Myoglobinuria: Difference between revisions
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==Overview== | ==Overview== | ||
'''Myoglobinuria''' is the presence of [[myoglobin]] in the urine, usually associated with [[rhabdomyolysis]] or muscle destruction. Myoglobin is present in [[muscle]] cells as a reserve of [[oxygen]]. | '''Myoglobinuria''' is the presence of [[myoglobin]] in the urine, usually associated with [[rhabdomyolysis]] or muscle destruction. Myoglobin is present in [[muscle]] cells as a reserve of [[oxygen]]. | ||
==Pathophysiology== | |||
Under ideal situations myoglobin will be filtered and excreted with the urine, but if too much myoglobin is released into the circulation or in case of renal problems, it can occlude the renal filtration system leading to acute tubular necrosis and acute [[renal insufficiency]]. | |||
==Differential diagnosis of causes of myoglobinuria== | ==Differential diagnosis of causes of myoglobinuria== | ||
[[Physical trauma|Trauma]], vascular problems, [[venom]]s, certain drugs and other situations can destroy or damage the muscle, releasing myoglobin to the circulation and thus to the kidneys. | [[Physical trauma|Trauma]], vascular problems, [[venom]]s, certain drugs and other situations can destroy or damage the muscle, releasing myoglobin to the circulation and thus to the kidneys. | ||
Miscellaneous syndromes | |||
* [[Rhabdomyolysis]] | |||
* [[Meyer-Betz]] disease | |||
Autosomal recessive conditions | |||
* [[Glycogenosis type 5]] | |||
* [[Phosphogylcerate mutase 2 deficiency]] | |||
Cardiac and vascular conditions | |||
* [[Myocarditis]] | |||
Inflammatory conditions | |||
* [[Myositis]] | |||
Trauma, mechanical and physical conditions | |||
* [[Burns]] | |||
* [[Crush syndrome]] | |||
==Differentiating myoglobinuria from [[hemoglobinuria]]== | ==Differentiating myoglobinuria from [[hemoglobinuria]]== | ||
Revision as of 18:26, 19 January 2009
| Myoglobinuria | |
 | |
|---|---|
| Model of helical domains in myoglobin. | |
| ICD-10 | R82.1 |
| ICD-9 | 791.3 |
| DiseasesDB | 23059 |
| eMedicine | ped/1535 |
| MeSH | D009212 |
Template:Search infobox Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Myoglobinuria is the presence of myoglobin in the urine, usually associated with rhabdomyolysis or muscle destruction. Myoglobin is present in muscle cells as a reserve of oxygen.
Pathophysiology
Under ideal situations myoglobin will be filtered and excreted with the urine, but if too much myoglobin is released into the circulation or in case of renal problems, it can occlude the renal filtration system leading to acute tubular necrosis and acute renal insufficiency.
Differential diagnosis of causes of myoglobinuria
Trauma, vascular problems, venoms, certain drugs and other situations can destroy or damage the muscle, releasing myoglobin to the circulation and thus to the kidneys.
Miscellaneous syndromes
- Rhabdomyolysis
- Meyer-Betz disease
Autosomal recessive conditions
Cardiac and vascular conditions
Inflammatory conditions
Trauma, mechanical and physical conditions
Differentiating myoglobinuria from hemoglobinuria
After centrifuge, the serum of myologinuria is clear, where the serum of hemoglobinuria after centrifuge is pink.
External links
- Overview at wustl.edu
Template:Abnormal clinical and laboratory findings Template:SIB de:Myoglobinurie