Drug-induced autoimmune hemolytic anemia: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
m Bot: Automated text replacement (-{{SIB}} + & -{{EH}} + & -{{EJ}} + & -{{Editor Help}} + & -{{Editor Join}} +) |
||
| Line 16: | Line 16: | ||
{{CMG}} | {{CMG}} | ||
==Overview== | ==Overview== | ||
| Line 22: | Line 22: | ||
==Differential diagnosis of underlying causes== | ==Differential diagnosis of underlying causes== | ||
[[Penicillin]] in high doses can induce immune mediated hemolysis<ref name="pmid10815791">{{cite journal |author=Stroncek D, Procter JL, Johnson J |title=Drug-induced hemolysis: cefotetan-dependent hemolytic anemia mimicking an acute intravascular immune transfusion reaction |journal=Am. J. Hematol. |volume=64 |issue=1 |pages=67–70 |year=2000 |month=May |pmid=10815791 |doi= |url=http://dx.doi.org/10.1002/(SICI)1096-8652(200005)64:1<67::AID-AJH12>3.0.CO;2-Z}}</ref> via the [[hapten]] mechanism in which antibodies are targeted against the combination of penicillin in association with red blood | [[Penicillin]] in high doses can induce immune mediated [[hemolysis]]<ref name="pmid10815791">{{cite journal |author=Stroncek D, Procter JL, Johnson J |title=Drug-induced hemolysis: cefotetan-dependent hemolytic anemia mimicking an acute intravascular immune transfusion reaction |journal=Am. J. Hematol. |volume=64 |issue=1 |pages=67–70 |year=2000 |month=May |pmid=10815791 |doi= |url=http://dx.doi.org/10.1002/(SICI)1096-8652(200005)64:1<67::AID-AJH12>3.0.CO;2-Z}}</ref> via the [[hapten]] mechanism in which antibodies are targeted against the combination of [[penicillin]] in association with [[red blood cell]]s. Complement is activated by the attached antibody leading to the removal of [[red blood cell]]s by the spleen. | ||
The drug itself can be targeted by the immune system, e.g. by [[IgE]] in a [[Type I hypersensitivity reaction]] to penicillin, rarely leading to anaphylaxis. | The drug itself can be targeted by the [[immune system]], e.g. by [[IgE]] in a [[Type I hypersensitivity reaction]] to [[penicillin]], rarely leading to [[anaphylaxis]]. | ||
==References== | ==References== | ||
| Line 30: | Line 30: | ||
{{Hematology}} | {{Hematology}} | ||
[[Category:Blood disorders]] | [[Category:Blood disorders]] | ||
[[Category:Hematology]] | [[Category:Hematology]] | ||
Revision as of 00:55, 9 August 2012
| Drug-induced autoimmune hemolytic anemia | |
| ICD-10 | D59.0 |
|---|---|
| ICD-9 | 283 |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Drug-induced autoimmune hemolytic anaemia is a form of hemolytic anaemia.
Differential diagnosis of underlying causes
Penicillin in high doses can induce immune mediated hemolysis[1] via the hapten mechanism in which antibodies are targeted against the combination of penicillin in association with red blood cells. Complement is activated by the attached antibody leading to the removal of red blood cells by the spleen.
The drug itself can be targeted by the immune system, e.g. by IgE in a Type I hypersensitivity reaction to penicillin, rarely leading to anaphylaxis.
References
- ↑ Stroncek D, Procter JL, Johnson J (2000). <67::AID-AJH12>3.0.CO;2-Z "Drug-induced hemolysis: cefotetan-dependent hemolytic anemia mimicking an acute intravascular immune transfusion reaction". Am. J. Hematol. 64 (1): 67–70. PMID 10815791. Unknown parameter
|month=ignored (help)