Detoxication: Difference between revisions
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The major metabolites formed from most [[drug metabolism]] are '''detoxication products'''. | The major metabolites formed from most [[drug metabolism]] are '''detoxication products'''. | ||
There are two common patterns observed: | There are two common patterns observed: | ||
#A drug with potent pharmacological activity is converted to a major metabolite with markedly reduced or no pharmacological activity (''e.g.'', [[Pentobarbital]] and | #A drug with potent pharmacological activity is converted to a major metabolite with markedly reduced or no pharmacological activity (''e.g.'', [[Pentobarbital]] and Hydroxypentobarbital) | ||
#A drug is converted to a metabolite with roughly equivalent or slightly lower pharmacological activity. | #A drug is converted to a metabolite with roughly equivalent or slightly lower pharmacological activity. | ||
Revision as of 16:21, 16 April 2009
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The major metabolites formed from most drug metabolism are detoxication products. There are two common patterns observed:
- A drug with potent pharmacological activity is converted to a major metabolite with markedly reduced or no pharmacological activity (e.g., Pentobarbital and Hydroxypentobarbital)
- A drug is converted to a metabolite with roughly equivalent or slightly lower pharmacological activity.