Monkeypox pathophysiology: Difference between revisions
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==Genetics== | ==Genetics== | ||
* Monkeypox virus is a member of orthopoxvirus genus, which is a subdivision of Chordopoxvirinae that belongs to family Poxviridae. | * Monkeypox virus is a member of orthopoxvirus genus, which is a subdivision of Chordopoxvirinae that belongs to family Poxviridae<ref name="urlICTV">{{cite web |url=https://talk.ictvonline.org/taxonomy/ |title=ICTV |format= |work= |accessdate=}}</ref>. | ||
* It is a linear double-stranded DNA virus that multiplies in the cytoplasm of infected cell. | * It is a linear double-stranded DNA virus that multiplies in the cytoplasm of infected cell<ref name="pmid9562888">{{cite journal| author=Holland J, Domingo E| title=Origin and evolution of viruses. | journal=Virus Genes | year= 1998 | volume= 16 | issue= 1 | pages= 13-21 | pmid=9562888 | doi=10.1023/a:1007989407305 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9562888 }} </ref>. | ||
* All the proteins required for viral DNA replication, transcription, virion assembly, and egress are encoded by the MPXV genome. | * All the proteins required for viral DNA replication, transcription, virion assembly, and egress are encoded by the MPXV genome. | ||
* The genes encoding for housekeeping functions are present in the central region of the genome, and the genes encoding the virus–host interactions are located in the termini region. | * The genes encoding for housekeeping functions are present in the central region of the genome, and the genes encoding the virus–host interactions are located in the termini region<ref name="pmid33167496">{{cite journal| author=Alakunle E, Moens U, Nchinda G, Okeke MI| title=Monkeypox Virus in Nigeria: Infection Biology, Epidemiology, and Evolution. | journal=Viruses | year= 2020 | volume= 12 | issue= 11 | pages= | pmid=33167496 | doi=10.3390/v12111257 | pmc=7694534 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=33167496 }} </ref>. | ||
* The nucleotide sequence within the central region of the monkeypox virus genome is 96.3% identical with that of smallpox virus. Nonetheless, monkeypox virus is not the direct ancestor of smallpox virus and is unlikely to naturally acquire all properties of smallpox virus. | * The nucleotide sequence within the central region of the monkeypox virus genome is 96.3% identical with that of smallpox virus. Nonetheless, monkeypox virus is not the direct ancestor of smallpox virus and is unlikely to naturally acquire all properties of smallpox virus<ref name="pmid11734207">{{cite journal| author=Shchelkunov SN, Totmenin AV, Babkin IV, Safronov PF, Ryazankina OI, Petrov NA | display-authors=etal| title=Human monkeypox and smallpox viruses: genomic comparison. | journal=FEBS Lett | year= 2001 | volume= 509 | issue= 1 | pages= 66-70 | pmid=11734207 | doi=10.1016/s0014-5793(01)03144-1 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11734207 }} </ref>. | ||
==References== | ==References== | ||
Revision as of 19:55, 13 June 2022
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Monkeypox pathophysiology On the Web |
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Risk calculators and risk factors for Monkeypox pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief:
Overview
Pathophysiology
Transmission
Monkeypox can be transmitted by[1]
- Direct contact with body fluids or sores on the body of someone who has monkeypox
- Direct contact with contaminated materials such as clothing or linens
- Respiratory secretions when people have close, face-to-face contact
Genetics
- Monkeypox virus is a member of orthopoxvirus genus, which is a subdivision of Chordopoxvirinae that belongs to family Poxviridae[2].
- It is a linear double-stranded DNA virus that multiplies in the cytoplasm of infected cell[3].
- All the proteins required for viral DNA replication, transcription, virion assembly, and egress are encoded by the MPXV genome.
- The genes encoding for housekeeping functions are present in the central region of the genome, and the genes encoding the virus–host interactions are located in the termini region[4].
- The nucleotide sequence within the central region of the monkeypox virus genome is 96.3% identical with that of smallpox virus. Nonetheless, monkeypox virus is not the direct ancestor of smallpox virus and is unlikely to naturally acquire all properties of smallpox virus[5].
References
- ↑ "CDC Monkeypox Response: Transmission | CDC Online Newsroom | CDC".
- ↑ "ICTV".
- ↑ Holland J, Domingo E (1998). "Origin and evolution of viruses". Virus Genes. 16 (1): 13–21. doi:10.1023/a:1007989407305. PMID 9562888.
- ↑ Alakunle E, Moens U, Nchinda G, Okeke MI (2020). "Monkeypox Virus in Nigeria: Infection Biology, Epidemiology, and Evolution". Viruses. 12 (11). doi:10.3390/v12111257. PMC 7694534 Check
|pmc=value (help). PMID 33167496 Check|pmid=value (help). - ↑ Shchelkunov SN, Totmenin AV, Babkin IV, Safronov PF, Ryazankina OI, Petrov NA; et al. (2001). "Human monkeypox and smallpox viruses: genomic comparison". FEBS Lett. 509 (1): 66–70. doi:10.1016/s0014-5793(01)03144-1. PMID 11734207.