MMDA (psychedelic)

MMDA
Chemical name	3-methoxy-4,5-Methylenedioxyamphetamine or 1-(7-methoxy-1,3-benzodioxol-5-yl)propan-2-amine
Chemical formula	C11H15NO3
Molecular mass	209.2417 g/mol
Melting point	133-134 °C (hydrochloride)
CAS numbers	13674-05-0
SMILES	CC(N)Cc1cc2OCOc2c(c1)OC

WikiDoc Resources for MMDA (psychedelic)
Articles
Most recent articles on MMDA (psychedelic) Most cited articles on MMDA (psychedelic) Review articles on MMDA (psychedelic) Articles on MMDA (psychedelic) in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on MMDA (psychedelic) Images of MMDA (psychedelic) Photos of MMDA (psychedelic) Podcasts & MP3s on MMDA (psychedelic) Videos on MMDA (psychedelic)
Evidence Based Medicine
Cochrane Collaboration on MMDA (psychedelic) Bandolier on MMDA (psychedelic) TRIP on MMDA (psychedelic)
Clinical Trials
Ongoing Trials on MMDA (psychedelic) at Clinical Trials.gov Trial results on MMDA (psychedelic) Clinical Trials on MMDA (psychedelic) at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on MMDA (psychedelic) NICE Guidance on MMDA (psychedelic) NHS PRODIGY Guidance FDA on MMDA (psychedelic) CDC on MMDA (psychedelic)
Books
Books on MMDA (psychedelic)
News
MMDA (psychedelic) in the news Be alerted to news on MMDA (psychedelic) News trends on MMDA (psychedelic)
Commentary
Blogs on MMDA (psychedelic)
Definitions
Definitions of MMDA (psychedelic)
Patient Resources / Community
Patient resources on MMDA (psychedelic) Discussion groups on MMDA (psychedelic) Patient Handouts on MMDA (psychedelic) Directions to Hospitals Treating MMDA (psychedelic) Risk calculators and risk factors for MMDA (psychedelic)
Healthcare Provider Resources
Symptoms of MMDA (psychedelic) Causes & Risk Factors for MMDA (psychedelic) Diagnostic studies for MMDA (psychedelic) Treatment of MMDA (psychedelic)
Continuing Medical Education (CME)
CME Programs on MMDA (psychedelic)
International
MMDA (psychedelic) en Espanol MMDA (psychedelic) en Francais
Business
MMDA (psychedelic) in the Marketplace Patents on MMDA (psychedelic)
Experimental / Informatics
List of terms related to MMDA (psychedelic)

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Overview

MMDA, or 3-methoxy-4,5-methylenedioxyamphetamine, is a stimulant, a psychedelic drug, an entheogen, and an entactogen. It is a substituted Amphetamine and an analogue of MDA, Lophophine and MDMA (Ecstasy). It bears resemblance to the psychopharmacologically active essential oils elemicin and myristicin found in nutmeg. MMDA is most typically taken orally (as pressed tablets) or intranasaly (as a powder).

MMDA was written up by Alexander Shulgin in his book, "PiHKAL." Shulgin lists the dosage range of MMDA as 100-250 mg. The first symptoms appear within 30-60 minutes following oral administration. MMDA causes accentuation of feelings such as anxiety, euphoria, loneliness, and loving warmth. MMDA also produces eyes-closed visuals, a state of drowsiness and muscular relaxation, and time distortion. Side effects include moderate mydriasis, dizziness, sensations of heat or cold, and trembling. The imagery is generally realistic, and often related to everyday perception of people, landscapes, or objects. The effects of MMDA usually reach a peak after the first hour following the initial symptoms, and begin to wane during the second hour, and usually completely disappear by the end of the fifth hour.

Analogs

MMDA-2

Dosage: 25-50 mgs

Duration: 8-12 hours

Effects: slow, MDA-like effects, muscle stiffness, inability to defecate

Methyl-MMDA-2

Dosage: unknown

Duration: unknown

Effects: Few to none

MMDA-3a

Dosage: 20-80 mgs

Duration: 10-16 hours

Effects: mild open-eye visuals, visual enhancement of music, slowing of time, slight diarrhea and body load

MMDA-3b

Dosage: unknown

Duration: unknown

Effects: Few to none

2T-MMDA-3a

Dosage: unknown

Duration: unknown

Effects: Few to none

4T-MMDA-2

Dosage: 25 mg

Duration: unknown

Effects: Slight tremors

Psychotherapuetic actions

In his 1973 book, "The Healing Journey," Claudio Naranjo explored the psychotherapeutic potential of MMDA. Like MDA, he found that MMDA facilitates communication and suggested it has potential applications in psychotherapy. Worldwide as of 2005, MMDA has not been approved for any human applications.

Pharmacology

The mechanism that produces the psychedelic activity of MMDA has not been definitively established. There are, as of the present time, no reported studies on the human pharmacokinetics or metabolism of MMDA. Based on its structural relationship with other similar drugs for which the pharmacology is known, it is likely that MMDA has multiple mechanisms of action, and probably acts both as a 5HT_2A agonist in a similar manner to hallucinogenic amphetamines such as DOM, and also as a serotonin releaser by reversing the direction of the serotonin reuptake transporter in a similar manner to MDMA.

Legality

MMDA is classified as a Schedule 1 substance in the United States, and is similarly controlled in other parts of the world. Internationally, MMDA is a Schedule I drug under the Convention on Psychotropic Substances[2].

See also

• MDA
• MDMA
• PiHKAL

External links

• PIHKAL entry for MMDA
• MMDA: A New Psychotomimetic Agent
• Animal Pharmacology and Human Psychopharmacology of MMDA
• A Pharmacological Comparison of MMDA and LSD In The Dog

Template:Entactogens Template:Hallucinogenic phenethylamines Template:PiHKAL