Lactoferrin: Difference between revisions
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'''Lactoferrin''' (LF), a [[globular protein|globular]] multifunctional protein with antimicrobial activity ([[bacteriocide]], [[fungicide]]), is part of the innate defense, mainly at mucoses. Lactoferrin is found in [[milk]] and many mucosal secretions such as [[tears]] and saliva. Lactoferrin is also present in secondary granules of [[neutrophil|PMN]] and also is secreted by some [[acinar cells]]. Human [[colostrum]] has the highest concentration, followed by human milk, then cow milk. | '''Lactoferrin''' (LF), a [[globular protein|globular]] multifunctional protein with antimicrobial activity ([[bacteriocide]], [[fungicide]]), is part of the innate defense, mainly at mucoses. Lactoferrin is found in [[milk]] and many mucosal secretions such as [[tears]] and saliva. Lactoferrin is also present in secondary granules of [[neutrophil|PMN]] and also is secreted by some [[acinar cells]]. Human [[colostrum]] has the highest concentration, followed by human milk, then cow milk. | ||
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{{Glycoproteins}} | {{Glycoproteins}} | ||
[[Category:Proteins]] | [[Category:Proteins]] | ||
[[es:lactoferrina]] | [[es:lactoferrina]] | ||
[[he:לקטופרין]] | [[he:לקטופרין]] | ||
Revision as of 16:45, 9 August 2012
| Lactoferrin | |
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| Identifiers | |
| Symbol | LF |
| Entrez | 4057 |
| HUGO | 6720 |
| OMIM | 150210 |
| RefSeq | NM_002343 |
| UniProt | P02788 |
| Other data | |
| Locus | Chr. 3 q21-23 |
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WikiDoc Resources for Lactoferrin |
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Most recent articles on Lactoferrin Most cited articles on Lactoferrin |
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Powerpoint slides on Lactoferrin |
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Evidence Based Medicine |
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Ongoing Trials on Lactoferrin at Clinical Trials.gov Clinical Trials on Lactoferrin at Google
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US National Guidelines Clearinghouse on Lactoferrin
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Definitions |
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Patient resources on Lactoferrin Discussion groups on Lactoferrin Patient Handouts on Lactoferrin Directions to Hospitals Treating Lactoferrin Risk calculators and risk factors for Lactoferrin
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Causes & Risk Factors for Lactoferrin |
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Experimental / Informatics |
Lactoferrin (LF), a globular multifunctional protein with antimicrobial activity (bacteriocide, fungicide), is part of the innate defense, mainly at mucoses. Lactoferrin is found in milk and many mucosal secretions such as tears and saliva. Lactoferrin is also present in secondary granules of PMN and also is secreted by some acinar cells. Human colostrum has the highest concentration, followed by human milk, then cow milk.
Structure
Lactoferrin belongs to the transferrin family proteins (TF, melanotransferrin, ovotransferin, etc.). Its molecular mass is 80,000 u (80 kDa).
Function
Lactoferrin antimicrobial activity is due partly to its high affinity for Fe (ferric state). LF proteolysis produces lactoferricin, kaliocin-1 small peptides with antimicrobial activity.
Lactoferrin receptors have been found on brush-border cells, PMN, monocytes, Mφ and activated lymphocytes.
Genetics
Genetically modified (transgenic) rice LL601 (Liberty Link 601) produces this protein.
External links
- Thompson.net Supported information about lactoferrin.
- FDA Lactoferrin Considered Safe to Fight E. Coli.
- lactoferrinresearch.org
- Agennix.com A biopharmaceutical company focused on developing protein-based drugs for cancer and diabetic ulcers.
- Pharming.com A biopharmaceutical company producing lactoferrin.