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| {{SI}}
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| {{CMG}}
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| {{EH}}
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| == Overview ==
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| '''Corticotropin-releasing hormone''' ('''CRH'''), originally named '''corticotropin-releasing factor''' ('''CRF'''), and also called '''corticoliberin''', is a [[polypeptide]] [[hormone]] and [[neurotransmitter]] involved in the [[stress (medicine)|stress response]].
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| ==Hormonal actions==
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| CRH is produced by neuroendocrine cells in the [[paraventricular nucleus]] of the [[hypothalamus]] and is released from neurosecretory terminals of these neurons into the primary capillary plexus of the [[hypothalamo-hypophyseal portal system]]. The portal system carries the CRH to the [[anterior pituitary|anterior lobe]] of the [[pituitary gland|pituitary]], where it stimulates [[corticotrope]]s to secrete [[corticotropin]] (ACTH) and other biologically active substances (for example [[β-endorphin]]).
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| ά-helical CRH-(9--41) acts as a CRH antagonist<ref>Santos, Javier, Paul R. Saunders, Nico P. M. Hanssen,
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| Ping-Chang Yang, Derrick Yates, Jack A. Groot, and Mary H. Perdue. Corticotropin-releasing hormone mimics
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| stress-induced colonic epithelial pathophysiology in the rat. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G391-G399, 1999</ref>.
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| ==Role in parturition==
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| CRH is also synthesized by the [[placenta]] and seems to determine the duration of [[pregnancy]]<ref>http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/H/Hypothalamus.html#CRH</ref>.
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| ==Structure==
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| The 41-[[amino acid]] sequence of CRH was first discovered in sheep by Vale ''et al'' in [[1981]]<ref>Vale,W., Spiess,J., Rivier,C. and Rivier,J. ''Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin'' Science 213 (4514), 1394-1397 (1981)</ref>. Its full sequence is
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| SQEPPISLDLTFHLLREVLEMTKADQLAQQAHSNRKLLDIA
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| ==See also==
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| * [[Corticotropin releasing hormone receptor]]
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| * [[Proopiomelanocortin]]
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| * [[Hypothalamic-pituitary-adrenal axis]]
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| ==References==
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| <references/>
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| == Acknowledgements ==
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| The content on this page was first contributed by: C. Michael Gibson, M.S., M.D.
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| Initial content for this page in some instances came from [http://www.wikipedia.org Wikipedia]
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| '''List of contributors:'''
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| == Suggested Reading and Key General References ==
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| == Suggested Links and Web Resources ==
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| == For Patients ==
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| {{SIB}}
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| ----
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| [[cs:Kortikoliberin]]
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| [[de:Corticotropin Releasing Hormone]]
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| [[fr:Corticolibérine]]
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| [[it:Ormone di liberazione della corticotropina]]
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| [[mk:Адренокортикотропен ослободувачки хормон]]
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| [[ja:副腎皮質刺激ホルモン放出ホルモン]]
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| [[pl:Kortykoliberyna]]
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| [[ru:Кортиколиберин]]
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| [[sl:Kortikoliberin]]
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| [[Category:DiseaseState]]
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| [[Category:Hormone]]
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| [[Category:Endocrinology]]
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