ADAMTS10: Difference between revisions
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'''ADAM metallopeptidase with thrombospondin type 1 motif, 10''', also known as '''ADAMTS10''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81794| accessdate = }}</ref> | '''ADAM metallopeptidase with thrombospondin type 1 motif, 10''', also known as '''ADAMTS10''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81794| accessdate = }}</ref> | ||
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Revision as of 19:13, 8 August 2012
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Overview
ADAM metallopeptidase with thrombospondin type 1 motif, 10, also known as ADAMTS10, is a human gene.[1]
This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome.[1]
References
Further reading
- Tang BL (2001). "ADAMTS: a novel family of extracellular matrix proteases". Int. J. Biochem. Cell Biol. 33 (1): 33–44. PMID 11167130.
- Faivre L, Dollfus H, Lyonnet S; et al. (2004). "Clinical homogeneity and genetic heterogeneity in Weill-Marchesani syndrome". Am. J. Med. Genet. A. 123 (2): 204–7. doi:10.1002/ajmg.a.20289. PMID 14598350.
- Apte SS (2004). "A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motifs: the ADAMTS family". Int. J. Biochem. Cell Biol. 36 (6): 981–5. doi:10.1016/j.biocel.2004.01.014. PMID 15094112.
- Faivre L, Mégarbané A, Alswaid A; et al. (2002). "Homozygosity mapping of a Weill-Marchesani syndrome locus to chromosome 19p13.3-p13.2". Hum. Genet. 110 (4): 366–70. doi:10.1007/s00439-002-0689-3. PMID 11941487.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
- Fu GK, Wang JT, Yang J; et al. (2005). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes". Genomics. 84 (1): 205–10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
- Somerville RP, Jungers KA, Apte SS (2005). "Discovery and characterization of a novel, widely expressed metalloprotease, ADAMTS10, and its proteolytic activation". J. Biol. Chem. 279 (49): 51208–17. doi:10.1074/jbc.M409036200. PMID 15355968.
- Charrier L, Yan Y, Driss A; et al. (2005). "ADAM-15 inhibits wound healing in human intestinal epithelial cell monolayers". Am. J. Physiol. Gastrointest. Liver Physiol. 288 (2): G346–53. doi:10.1152/ajpgi.00262.2004. PMID 15358598.
- Dagoneau N, Benoist-Lasselin C, Huber C; et al. (2005). "ADAMTS10 mutations in autosomal recessive Weill-Marchesani syndrome". Am. J. Hum. Genet. 75 (5): 801–6. doi:10.1086/425231. PMID 15368195.