfringens]]'' and [[group A steptococcus]] is responsible for the local [[tissue]] destruction and [[systemic infection]] in [[gas gangrene]].<ref name="pmid1884064">{{cite journal| author=Lehner PJ, Powell H| title=Gas gangrene. | journal=BMJ | year= 1991 | volume= 303 | issue= 6796 | pages= 240-2 | pmid=1884064 | doi=10.1136/bmj.303.6796.240 | pmc=1670510 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1884064 }} </ref> | |||
==Pathophysiology== | ==Pathophysiology== | ||
===Dry Gangrene=== | ===Dry Gangrene=== | ||
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===Gas Gangrene=== | ===Gas Gangrene=== | ||
==References== | ==References== | ||
Revision as of 05:49, 6 April 2022
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Gangrene Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Edzel Lorraine Co, D.M.D., M.D.
Overview
The three main types of gangrene occur in different mechanisms. Dry gangrene involves a reduction in the perfusion of the arteries results in the compensatory dilation of the arterioles, which eventually results in distal edema, and damage of the endothelial tissue.[1] In wet gangrene, saprogenic microorganisms (Bacillus fusiformis, or Clostridium perfringens) infect the tissues, thereby causing an emission of a foul odor and edema. [2] Multiplication of exotoxins from Clostridium perfringens and group A steptococcus is responsible for the local tissue destruction and systemic infection in gas gangrene.[3]
Pathophysiology
Dry Gangrene
Wet Gangrene
Gas Gangrene
References
- ↑ "StatPearls". 2022. PMID 32809387 Check
|pmid=value (help). - ↑ Al Wahbi A (2018). "Autoamputation of diabetic toe with dry gangrene: a myth or a fact?". Diabetes Metab Syndr Obes. 11: 255–264. doi:10.2147/DMSO.S164199. PMC 5987754. PMID 29910628.
- ↑ Lehner PJ, Powell H (1991). "Gas gangrene". BMJ. 303 (6796): 240–2. doi:10.1136/bmj.303.6796.240. PMC 1670510. PMID 1884064.