Sulbutiamine: Difference between revisions
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'''Sulbutiamine''' (brand name: '''Arcalion'''®) is a [[wiktionary:Precursor|precursor]] to [[thiamine]] (i.e., [[vitamin]] B<sub>1</sub>). It is indicated for the treatment of [[asthenia]].<ref name="Shah">{{cite journal | author=Shah SN; Sulbutiamine Study Group | title=Adjuvant role of vitamin B analogue (sulbutiamine) with anti-infective treatment in infection associated asthenia. | journal=J Assoc Physicians India | year=2003 | pages=891–5 | volume=51 | id=PMID 14710977}}</ref> Furthermore, the ability of sulbutiamine to reduce fatigue is considered desirable by athletes, and it is available for [[Over-the-counter drug|over-the-counter sale]] as a nutritional supplement. Additionally, the demonstrated ability of sulbutiamine to improve memory in rats<ref name="Bizot">{{cite journal | author=Bizot JC, Herpin A, Pothion S, Pirot S, Trovero F, Ollat H | title=Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task. | journal=Prog Neuropsychopharmacol Biol Psychiatry | year=2005 | pages=928–35 | volume=29 | issue=6 | id=PMID 15951087}}</ref> and patients of [[schizophrenia]]<ref name="Bizot">{{cite journal | author=Bizot JC, Herpin A, Pothion S, Pirot S, Trovero F, Ollat H | title=Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task. | journal=Prog Neuropsychopharmacol Biol Psychiatry | year=2005 | pages=928–35 | volume=29 | issue=6 | id=PMID 15951087}}</ref> suggests that it is a [[nootropics|nootropic]]. | '''Sulbutiamine''' (brand name: '''Arcalion'''®) is a [[wiktionary:Precursor|precursor]] to [[thiamine]] (i.e., [[vitamin]] B<sub>1</sub>). It is indicated for the treatment of [[asthenia]].<ref name="Shah">{{cite journal | author=Shah SN; Sulbutiamine Study Group | title=Adjuvant role of vitamin B analogue (sulbutiamine) with anti-infective treatment in infection associated asthenia. | journal=J Assoc Physicians India | year=2003 | pages=891–5 | volume=51 | id=PMID 14710977}}</ref> Furthermore, the ability of sulbutiamine to reduce fatigue is considered desirable by athletes, and it is available for [[Over-the-counter drug|over-the-counter sale]] as a nutritional supplement. Additionally, the demonstrated ability of sulbutiamine to improve memory in rats<ref name="Bizot">{{cite journal | author=Bizot JC, Herpin A, Pothion S, Pirot S, Trovero F, Ollat H | title=Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task. | journal=Prog Neuropsychopharmacol Biol Psychiatry | year=2005 | pages=928–35 | volume=29 | issue=6 | id=PMID 15951087}}</ref> and patients of [[schizophrenia]]<ref name="Bizot">{{cite journal | author=Bizot JC, Herpin A, Pothion S, Pirot S, Trovero F, Ollat H | title=Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task. | journal=Prog Neuropsychopharmacol Biol Psychiatry | year=2005 | pages=928–35 | volume=29 | issue=6 | id=PMID 15951087}}</ref> suggests that it is a [[nootropics|nootropic]]. | ||
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Latest revision as of 16:22, 20 August 2012
| Clinical data | |
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| Synonyms | Arcalion, bisibuthiamine, youvitan |
| Routes of administration | Oral |
| ATC code | |
| Pharmacokinetic data | |
| Elimination half-life | 5 hours |
| Excretion | Renal |
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| CAS Number | |
| PubChem CID | |
| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C32H46N8O6S2 |
| Molar mass | 702.89 g/mol |
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Overview
Sulbutiamine (brand name: Arcalion®) is a precursor to thiamine (i.e., vitamin B1). It is indicated for the treatment of asthenia.[1] Furthermore, the ability of sulbutiamine to reduce fatigue is considered desirable by athletes, and it is available for over-the-counter sale as a nutritional supplement. Additionally, the demonstrated ability of sulbutiamine to improve memory in rats[2] and patients of schizophrenia[2] suggests that it is a nootropic.
Effects
Sulbutiamine reduces fatigue, memory difficulties, intellectual tiredness and may speed convalescence.[3]
Dosage
Sulbutiamine is sometimes supplied in 200 mg tablets. The proper therapeutic dosage has been reported to be 12.5 mg/kg,[2] which corresponds to 850 mg for a 68 kg (150 lb) person. However, it should be noted that dosage recommendations vary; the manufacturer of Arcalion, for example, recommends no more than 600 mg per day.
References
- ↑ Shah SN; Sulbutiamine Study Group (2003). "Adjuvant role of vitamin B analogue (sulbutiamine) with anti-infective treatment in infection associated asthenia". J Assoc Physicians India. 51: 891&ndash, 5. PMID 14710977.
- ↑ 2.0 2.1 2.2 Bizot JC, Herpin A, Pothion S, Pirot S, Trovero F, Ollat H (2005). "Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task". Prog Neuropsychopharmacol Biol Psychiatry. 29 (6): 928&ndash, 35. PMID 15951087.
- ↑ http://www.serdiapharma.com/about/arcalion.asp
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