X-linked dominant: Difference between revisions
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==Overview== | ==Overview== | ||
'''X-linked dominant''' is mode of [[mendelian inheritance|inheritance]] in which a [[gene]] on the [[X chromosome]] is [[dominant]].<ref>[http://www.lpch.org/DiseaseHealthInfo/HealthLibrary/genetics/xdomin.html X-linked Dominant: Incontinentia pigmenti - Lucile Packard Children's Hospital]</ref> Females can be more frequently affected than males since they have two X chromosomes that could potentially carry the abnormal gene, whereas a male has only one. However, the Lyon hypothesis states that X-inactivation renders only one copy of the X chromosome active in each cell hence on average one would expect only one half of the cells to express the abnormal gene. The chance of passing on an X-linked dominant disorder differs between men and women. | '''X-linked dominant''' is mode of [[mendelian inheritance|inheritance]] in which a [[gene]] on the [[X chromosome]] is [[dominant]].<ref>[http://www.lpch.org/DiseaseHealthInfo/HealthLibrary/genetics/xdomin.html X-linked Dominant: Incontinentia pigmenti - Lucile Packard Children's Hospital]</ref> Females can be more frequently affected than males since they have two X chromosomes that could potentially carry the abnormal gene, whereas a male has only one. However, the Lyon hypothesis states that X-inactivation renders only one copy of the X chromosome active in each cell hence on average one would expect only one half of the cells to express the abnormal gene. The chance of passing on an X-linked dominant disorder differs between men and women. | ||
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{{X-linked disorders}} | {{X-linked disorders}} | ||
[[Category:Genetic disorders]] | [[Category:Genetic disorders]] | ||
Latest revision as of 17:32, 20 August 2012
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Overview
X-linked dominant is mode of inheritance in which a gene on the X chromosome is dominant.[1] Females can be more frequently affected than males since they have two X chromosomes that could potentially carry the abnormal gene, whereas a male has only one. However, the Lyon hypothesis states that X-inactivation renders only one copy of the X chromosome active in each cell hence on average one would expect only one half of the cells to express the abnormal gene. The chance of passing on an X-linked dominant disorder differs between men and women.
As a disease inheritance pattern, it is less common than X-linked recessive.
Inheritance
Females usually have two X chromosomes, while most males have one X and one Y chromosome. If a child has inherited the mutation from the X chromosome of one of their parents they will have the condition. A woman with an X-linked dominant disorder has a 50% chance of having an affected daughter or son with each pregnancy. The sons of a man with an X-linked dominant disorder will not be affected (since they inherit their only X chromosome from their mother), but his daughters will all inherit the condition.
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A woman with an X-linked dominant disorder has a 50% chance of having an affected child. -
The daughters of a man with an X-linked dominant disorder will all inherit the condition.
Some X-linked dominant conditions such as Aicardi Syndrome are fatal to boys, therefore only girls with these conditions survive. Similarly, individuals with Klinefelter's Syndrome are referred to as "47,XXY Males".