PEComa: Difference between revisions
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Revision as of 21:40, 20 January 2012
PEComa | |
Histopathologic image of renal angiomyolipoma. Nephrectomy specimen. H&E stain. | |
MeSH | D054973 |
WikiDoc Resources for PEComa |
Articles |
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Media |
Evidence Based Medicine |
Clinical Trials |
Ongoing Trials on PEComa at Clinical Trials.gov Clinical Trials on PEComa at Google
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Guidelines / Policies / Govt |
US National Guidelines Clearinghouse on PEComa
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Books |
News |
Commentary |
Definitions |
Patient Resources / Community |
Directions to Hospitals Treating PEComa Risk calculators and risk factors for PEComa
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Healthcare Provider Resources |
Continuing Medical Education (CME) |
International |
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Business |
Experimental / Informatics |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
In oncology, PEComa, also PEC tumour and perivascular epithelioid cell tumour, is a type of mesenchymal tumour consisting of perivascular epithelioid cells (PECs).[1]
Histologic appearance
PECs consist of perivascular epithelioid cells with a clear/granular cytoplasm and central round nucleus without prominent nucleoli.
Immunohistochemical markers
PECs typically stain for melanocytic markers (HMB-45, Melan A (Mart 1), Mitf) and myogenic markers (actin).
PECs and other conditions
PECs bear significant histologic and immunohistochemical similarity to:
- angiomyolipoma,
- clear-cell sugar tumour (CCST),
- lymphangioleiomyomatosis, and,
- clear-cell myomelanocytic tumour of ligamentum teres/falciform ligament.
Thus, it has been advocated that the above could be classified PEComas.[1]
Etiology
The precursor cell of PEComas is currently unknown.[1] Genetically, PECs are linked to the tuberous sclerosis genes TSC1 and TSC2.
References