Monkeypox pathophysiology: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 11: | Line 11: | ||
* Direct contact with contaminated materials such as clothing or linens | * Direct contact with contaminated materials such as clothing or linens | ||
* Respiratory secretions when people have close, face-to-face contact | * Respiratory secretions when people have close, face-to-face contact | ||
==Genetics== | |||
* Monkeypox virus is a member of orthopoxvirus genus, which is a subdivision of Chordopoxvirinae that belongs to family Poxviridae. | |||
* It is a linear double-stranded DNA virus that multiplies in the cytoplasm of infected cell. | |||
* All the proteins required for viral DNA replication, transcription, virion assembly, and egress are encoded by the MPXV genome. | |||
* The genes encoding for housekeeping functions are present in the central region of the genome, and the genes encoding the virus–host interactions are located in the termini region. | |||
* The nucleotide sequence within the central region of the monkeypox virus genome is 96.3% identical with that of smallpox virus. Nonetheless, monkeypox virus is not the direct ancestor of smallpox virus and is unlikely to naturally acquire all properties of smallpox virus. | |||
==References== | ==References== | ||
Revision as of 19:51, 13 June 2022
|
Monkeypox Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Monkeypox pathophysiology On the Web |
|
American Roentgen Ray Society Images of Monkeypox pathophysiology |
|
Risk calculators and risk factors for Monkeypox pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief:
Overview
Pathophysiology
Transmission
Monkeypox can be transmitted by[1]
- Direct contact with body fluids or sores on the body of someone who has monkeypox
- Direct contact with contaminated materials such as clothing or linens
- Respiratory secretions when people have close, face-to-face contact
Genetics
- Monkeypox virus is a member of orthopoxvirus genus, which is a subdivision of Chordopoxvirinae that belongs to family Poxviridae.
- It is a linear double-stranded DNA virus that multiplies in the cytoplasm of infected cell.
- All the proteins required for viral DNA replication, transcription, virion assembly, and egress are encoded by the MPXV genome.
- The genes encoding for housekeeping functions are present in the central region of the genome, and the genes encoding the virus–host interactions are located in the termini region.
- The nucleotide sequence within the central region of the monkeypox virus genome is 96.3% identical with that of smallpox virus. Nonetheless, monkeypox virus is not the direct ancestor of smallpox virus and is unlikely to naturally acquire all properties of smallpox virus.