Kernicterus: Difference between revisions
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==Overview== | |||
'''Kernicterus''' is damage to the brain centers of infants caused by increased levels of unconjugated-indirect [[bilirubin]] which is free (not bound to albumin). This may be due to several underlying pathologic processes. Newborn babies are often [[polycythemic]], meaning they have too many [[red blood cell]]s. When they break down the cells, one of the byproducts is [[bilirubin]], which circulates in the blood and causes [[Neonatal_jaundice|jaundice]]. Alternately, Rh incompatibility between mother and fetus may cause [[hemolysis]] of fetal red blood cells, thereby releasing unconjugated bilirubin into the fetal blood. Since the fetal [[blood brain barrier]] is not fully formed, some of this released bilirubin enters the brain and interferes with normal neuronal development. | '''Kernicterus''' is damage to the brain centers of infants caused by increased levels of unconjugated-indirect [[bilirubin]] which is free (not bound to albumin). This may be due to several underlying pathologic processes. Newborn babies are often [[polycythemic]], meaning they have too many [[red blood cell]]s. When they break down the cells, one of the byproducts is [[bilirubin]], which circulates in the blood and causes [[Neonatal_jaundice|jaundice]]. Alternately, Rh incompatibility between mother and fetus may cause [[hemolysis]] of fetal red blood cells, thereby releasing unconjugated bilirubin into the fetal blood. Since the fetal [[blood brain barrier]] is not fully formed, some of this released bilirubin enters the brain and interferes with normal neuronal development. | ||
Kernicterus may also be found in infants as a symptom of [[Crigler-Najjar syndrome]] type I, a hereditary hyperbilirubinemia that is fatal within 18 months of life. | Kernicterus may also be found in infants as a symptom of [[Crigler-Najjar syndrome]] type I, a hereditary hyperbilirubinemia that is fatal within 18 months of life. | ||
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Some medications, such as the antibiotic [[co-trimoxazole]] (a combination of [[trimethoprim]]/[[sulfamethoxazole]]) may induce this disorder in the baby, either when taken by the mother or given directly to the baby, due to displacement of [[bilirubin]] from binding sites on [[serum albumin]]. The [[bilirubin]] is then free to pass into the [[Central Nervous System]], because the baby's [[blood-brain barrier]] is not fully developed. | Some medications, such as the antibiotic [[co-trimoxazole]] (a combination of [[trimethoprim]]/[[sulfamethoxazole]]) may induce this disorder in the baby, either when taken by the mother or given directly to the baby, due to displacement of [[bilirubin]] from binding sites on [[serum albumin]]. The [[bilirubin]] is then free to pass into the [[Central Nervous System]], because the baby's [[blood-brain barrier]] is not fully developed. | ||
The word origantes from the | The word origantes from the German ''kern'', nucleus, kernel, and the [[Greek language|Greek]] ''ikterus'', jaundice.<ref>{{cite web | ||
|url = http://dissertations.ub.rug.nl/FILES/faculties/medicine/2006/a.m.hafkamp/01_1.pdf | |url = http://dissertations.ub.rug.nl/FILES/faculties/medicine/2006/a.m.hafkamp/01_1.pdf | ||
|title = Oral treatment of unconjugated hyperbilirubinemia | |title = Oral treatment of unconjugated hyperbilirubinemia | ||
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|format = PDF | |format = PDF | ||
|work = PhD thesis | |work = PhD thesis | ||
|publisher = Department of Pediatrics; Center for Liver, Digestive and Metabolic Diseases; University Medical Center | |publisher = Department of Pediatrics; Center for Liver, Digestive and Metabolic Diseases; University Medical Center Groningen | ||
|pages = p. 21}}</ref> | |pages = p. 21}}</ref> | ||
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[[Category:German loanwords]] | [[Category:German loanwords]] | ||
[[es:Kernicterus]] | [[es:Kernicterus]] | ||
[[pl:Żółtaczka jąder podkorowych mózgu]] | [[pl:Żółtaczka jąder podkorowych mózgu]] | ||
[[ru:Ядерная желтуха]] | [[ru:Ядерная желтуха]] | ||
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[[Category:Neurology]] | [[Category:Neurology]] | ||
{{SIB}} | {{SIB}} | ||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
Revision as of 14:50, 4 June 2009
| Kernicterus | |
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|---|---|
| Bilirubin | |
| ICD-10 | P57 |
| ICD-9 | 773.4, 774.7 |
| DiseasesDB | 7161 |
| MedlinePlus | 003243 |
| eMedicine | ped/1247 |
| MeSH | D007647 |
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Overview
Kernicterus is damage to the brain centers of infants caused by increased levels of unconjugated-indirect bilirubin which is free (not bound to albumin). This may be due to several underlying pathologic processes. Newborn babies are often polycythemic, meaning they have too many red blood cells. When they break down the cells, one of the byproducts is bilirubin, which circulates in the blood and causes jaundice. Alternately, Rh incompatibility between mother and fetus may cause hemolysis of fetal red blood cells, thereby releasing unconjugated bilirubin into the fetal blood. Since the fetal blood brain barrier is not fully formed, some of this released bilirubin enters the brain and interferes with normal neuronal development. Kernicterus may also be found in infants as a symptom of Crigler-Najjar syndrome type I, a hereditary hyperbilirubinemia that is fatal within 18 months of life.
In adults and older children, jaundice is harmless in and of itself. However, the tissues protecting the brain (the blood-brain barrier) are immature in newborns. Bilirubin penetrates the brain and is deposited in the basal ganglia, causing irreversible damage. Depending on the level of exposure, the effects range from unnoticeable to severe brain damage.
Some medications, such as the antibiotic co-trimoxazole (a combination of trimethoprim/sulfamethoxazole) may induce this disorder in the baby, either when taken by the mother or given directly to the baby, due to displacement of bilirubin from binding sites on serum albumin. The bilirubin is then free to pass into the Central Nervous System, because the baby's blood-brain barrier is not fully developed.
The word origantes from the German kern, nucleus, kernel, and the Greek ikterus, jaundice.[1]
References
- ↑ Anja M. Hafkamp (2006). "Oral treatment of unconjugated hyperbilirubinemia" (PDF). PhD thesis. Department of Pediatrics; Center for Liver, Digestive and Metabolic Diseases; University Medical Center Groningen. pp. p. 21. Retrieved 2008-09-06.
External links
- BiliTool - Hyperbilirubinemia Risk Assessment for Newborns
- CDC’s National Center on Birth Defects and Developmental Disabilities
- PICK - Parents of Infants and Children with Kernicterus
Template:Certain conditions originating in the perinatal period
External links
- CDC’s National Center on Birth Defects and Developmental Disabilities
- PICK - Parents of Infants and Children with Kernicterus
Template:Certain conditions originating in the perinatal period Template:SIB